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Presence
Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-08
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Narasimhan Rajaram
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
Also affiliated: Dartmouth College (2025); Duke University (2011–2018); University of Arkansas Medical Center (2023); University of Arkansas System (2023); The University of Texas at Austin (2007–2014)
25 h-index
126 pubs
1,942 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Narasimhan Rajaram's research focuses on the development and application of optical spectroscopy techniques for medical diagnostics, particularly in the field of skin cancer detection. He has investigated methods for determining the optical properties of biological tissues and has explored the use of spectral diagnosis for non-invasive in vivo assessment of melanoma and non-melanoma skin cancers.
His work includes studies on the impact of probe pressure on diffuse reflectance and fluorescence spectroscopy measurements of human skin. Rajaram has also examined the optical redox ratio as an indicator of metabolic changes in breast cancer cells, suggesting its potential for identifying metastatic potential. Furthermore, his research has explored the in vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy and the application of label-free Raman spectroscopy to identify signatures of radiation resistance in the tumor microenvironment.
Rajaram has received significant federal funding for his work, including substantial grants from the NIH for establishing integrative metabolic research centers and developing multidisciplinary research spaces. He has also been funded by the NSF for developing multimodal imaging platforms. With 126 publications and an h-index of 25, his scholarship metrics indicate a sustained contribution to his field. Key collaborators include Joel Rodríguez Troncoso, Paola Monterroso Díaz, and Jesse D. Ivers from the University of Arkansas at Fayetteville, and Ruud P.M. Dings from the University of Arkansas for Medical Sciences.
Metrics
- h-index: 25
- Publications: 126
- Citations: 1,942
Positions
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Professor 2025–presentUniversity of Arkansas at Fayetteville Biomedical Engineering ORCID
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Associate Professor 2020–2025University of Arkansas Biomedical Engineering ORCID
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Assistant Professor 2014–2020University of Arkansas Fayetteville Biomedical Engineering ORCID
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Research Scientist 2013–2014Duke University Biomedical Engineering ORCID
Selected Publications
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Abstract 7625: Development of a blood-based tumor hypoxia detection assay (2026)
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Optical metabolic imaging of tumor recurrence in non-small cell lung cancer (2026)
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Metabolic Imaging and Characterization of Multicomponent Spheroid Models in Vitro. (2025)
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Advancing Optical Techniques for Cancer Diagnosis and Therapy Monitoring (2025)
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Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling (2025)
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Investigating Biomarkers of Radiation Resistance in Head and Neck Cancer Using Raman Spectroscopy (2025)
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Investigating Tissue Changes Due to Alcohol and Tobacco Consumption Using Optical Spectroscopy (2025)
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Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications (2024)
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Erratum: Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
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Optical imaging of treatment-naïve human NSCLC reveals changes associated with metastatic recurrence (2024)
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Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy (2024)
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Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections (2024)
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Rapid Optical Sensing of Infection in Joint Fluids (2024)
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Design and Validation of a Multimodal Spatially Offset System Comprising Diffuse Reflectance Spectroscopy and Raman Spectroscopy (2024)
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Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
Federal Grants 4 $10,550,322 total
NIH
Contact PI
Sep 2026 - May 2031
NIH
Contact PI
Apr 2021 - Feb 2031
NIH
Contact PI
Aug 2019 - Jul 2026
NSF
PI
Sep 2021 - Feb 2023
I-Corps: Multimodal imaging platform to image bioenergetics in live tissue
Collaboration Network
Top Collaborators
Joel Rodríguez Troncoso
University of Arkansas at Fayetteville
18 shared publications
In database
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Optical spectroscopic sensing of tumor hypoxia
- Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors
- Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation
- Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer
Showing 5 of 18 shared publications
Paola Monterroso Díaz
University of Arkansas at Fayetteville
14 shared publications
In database
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Pulsed terahertz reflection imaging of tumors in a spontaneous model of breast cancer
- Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Quantitative Diffuse Optical Spectroscopy of Short-term Reoxygenation Kinetics in Radiation-Resistant and Sensitive Tumors
Showing 5 of 14 shared publications
Sina Dadgar
University of Arkansas at Little Rock (US)
14 shared publications
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens
- Optical spectroscopic sensing of tumor hypoxia
- Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors
- Optical Imaging Approaches to Investigating Radiation Resistance
Showing 5 of 14 shared publications
Ruud P.M. Dings
University of Arkansas at Fayetteville
13 shared publications
In database
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells
- A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro
- Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance
- Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors
Showing 5 of 13 shared publications
David E. Lee
University of Arkansas at Fayetteville (US)
13 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells
- A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro
- Cancer‐induced cardiac atrophy adversely affects myocardial redox state and mitochondrial oxidative characteristics
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
Showing 5 of 13 shared publications
Timothy J. Muldoon
University of Arkansas at Fayetteville
12 shared publications
In database
- Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
- Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe
Showing 5 of 12 shared publications
Kinan Alhallak
University of Arkansas at Fayetteville (US)
11 shared publications
- Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism
- Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells
- A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro
- Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance
- Rapid quantification of mitochondrial fractal dimension in individual cells
Showing 5 of 11 shared publications
Kyle P. Quinn
University of Arkansas at Fayetteville
11 shared publications
In database
- Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells
- A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro
- Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling
Showing 5 of 11 shared publications
Santosh Kumar Paidi
Johns Hopkins University (US)
11 shared publications
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Multimodal Optical Spectroscopy of Functional and Molecular Changes in Tumors after Radiation Therapy
Showing 5 of 11 shared publications
Ishan Barman
Johns Hopkins University (US)
11 shared publications
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Multimodal Optical Spectroscopy of Functional and Molecular Changes in Tumors after Radiation Therapy
Showing 5 of 11 shared publications
Jesse D. Ivers
University of Arkansas at Fayetteville
11 shared publications
In database
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
Showing 5 of 11 shared publications
Gage J. Greening
University of Arkansas at Fayetteville (US)
9 shared publications
- Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
- Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe
- Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy
- Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response (Erratum)
Showing 5 of 9 shared publications
Charles M. Quick
University of Arkansas for Medical Sciences
9 shared publications
In database
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
Showing 5 of 9 shared publications
Lisa Rebello
University of Arkansas at Fayetteville
8 shared publications
In database
- Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Optical Imaging of Cancer Cell Metabolism in Murine Metastatic Breast Cancer
- Optical Metabolic Imaging of TWIST Inhibition in 4T1 Breast Cancer Cells
Showing 5 of 8 shared publications
Robert J. Griffin
8 shared publications
In database
- Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells
- A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro
- Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance
- Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors
Showing 5 of 8 shared publications
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