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Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
T
Thallapuranam Krishnaswamy Suresh Kumar
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
Also affiliated: Novartis (Switzerland) (1998); University of Miami (2007); National Taiwan Ocean University (2005); University of Leicester (1998); Centre for Cellular and Molecular Biology (1992–1995); Florida International University (2007); National Tsing Hua University (1995–2007); Biotechnology Research Institute (2005); Maine Medical Center Research Institute (2005–2007); National Research Council Canada (2005); The Ohio State University (2001–2005); Osmania University (1988–1990)
30 h-index
200 pubs
3,227 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Thallapuranam Krishnaswamy Suresh Kumar's research focuses on understanding protein structure, dynamics, and folding mechanisms, particularly in response to environmental stressors and therapeutic agents. He has investigated the effects of agents like trichloroacetic acid on protein precipitation, identifying reversible associations with partially structured intermediates. His work also extends to controlling encapsulation methods for delivering proteins and vaccines using chitosan-based systems. Additionally, Kumar has explored the regulation of cancer cell apoptosis in response to anticancer agents through oxidative phosphorylation pathways.
Kumar is a principal investigator on a grant from the NIH/National Institute of General Medical Sciences for $435,226, which supports research into hyperstable FGF1-FGF2 based therapeutic formulations for wound care. He has published extensively, with a total of 241 publications and 3,615 citations, and holds an h-index of 32, designating him as a highly cited researcher. He leads an active research group at the University of Arkansas at Fayetteville and collaborates with several colleagues, including Shilpi Agrawal, Vivek Govind Kumar, Zeina Alraawi, and Mahmoud Moradi.
Metrics
- h-index: 30
- Publications: 200
- Citations: 3,227
Positions
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Professor publications 2003–2026University of Arkansas Fayetteville Chemistry and Biochemistry ORCID
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Associate Professor publications 2003–2026University of Arkansas Fayetteville Chemistry and Biochemistry ORCID
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Assistant Professor publications 2003–2026University of Arkansas Fayetteville Chemistry and Biochemistry ORCID
Selected Publications
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Corrigendum to “One-step purification of a bioactive PAK1-derived peptide” [Anal. Biochem. (2026), 709, 116014] (2026)
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Harnessing Affinity Tags for Recombinant Protein Purification: Concepts, Methods, and Troubleshooting (2026)
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One-step purification of a bioactive PAK1-derived peptide (2025)
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Signaling of Mitogenic and Metabolic Activities by Fibroblast Growth Factors (2025)
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Pathology and Therapeutic Significance of Fibroblast Growth Factors (2025)
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Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance (2024)
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Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant? (2024)
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Overexpression and Purification of Mitogenic and Metabolic Fibroblast Growth Factors (2024)
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A Review of Rattlesnake Venoms (2023)
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Foreword I (2023)
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cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach (2023)
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A Simple Purification Method for Heat-Stable Recombinant Low Molecular Weight Proteins and Peptides Via GST-Fusion Products (2023)
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Binding affinity estimation from restrained umbrella sampling simulations (2022)
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Amyloidogenesis: What Do We Know So Far? (2022)
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Binding Affinity Estimation from Restrained Umbrella Sampling Simulations (2022)
Federal Grants 1 $435,226 total
NIH
Contact PI
Sep 2024 - Aug 2027
Hyperstable FGF1-FGF2 based therapeutic formulation for wound care
Collaboration Network
Top Collaborators
Srinivas Jayanthi
University of Arkansas at Fayetteville
33 shared publications
In database
- Controlling chitosan-based encapsulation for protein and vaccine delivery
- Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents
- Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer
- Modulation of Interleukin-12 activity in the presence of heparin
- Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity
Showing 5 of 33 shared publications
Dakshinamurthy Rajalingam
University of Arkansas at Fayetteville (US)
22 shared publications
- Trichloroacetic acid‐induced protein precipitation involves the reversible association of a stable partially structured intermediate
- Secretion without Golgi
- Copper Binding Affinity of S100A13, a Key Component of the FGF-1 Nonclassical Copper-Dependent Release Complex
- A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components*
- The C2A Domain of Synaptotagmin Exhibits a High Binding Affinity for Copper: Implications in the Formation of the Multiprotein FGF Release Complex
Showing 5 of 22 shared publications
Karuppanan Muthusamy Kathir
University of Arkansas at Fayetteville (US)
17 shared publications
- Secretion without Golgi
- A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components*
- Carbon nanotubes prevent 2,2,2 trifluoroethanol induced aggregation of protein
- Understanding the Mechanism of the Antimitogenic Activity of Suramin
- Assembly of Chloroplast Signal Recognition Particle Involves Structural Rearrangement in cpSRP43
Showing 5 of 17 shared publications
Shilpi Agrawal
University of Arkansas at Fayetteville
16 shared publications
In database
- Binding affinity estimation from restrained umbrella sampling simulations
- The Saga of Endocrine FGFs
- Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling
- DNA aptamer-based rolling circle amplification product as a novel immunological adjuvant
- Design of a thrombin resistant human acidic fibroblast growth factor (hFGF1) variant that exhibits enhanced cell proliferation activity
Showing 5 of 16 shared publications
Ralph Henry
University of Arkansas at Fayetteville (US)
15 shared publications
- A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components*
- The Membrane-binding Motif of the Chloroplast Signal Recognition Particle Receptor (cpFtsY) Regulates GTPase Activity
- Three-Dimensional Solution Structures of the Chromodomains of cpSRP43
- Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates
- Heparin-binding peptide as a novel affinity tag for purification of recombinant proteins
Showing 5 of 15 shared publications
Chin Yu
National Tsing Hua University (TW)
14 shared publications
- Copper Binding Affinity of S100A13, a Key Component of the FGF-1 Nonclassical Copper-Dependent Release Complex
- Carbon nanotubes prevent 2,2,2 trifluoroethanol induced aggregation of protein
- The C2A Domain of Synaptotagmin Exhibits a High Binding Affinity for Copper: Implications in the Formation of the Multiprotein FGF Release Complex
- Understanding the Mechanism of the Antimitogenic Activity of Suramin
- Three-Dimensional Solution Structures of the Chromodomains of cpSRP43
Showing 5 of 14 shared publications
Igor Prudovsky
Maine Medical Center Research Institute (US)
13 shared publications
- Secretion without Golgi
- Copper Binding Affinity of S100A13, a Key Component of the FGF-1 Nonclassical Copper-Dependent Release Complex
- Release of FGF1 and p40 synaptotagmin 1 correlates with their membrane destabilizing ability
- Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study
- Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1
Showing 5 of 13 shared publications
Robyn L. Goforth
University of Arkansas at Fayetteville (US)
13 shared publications
- A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components*
- The Membrane-binding Motif of the Chloroplast Signal Recognition Particle Receptor (cpFtsY) Regulates GTPase Activity
- Three-Dimensional Solution Structures of the Chromodomains of cpSRP43
- Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates
- Assembly of Chloroplast Signal Recognition Particle Involves Structural Rearrangement in cpSRP43
Showing 5 of 13 shared publications
Anna E. Daily
University of Arkansas at Fayetteville (US)
11 shared publications
- A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components*
- Heparin-binding peptide as a novel affinity tag for purification of recombinant proteins
- NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I—relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1)
- Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor
- Defining the Interaction Between S100A13 and Annexin II Peptide: Insight into Non-Classical Secretion
Showing 5 of 11 shared publications
Ravi Kumar Gundampati
University of Arkansas at Fayetteville
11 shared publications
In database
- NMR Methods to Characterize Protein-Ligand Interactions
- Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer
- Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity
- Design of a thrombin resistant human acidic fibroblast growth factor (hFGF1) variant that exhibits enhanced cell proliferation activity
- Biocompatible, Injectable Anionic Hydrogels Based on Poly(Oligo Ethylene Glycol Monoacrylate‐co‐Acrylic Acid) for Protein Delivery
Showing 5 of 11 shared publications
Alicia Kight
University of Arkansas at Fayetteville
10 shared publications
In database
- A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components*
- The Membrane-binding Motif of the Chloroplast Signal Recognition Particle Receptor (cpFtsY) Regulates GTPase Activity
- Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates
- Heparin-binding peptide as a novel affinity tag for purification of recombinant proteins
- Assembly of Chloroplast Signal Recognition Particle Involves Structural Rearrangement in cpSRP43
Showing 5 of 10 shared publications
Mahmoud Moradi
University of Arkansas at Fayetteville
10 shared publications
In database
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
Showing 5 of 10 shared publications
Colin D. Heyes
University of Arkansas at Fayetteville
9 shared publications
In database
- Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates
- Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor
- Domain Organization in the 54-kDa Subunit of the Chloroplast Signal Recognition Particle
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach
Showing 5 of 9 shared publications
Vivek Govind Kumar
University of Arkansas at Fayetteville
9 shared publications
In database
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
Showing 5 of 9 shared publications
Zeina Alraawi
University of Arkansas at Fayetteville
9 shared publications
In database
- The Saga of Endocrine FGFs
- Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
- Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling
- Amyloidogenesis: What Do We Know So Far?
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
Showing 5 of 9 shared publications
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