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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-08
T
Timothy J. Muldoon
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
Associate Professor
Also affiliated: University of North Carolina at Chapel Hill (2024); North Carolina State University (2024); University of Utah (2024); Rice University (2007–2012); Columbia University (2012); University of California, Davis (2024); University of Toledo (2024)
17 h-index
96 pubs
1,406 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Timothy J. Muldoon's research focuses on the development and application of advanced optical imaging techniques for biomedical applications. His work has explored the use of fiber microendoscopy for subcellular-resolution molecular imaging within living tissue and for high-resolution imaging of conditions such as Barrett's esophagus and oral neoplasia. He has also investigated the synergistic effects of photothermal therapy and antibiotics using targeted nanoconstructs for combating biofilm-associated bacterial infections, specifically Staphylococcus aureus.
Muldoon's research also extends to the creation of tissue-simulating phantoms with tunable optical properties, which are crucial for calibrating and validating imaging systems. He has explored metabolic changes in cancer cells, identifying optical redox ratios that correlate with metastatic potential in breast cancer. His methodological work includes the application of generalized additive models for analyzing nonlinear trends in longitudinal biomedical data.
He has received a National Science Foundation Research Experiences for Undergraduates (REU) grant for $414,426 to support training in emerging biomedical optics and imaging approaches. Muldoon has a h-index of 17 and has authored 96 publications with over 1,300 citations. He actively collaborates with researchers at the University of Arkansas at Fayetteville, including Shelby N. Bess, Mostafa Elsaadany, Matthew J. Igoe, and Christopher E. Nelson.
Metrics
- h-index: 17
- Publications: 96
- Citations: 1,406
Positions
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Associate Professor 2018–presentUniversity of Arkansas Department of Biomedical Engineering ORCID
Selected Publications
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Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a preclinical model of colorectal cancer by biological sex (2026)
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Metabolic Imaging and Characterization of Multicomponent Spheroid Models in Vitro. (2025)
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BOARD # 307: University of Arkansas Biomedical Engineering REU Site: Training in Emerging Biomedical Optics and Imaging Approaches (2025)
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BOARD # 16: Equipping Biomedical Engineering Students with User-Centered Design Skills: Insights from a Clinical Immersion Course (2025)
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Advancing Equity in Biomedical Engineering Education: Insights from Clinical Observations and Needs-Finding Courses (2025)
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A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct (2025)
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Quantifying treatment response to a macrophage-targeted therapy in combination with immune checkpoint inhibitors after exposure to conventional chemotherapy (2025)
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The Physiological and Therapeutic Role of CD47 in Macrophage Function and Cancer (2024)
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Development of an Innovation Corps-Modelled Bioengineering Course to Promote Entrepreneurial Engagement Among Undergraduate Students (2024)
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Toward Equity and Inclusivity in Engineering Classrooms: Understanding Students' Disparities in Response to Clinical Observations and Needs-Finding Course Development (2024)
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Assessment and Impact of a Clinical Observations and Needs Finding Course on Biomedical Engineering Education Outcomes (2024)
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Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles (2024)
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Abstract 5549: Multicellular spheroid structural and metabolic characterization through radial line profiling (2024)
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Board 107: Work in Progress: Development of an Innovation Corps-Modeled Bioengineering Course to Promote Entrepreneurial Engagement among Undergraduate Students. (2024)
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Board 12: Work in progress: Assessment and impact of a Clinical Observations and Needs Finding service-learning course on Biomedical Engineering outcomes (2024)
Federal Grants 1 $414,426 total
NSF
PI
May 2023 - Apr 2027
REU Site: Training in Emerging Biomedical Optics and Imaging Approaches
Collaboration Network
Top Collaborators
Gage J. Greening
University of Arkansas at Fayetteville (US)
23 shared publications
- Characterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients at visible and near-infrared wavelengths
- Two-layer inverse model for improved longitudinal preclinical tumor imaging in the spatial frequency domain
- Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
- Effects of isoflurane anesthesia on physiological parameters in murine subcutaneous tumor allografts measured via diffuse reflectance spectroscopy
Showing 5 of 23 shared publications
Amy J. Powless
University of Arkansas at Fayetteville
16 shared publications
In database
- Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Staphylococcus aureus Using Targeted Antibiotic-Loaded Gold Nanoconstructs
- Considerations for point-of-care diagnostics: evaluation of acridine orange staining and postprocessing methods for a three-part leukocyte differential test
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
- Redox-Magnetohydrodynamically Controlled Fluid Flow with Poly(3,4-ethylenedioxythiophene) Coupled to an Epitaxial Light Sheet Confocal Microscope for Image Cytometry Applications
- Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology
Showing 5 of 16 shared publications
Shelby N. Bess
University of Arkansas at Fayetteville
14 shared publications
In database
- Efficacy and clinical monitoring strategies for immune checkpoint inhibitors and targeted cytokine immunotherapy for locally advanced and metastatic colorectal cancer
- Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles
- Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages
- Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy
- The Physiological and Therapeutic Role of CD47 in Macrophage Function and Cancer
Showing 5 of 14 shared publications
Sandra P. Prieto
University of Arkansas at Fayetteville
13 shared publications
In database
- Quantitative analysis ofex vivocolorectal epithelium using an automated feature extraction algorithm for microendoscopy image data
- Fluorescein as a topical fluorescent contrast agent for quantitative microendoscopic inspection of colorectal epithelium
- Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development
- Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology
- Qualitative and quantitative comparison of colonic microendoscopy image features to histopathology
Showing 5 of 13 shared publications
Ariel I. Mundo
University of Arkansas at Fayetteville (US)
13 shared publications
- Generalized additive models to analyze nonlinear trends in biomedical longitudinal data using R: Beyond repeated measures ANOVA and linear mixed models
- Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts
- Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response (Erratum)
- Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
Showing 5 of 13 shared publications
Narasimhan Rajaram
University of Arkansas at Fayetteville
11 shared publications
In database
- Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
- Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe
Showing 5 of 11 shared publications
Joshua A. Hutcheson
University of Arkansas at Fayetteville (US)
9 shared publications
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
- Redox-Magnetohydrodynamically Controlled Fluid Flow with Poly(3,4-ethylenedioxythiophene) Coupled to an Epitaxial Light Sheet Confocal Microscope for Image Cytometry Applications
- Design and validation of a diffuse reflectance and spectroscopic microendoscope with poly(dimethylsiloxane)-based phantoms
- A widefield fluorescence microscope with a linear image sensor for image cytometry of biospecimens: Considerations for image quality optimization
- A light sheet confocal microscope for image cytometry with a variable linear slit detector
Showing 5 of 9 shared publications
Mostafa Elsaadany
University of Arkansas at Fayetteville
9 shared publications
In database
- Employing Faculty, Peer Mentoring and Coaching to Increase the Self-Confidence and Belongingness of First-Generation College Students in Biomedical Engineering
- Instructional and learning opportunities for remote offerings of integrated lab-lecture core undergraduate biomedical engineering courses
- Board 12: Work in progress: Assessment and impact of a Clinical Observations and Needs Finding service-learning course on Biomedical Engineering outcomes
- Board 107: Work in Progress: Development of an Innovation Corps-Modeled Bioengineering Course to Promote Entrepreneurial Engagement among Undergraduate Students.
- Assessment and Impact of a Clinical Observations and Needs Finding Course on Biomedical Engineering Education Outcomes
Showing 5 of 9 shared publications
Kartik Balachandran
University of Arkansas at Fayetteville
6 shared publications
In database
- Characterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients at visible and near-infrared wavelengths
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model
- High-throughput microfluidic line scan imaging for cytological characterization
- A Fluorescence Imaging Optofluidics Device for Cytologic Morphology Assessment
Showing 5 of 6 shared publications
Ingrid Fritsch
University of Arkansas at Fayetteville
6 shared publications
In database
- Redox-Magnetohydrodynamically Controlled Fluid Flow with Poly(3,4-ethylenedioxythiophene) Coupled to an Epitaxial Light Sheet Confocal Microscope for Image Cytometry Applications
- A light sheet confocal microscope for image cytometry with a variable linear slit detector
- High-throughput microfluidic line scan imaging for cytological characterization
- New Advances and Opportunities of Magnetohydrodynamic Microfluidics
- Microfluidics with Alternating Current-Redox Magnetohydrodynamics at Modified Electrodes for Cell Identification
Showing 5 of 6 shared publications
Kyle P. Quinn
University of Arkansas at Fayetteville
6 shared publications
In database
- Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development
- Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model
- Optical spectroscopic and imaging biomarkers of ulcerative colitis disease progression and remission (Conference Presentation)
Showing 5 of 6 shared publications
Aneeka A. Majid
University of Arkansas at Fayetteville (US)
5 shared publications
- Design and validation of a diffuse reflectance and spectroscopic microendoscope with poly(dimethylsiloxane)-based phantoms
- A widefield fluorescence microscope with a linear image sensor for image cytometry of biospecimens: Considerations for image quality optimization
- High-throughput microfluidic line scan imaging for cytological characterization
- Fiber Bundle Microendoscopy for Characterization of Dysplastic Lesions in Colonic Epithelium
- A Fluorescence Imaging Optofluidics Device for Cytologic Morphology Assessment
Haley M. James
University of Arkansas at Fayetteville
5 shared publications
In database
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
- Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe
- Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development
- Optical metabolic imaging of colorectal adenocarcinoma derived organoids: assessing cellular-level resistance to therapy (Conference Presentation)
- Monitoring therapeutic response of murine tumor allografts of colon carcinoma in response to combined immunotherapy and chemotherapy (Conference Presentation)
Foysal Z. Khan
University of Arkansas at Fayetteville
5 shared publications
In database
- Redox-Magnetohydrodynamically Controlled Fluid Flow with Poly(3,4-ethylenedioxythiophene) Coupled to an Epitaxial Light Sheet Confocal Microscope for Image Cytometry Applications
- A light sheet confocal microscope for image cytometry with a variable linear slit detector
- New Advances and Opportunities of Magnetohydrodynamic Microfluidics
- Microfluidics with Alternating Current-Redox Magnetohydrodynamics at Modified Electrodes for Cell Identification
- Manipulating Microvolumes of Fluids By Redox-Magnetohydrodynamics for Applications in Chemical Analysis
Matthew J. Igoe
University of Arkansas at Fayetteville
5 shared publications
In database
- Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles
- Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages
- The Physiological and Therapeutic Role of CD47 in Macrophage Function and Cancer
- Live-Cell Imaging Quantifies Changes in Function and Metabolic NADH Autofluorescence During Macrophage-Mediated Phagocytosis of Tumor Cells
- Abstract 5549: Multicellular spheroid structural and metabolic characterization through radial line profiling
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