Biography and Research Information
OverviewAI-generated summary
Sangeeta Khare's research focuses on the toxicological effects of various substances and materials on the gastrointestinal system, with a particular emphasis on the gut microbiome and intestinal epithelial cells. Her work has investigated the impact of co-exposures, such as to pesticides and nanoparticles, on gene expression related to cell junctions and the translocation of substances across the intestinal barrier. Khare has also examined the effects of chronic exposure to antibiotics, like tetracycline, on human intestinal microbiota using in vitro bioreactor models.
Further research by Khare explores the influence of different routes of exposure to compounds like arsenic on immune responses and gut permeability. She has developed preclinical in vitro models to assess changes in intestinal epithelial cell permeability and cytotoxicity under conditions mimicking oral or intravenous administration. Her publications also touch upon the broader relevance of gut microbiome research in food safety assessments and the conformational changes of viral proteins, such as the SARS-CoV-2 spike protein.
Metrics
- h-index: 28
- Publications: 118
- Citations: 8,671
Selected Publications
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Silver nanoparticles at sub-cytotoxic levels increase enteric pathogen invasion by compromising intestinal epithelial barrier integrity (2026)
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Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner (2025)
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Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring (2025)
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Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease (2025)
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Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring (2025)
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Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration (2025)
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Relevance of gut microbiome research in food safety assessment (2024)
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Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model (2024)
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Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome (2024)
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Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats (2023)
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Relevance of gut microbiome research in food safety assessment (2023)
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Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability (2023)
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Structural analysis of VirD4 a type IV ATPase encoded by transmissible plasmids of Salmonella enterica isolated from poultry products (2022)
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The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials (2022)
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Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure (2022)
Collaboration Network
Top Collaborators
Kuppan Gokulan
National Center for Toxicological Research
18 shared publications
In database
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Co-exposure to boscalid and TiO2 (E171) or SiO2 (E551) downregulates cell junction gene expression in small intestinal epithelium cellular model and increases pesticide translocation
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
Showing 5 of 18 shared publications
Chandra Mohan Reddy Muthumula
5 shared publications
In database
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Engineering Nanocrystal Formulations through Excipient Selection Strategies
Yaswanthi Yanamadala
National Center for Toxicological Research
5 shared publications
In database
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Engineering Nanocrystal Formulations through Excipient Selection Strategies
- Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner
S. Chakder
Center for Drug Evaluation and Research (US)
3 shared publications
- Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats
- P22-20 Risk assessment of Nanocrystal Formulated Zileuton (a poorly soluble BCS-II oral drug) using In Vivo Model
- P24-25: Comparative Pharmacokinetics and Safety Assessment of Nanocrystal Formulated Zileuton at the Gastrointestinal Tract Reveals Sex-Dependent Mucosal Immune Response, Epithelial Permeability and Drug Metabolism in Sprague Dawley Rats
Vicki Sutherland
National Institute of Environmental Health Sciences (US)
3 shared publications
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
Helen Cunny
National Institute of Environmental Health Sciences (US)
3 shared publications
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
Kumari Karn
Microbiology Society
3 shared publications
In database
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
Pravin Parajuli
United States Food and Drug Administration
2 shared publications
In database
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure
Carl E. Cerniglia
National Center for Toxicological Research
2 shared publications
In database
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
Mohamed H. Lahiani
United States Food and Drug Administration
2 shared publications
In database
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
Katherine M. Williams
United States Food and Drug Administration (US)
2 shared publications
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
- The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials
Anshel Bright
National Center for Toxicological Research
2 shared publications
In database
- Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats
- P22-20 Risk assessment of Nanocrystal Formulated Zileuton (a poorly soluble BCS-II oral drug) using In Vivo Model
K.J. Harris
National Center for Toxicological Research
2 shared publications
In database
- P22-20 Risk assessment of Nanocrystal Formulated Zileuton (a poorly soluble BCS-II oral drug) using In Vivo Model
- Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner
K. Gokulan
National Center for Toxicological Research (US)
2 shared publications
- P22-20 Risk assessment of Nanocrystal Formulated Zileuton (a poorly soluble BCS-II oral drug) using In Vivo Model
- Silver nanoparticles at sub-cytotoxic levels increase enteric pathogen invasion by compromising intestinal epithelial barrier integrity
Manuel Garrido‐Romero
Instituto de Investigación en Ciencias de la Alimentación (ES)
2 shared publications
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
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