Thallapuranam Krishnaswamy Suresh Kumar Source Confirmed
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Assistant Professor
University of Arkansas at Fayetteville
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Biography and Research Information
OverviewAI-generated summary
Thallapuranam Krishnaswamy Suresh Kumar's research focuses on understanding the biological functions and therapeutic potential of fibroblast growth factors (FGFs), particularly FGF1 and FGF2. His work investigates the structural forces and stabilization mechanisms that govern protein behavior, such as the reversibility of thermal unfolding in human acidic fibroblast growth factor. He also explores the role of heparin binding in stabilizing monomeric human fibroblast growth factor 1.
Beyond protein structure, Kumar's research extends to therapeutic applications. He is the Principal Investigator on an NIH/National Institute of General Medical Sciences grant totaling $435,226 for the development of hyperstable FGF1-FGF2 based therapeutic formulations for wound care. His publications also address the potential of nanostructured lipid carriers as drug delivery systems and the influence of the microenvironment on cancer states, specifically small-cell lung cancer, highlighting therapeutic opportunities.
Kumar's broader interests include the roles of gut bacteria and diet in health, as well as decoding signaling pathways like FGF/FGFR in disease relevance. His scholarship metrics include an h-index of 34, with 277 total publications and 4,168 total citations. He collaborates with researchers at the University of Arkansas at Fayetteville and the University of Arkansas at Little Rock.
Metrics
- h-index: 34
- Publications: 277
- Citations: 4,168
Selected Publications
- One-step purification of a bioactive PAK1-derived peptide (2025) DOI
- Pathology and Therapeutic Significance of Fibroblast Growth Factors (2025) DOI
- Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance (2024) DOI
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant? (2024) DOI
- Foreword I (2023) DOI
- cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach (2023) DOI
- A Simple Purification Method for Heat-Stable Recombinant Low Molecular Weight Proteins and Peptides Via GST-Fusion Products (2023) DOI
- Binding affinity estimation from restrained umbrella sampling simulations (2022) DOI
- Binding Affinity Estimation from Restrained Umbrella Sampling Simulations (2022) DOI
- Design and characterization of a FGF1‐FGF21 chimeric protein with increased stability and enhanced antidiabetic activities (2022) DOI
- Characterization of the Structure, Stability, Bioactivity of Recombinant FGF19 (2022) DOI
- cpSRP43 is both highly flexible and stable: Structural insights using a combined experimental and computational approach (2022) DOI
- Site-specific labeling and functional efficiencies of human fibroblast growth Factor-1 with a range of fluorescent Dyes in the flexible N-Terminal region and a rigid β-turn region (2021) DOI
- Binding Affinity Estimation From Restrained Umbrella Sampling Simulations (2021) DOI
- Antioxidant activities of solid‐state fermentation derived proteins and peptides from heat‐stabilized defatted rice bran (2021) DOI
Federal Grants 1 $435,226 total
Hyperstable FGF1-FGF2 based therapeutic formulation for wound care
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