Carl E. Cerniglia
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Also affiliated: Merck & Co., Inc., Rahway, NJ, USA (United States) (2020); Center for Food Safety and Applied Nutrition (2010); Center for Veterinary Medicine (2004); United States Food and Drug Administration (1981–2024); North Carolina State University (1973–1974); Uniformed Services University of the Health Sciences (1983–1993); Georgia State University (1993); Hebrew University of Jerusalem (1996); Fundação Oswaldo Cruz (2003); Centro de Investigación Científica y de Educación Superior de Ensenada (2007); Friedrich Schiller University Jena (1997); The University of Texas at Austin (1978–1988)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Carl E. Cerniglia's research has primarily focused on the microbial metabolism and biodegradation of various organic compounds, including polycyclic aromatic hydrocarbons (PAHs) and azo dyes. His work investigates the biotransformation processes carried out by microorganisms, particularly within the intestinal tract of humans and animals. Cerniglia has employed techniques such as high-pressure liquid chromatography, mass spectrometry, and magnetic resonance spectroscopy to identify and characterize metabolites. He has also utilized polymerase chain reaction (PCR) for the detection and quantification of bacterial populations in fecal samples, contributing to the understanding of gut microbiota composition and function.
His publications include studies on the mutagenicity of azo dyes and the structure-activity relationships involved. Cerniglia has also explored the potential applications of microbial degradation in bioremediation, examining fungal metabolism of PAHs. His research network includes collaborators from the National Center for Toxicological Research, with whom he has co-authored multiple publications. Cerniglia's extensive publication record and high citation count indicate a significant contribution to the fields of toxicology and environmental microbiology.
Metrics
- h-index: 86
- Publications: 407
- Citations: 26,252
Selected Publications
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Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome (2024)
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Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes (2021)
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Pragmatic Strategy for Fecal Specimen Storage and the Corresponding Test Methods for Clostridioides difficile Diagnosis (2021)
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Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model (2021)
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Dynamic Adaptive Response of Pseudomonas aeruginosa to Clindamycin/Rifampicin-Impregnated Catheters (2021)
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Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes (2021)
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Antimicrobial drug residues in animal‐derived foods: Potential impact on the human intestinal microbiome (2020)
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Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high‐fat diet in the genetically diverse Collaborative Cross mouse model (2020)
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Alteration in the mRNA expression of genes associated with gastrointestinal permeability and ileal TNF-α secretion due to the exposure of silver nanoparticles in Sprague–Dawley rats (2019)
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Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status (2018)
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An in vitro study to assess the impact of tetracycline on the human intestinal microbiome (2017)
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Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells (2017)
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Evaluation of metabolism of azo dyes and their effects onStaphylococcus aureusmetabolome (2017)
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Comparative genomic analysis and characterization of incompatibility group FIB plasmid encoded virulence factors of Salmonella enterica isolated from food sources (2017)
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Characterizing chronic and acute health risks of residues of veterinary drugs in food: latest methodological developments by the joint FAO/WHO expert committee on food additives (2017)
Collaboration Network
Top Collaborators
- Pyrene degradation by a Mycobacterium sp.: identification of ring oxidation and ring fission products
- Effects of pH on the degradation of phenanthrene and pyrene by Mycobacterium vanbaalenii PYR-1
- Metabolism of phenanthrene by Phanerochaete chrysosporium
- Identification of metabolites from the degradation of fluoranthene by Mycobacterium sp. strain PYR-1
- Metabolism of anthracene by aRhodococcusspecies
Showing 5 of 26 shared publications
- Molecular characterization of a phenanthrene degradation pathway in Mycobacterium vanbaalenii PYR-1
- Detection of Pseudomonas aeruginosa from clinical and environmental samples by amplification of the exotoxin A gene using PCR
- Detection of multidrug-resistantSalmonella typhimuriumDT104 by multiplex polymerase chain reaction
- Molecular characterization of dioxygenases from polycyclic aromatic hydrocarbon-degrading Mycobacterium spp.
- Novel organization of genes in a phthalate degradation operon of Mycobacterium vanbaalenii PYR-1
Showing 5 of 13 shared publications
- Biochemical and molecular characterization of an azoreductase from Staphylococcus aureus, a tetrameric NADPH-dependent flavoprotein
- Molecular cloning, overexpression, purification, and characterization of an aerobic FMN-dependent azoreductase from Enterococcus faecalis
- Sudan azo dyes and Para Red degradation by prevalent bacteria of the human gastrointestinal tract
- Metabolism of azo dyes by human skin microbiota
- Evaluation of impact of exposure of Sudan azo dyes and their metabolites on human intestinal bacteria
Showing 5 of 12 shared publications
- A new classification system for bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases
- Genomic analysis of polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1
- Polycyclic Aromatic Hydrocarbon Metabolic Network in Mycobacterium vanbaaleniiPYR-1
- Molecular characterization of cytochrome P450 genes in the polycyclic aromatic hydrocarbon degrading Mycobacterium vanbaalenii PYR-1
- Proteomic applications to elucidate bacterial aromatic hydrocarbon metabolic pathways
Showing 5 of 12 shared publications
- Degradation of Polycyclic Aromatic Hydrocarbons by Fungi
- Metabolism of phenanthrene by Phanerochaete chrysosporium
- Stereoselective formation of a K-region dihydrodiol from phenanthrene by Streptomyces flavovirens
- Use of a bioassay to evaluate the toxicity of beauvericin to bacteria
- Comparative functional pan-genome analyses to build connections between genomic dynamics and phenotypic evolution in polycyclic aromatic hydrocarbon metabolism in the genus Mycobacterium
Showing 5 of 11 shared publications
- Azoreductase activity of anaerobic bacteria isolated from human intestinal microflora
- Microbial metabolism of polycyclic aromatic hydrocarbons: isolation and characterization of a pyrene-degrading bacterium
- Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract
- Metabolism of azo dyes derived from benzidine, 3,3'-dimethylbenzidine and 3,3' -dimethoxybenzidine to potentially carcinogenic aromatic amines by intestinal bacteria
- Reclassification of a Polycyclic Aromatic Hydrocarbon-Metabolizing Bacterium, Beijerinckia sp. Strain B1, as Sphingomonas yanoikuyae by Fatty Acid Analysis, Protein Pattern Analysis, DNA-DNA Hybridization, and 16S Ribosomal DNA Sequencing
Showing 5 of 10 shared publications
- Sudan azo dyes and Para Red degradation by prevalent bacteria of the human gastrointestinal tract
- Metabolism of azo dyes by human skin microbiota
- Reduction of malachite green to leucomalachite green by intestinal bacteria
- A kinetic study on the degradation of erythromycin A in aqueous solution
- Initial oxidative and subsequent conjugative metabolites produced during the metabolism of phenanthrene by fungi
Showing 5 of 10 shared publications
- Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium
- Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status
- METABOLIC PATHWAYS | Production of Secondary Metabolites of Bacteria
- Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells
- An in vitro study to assess the impact of tetracycline on the human intestinal microbiome
Showing 5 of 9 shared publications
- Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium
- Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status
- METABOLIC PATHWAYS | Production of Secondary Metabolites of Bacteria
- Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells
- An in vitro study to assess the impact of tetracycline on the human intestinal microbiome
Showing 5 of 8 shared publications
- A new classification system for bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases
- Genomic analysis of polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1
- Polycyclic Aromatic Hydrocarbon Metabolic Network in Mycobacterium vanbaaleniiPYR-1
- Proteomic applications to elucidate bacterial aromatic hydrocarbon metabolic pathways
- Functional Robustness of a Polycyclic Aromatic Hydrocarbon Metabolic Network Examined in anidAAromatic Ring-Hydroxylating Oxygenase Mutant of Mycobacterium vanbaalenii PYR-1
Showing 5 of 8 shared publications
- Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp
- Molecular characterization of multidrug-resistant Enterococcus spp. from poultry and dairy farms: detection of virulence and vancomycin resistance gene markers by PCR
- Physical, biochemical, and immunological characterization of a thermostable amidase from Klebsiella pneumoniae NCTR 1
- Metabolism of acrylonitrile by Klebsiella pneumoniae
- Transfer of Erythromycin Resistance from Poultry to Human Clinical Strains ofStaphylococcus aureus
Showing 5 of 7 shared publications
- Effects of pH on the degradation of phenanthrene and pyrene by Mycobacterium vanbaalenii PYR-1
- A kinetic study on the degradation of erythromycin A in aqueous solution
- Purification and characterization of an erythromycin esterase from an erythromycin-resistantPseudomonassp.
- Two polycyclic aromatic hydrocarbon o-quinone reductases from a pyrene-degrading Mycobacterium
- Evidence for the existence of PAH-quinone reductase and catechol-O-methyltransferase in Mycobacterium vanbaalenii PYR-1
Showing 5 of 7 shared publications
- Metabolism of phenanthrene by Phanerochaete chrysosporium
- Identification of metabolites from the degradation of fluoranthene by Mycobacterium sp. strain PYR-1
- Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans
- Fungal transformation of fluoranthene
- Fungal metabolism of acenaphthene by Cunninghamella elegans
Showing 5 of 6 shared publications
- Utilization of mixtures of polycyclic aromatic hydrocarbons by bacteria isolated from contaminated sediment
- Effects of pH on the degradation of phenanthrene and pyrene by Mycobacterium vanbaalenii PYR-1
- Metabolism of anthracene by aRhodococcusspecies
- Degradation of benz[a]anthracene by Mycobacterium vanbaalenii strain PYR-1
- Evidence for the existence of PAH-quinone reductase and catechol-O-methyltransferase in Mycobacterium vanbaalenii PYR-1
Showing 5 of 6 shared publications
- Identification of metabolites from the degradation of fluoranthene by Mycobacterium sp. strain PYR-1
- Identification of metabolites from degradation of naphthalene by a Mycobacterium sp.
- Degradation of a mixture of high‐molecular‐weight polycyclic aromatic hydrocarbons by aMycobacteriumstrain PYR‐1
- Identification of a Carboxylic Acid Metabolite from the Catabolism of Fluoranthene by a Mycobacterium sp
- The metabolism of fluoranthene by a species ofMycobacterium
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