Irosha N. Nawarathne
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Professor and Director of Undergraduate Research
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Irosha N. Nawarathne's research focuses on the biocatalytic modification of taxoids to create precursors for next-generation paclitaxel drugs. This work involves regioselective exchange of benzoyl groups, contributing to the development of new cancer therapeutics. Nawarathne has also investigated the analysis of rice bran oil to compare fatty acid compositions in different rice lines and explored methods for generating single-stranded DNA circles. Their publications cover diverse areas including organic chemistry, analytical chemistry, and molecular biology techniques. Nawarathne holds an h-index of 6 with 123 citations across 11 publications. They have collaborated with researchers from institutions including the University of Arkansas for Medical Sciences and Arkansas State University.
Metrics
- h-index: 6
- Publications: 11
- Citations: 123
Selected Publications
-
Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives (2026)
-
Cover Feature: Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024) (2024)
-
Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (2024)
-
Correction to “Alkenes, Brought to You in Familiar Faces” (2022)
-
Alkenes, Brought to You in Familiar Faces (2022)
-
Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines (2022)
-
Generating single-stranded DNA circles with minimal resources (2021)
-
CoA recycling by a benzoate coenzyme A ligase in cascade reactions with aroyltransferases to biocatalyze paclitaxel analogs (2020)
-
Introducing Diversity through an Organic Approach (2019)
-
X-ray Crystal Structures of the <i>Escherichia coli</i> RNA Polymerase in Complex with Benzoxazinorifamycins (2013)
-
Point Mutations (Q19P and N23K) Increase the Operational Solubility of a 2α-<i>O</i>-Benzoyltransferase that Conveys Various Acyl Groups from CoA to a Taxane Acceptor (2010)
-
An <i>N</i>-Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificity <i>in Vitro</i> with Analogues of <i>N</i>-Dearoylpaclitaxel (2009)
Collaboration Network
Top Collaborators
- Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
- Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
- Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
- Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐<i>O</i>‐Benzoyl for 2‐<i>O</i>‐(<i>m</i>‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
- Generating single-stranded DNA circles with minimal resources
- Generating single-stranded DNA circles with minimal resources
- Generating single-stranded DNA circles with minimal resources
- Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines
- Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines
- Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines
- Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines
- Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives
- Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives
- Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives
- Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives
Similar Researchers
Based on overlapping research topics