Shilpi Agrawal Data-verified
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Postdoctoral Research Scientist III
postdoc
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Biography and Research Information
OverviewAI-generated summary
Shilpi Agrawal's research focuses on understanding the molecular mechanisms underlying protein behavior and interactions, particularly concerning fibroblast growth factors (FGFs) and their binding partners. Her work has investigated the structural forces that govern protein stability and unfolding, employing techniques such as molecular dynamics simulations to estimate binding affinities. Agrawal has also explored the stabilization of monomeric human fibroblast growth factor 1 by heparin binding. More recently, her research has extended into the application of CRISPR-Cas9 technology, with publications addressing delivery challenges for Duchenne muscular dystrophy and the advancement of CRISPR-based solutions for COVID-19 diagnosis and therapeutics. She has also focused on optimizing recombinant Cas9 expression for enhanced protein purification and genome editing applications. Agrawal has a notable record of collaboration with researchers at the University of Arkansas at Fayetteville, including Christopher E. Nelson, Thallapuranam Krishnaswamy Suresh Kumar, Made Harumi Padmaswari, and Mahmoud Moradi, with whom she shares multiple publications. Her scholarship metrics include an h-index of 11, 55 total publications, and 479 total citations.
Metrics
- h-index: 11
- Publications: 59
- Citations: 541
Selected Publications
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Beyond the Cut: Long-read sequencing reveals complex genomic and transcriptomic changes in AAV-CRISPR therapy for Duchenne Muscular Dystrophy (2025)
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Standardizing a Protocol for Streamlined Synthesis and Characterization of Lipid Nanoparticles to Enable Preclinical Research and Education (2025)
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A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct (2025)
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Unraveling Attention-Deficit/Hyperactivity Disorder Etiology: Current Challenges and Future Directions in Treatment (2025)
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Preclinical development of genome editing to treat Duchenne muscular dystrophy by exon skipping (2025)
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Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant? (2024)
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Advancing CRISPR-Based Solutions for COVID-19 Diagnosis and Therapeutics (2024)
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Resistance to Acetyl Coenzyme A Carboxylase (ACCase) Inhibitor in Lolium multiflorum: Effect of Multiple Target-Site Mutations (2024)
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Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci (2024)
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Optimizing Recombinant Cas9 Expression: Insights from E. coli BL21(DE3) Strains for Enhanced Protein Purification and Genome Editing (2024)
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Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci (2024)
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CRISPR-Cas9 Unleashed: Gene-Slicing Adventures in the Cancer Battlefield (2024)
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Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy (2023)
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Overexpression and cell-penetrating peptide-mediated delivery of Cas9 and its variant(s) for targeted genome editing (2023)
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Binding affinity estimation from restrained umbrella sampling simulations (2022)
Collaboration Network
Top Collaborators
- Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy
- Optimizing Recombinant Cas9 Expression: Insights from E. coli BL21(DE3) Strains for Enhanced Protein Purification and Genome Editing
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Preclinical development of genome editing to treat Duchenne muscular dystrophy by exon skipping
Showing 5 of 10 shared publications
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Binding Affinity Estimation from Restrained Umbrella Sampling Simulations
- Binding Affinity Estimation From Restrained Umbrella Sampling Simulations
Showing 5 of 8 shared publications
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Binding Affinity Estimation from Restrained Umbrella Sampling Simulations
- Binding Affinity Estimation From Restrained Umbrella Sampling Simulations
Showing 5 of 6 shared publications
- Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy
- Optimizing Recombinant Cas9 Expression: Insights from E. coli BL21(DE3) Strains for Enhanced Protein Purification and Genome Editing
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Preclinical development of genome editing to treat Duchenne muscular dystrophy by exon skipping
Showing 5 of 6 shared publications
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Binding Affinity Estimation from Restrained Umbrella Sampling Simulations
- Binding Affinity Estimation From Restrained Umbrella Sampling Simulations
- The Saga of Endocrine FGFs
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
- The Saga of Endocrine FGFs
- Advancing CRISPR-Based Solutions for COVID-19 Diagnosis and Therapeutics
- CRISPR-Cas9 Unleashed: Gene-Slicing Adventures in the Cancer Battlefield
- Unraveling Attention-Deficit/Hyperactivity Disorder Etiology: Current Challenges and Future Directions in Treatment
- Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Beyond the Cut: Long-read sequencing reveals complex genomic and transcriptomic changes in AAV-CRISPR therapy for Duchenne Muscular Dystrophy
- Optimizing Recombinant Cas9 Expression: Insights from E. coli BL21(DE3) Strains for Enhanced Protein Purification and Genome Editing
- Standardizing a Protocol for Streamlined Synthesis and Characterization of Lipid Nanoparticles to Enable Preclinical Research and Education
- A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct
- Beyond the Cut: Long-read sequencing reveals complex genomic and transcriptomic changes in AAV-CRISPR therapy for Duchenne Muscular Dystrophy
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
- Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy
- A Dual-Fluorescence Assay for Gene Delivery Vehicle Screening in Macrophages with an Inflammation-Inducible Reporter Construct
- A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci
- Beyond the Cut: Long-read sequencing reveals complex genomic and transcriptomic changes in AAV-CRISPR therapy for Duchenne Muscular Dystrophy
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
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