Alison Simmons

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Alison Simmons' research investigates the complexities of human health, with a particular focus on the gastrointestinal tract and immune system. Her work includes spatiotemporal analysis of human intestinal development at a single-cell level, contributing to a broader understanding of the Human Gut Cell Atlas. Simmons has studied the role of GSDMB in inflammatory bowel disease (IBD), noting its regulation of epithelial restitution and repair independently of pyroptosis. Her research also examines the function of interferon-gamma-producing CD8+ tissue-resident memory T cells as a target in immune checkpoint inhibitor-induced colitis.

Further contributing to the field of immunology, Simmons has characterized monocytes in idiopathic pulmonary fibrosis, revealing a primed type I interferon immune phenotype. Her investigations extend to the bone morphogenetic protein pathway and its regulation of epithelial cell fate during intestinal regeneration, as well as the interaction between Intelectin-1 and the mucus barrier-modifying bacterium Akkermansia muciniphila. Simmons also has experience in medical imaging, with a pilot study on the automatic three-dimensional quantification of Barrett’s esophagus for risk stratification and therapy monitoring.

Simmons holds designations as a high-impact, highly cited researcher. She collaborates with colleagues at the University of Arkansas at Fayetteville, including Amanda Troillett and Andrew N. J. McKenzie. Her scholarly output includes 169 publications, accumulating over 15,000 citations and an h-index of 45.

Metrics

• h-index: 45
• Publications: 169
• Citations: 15,162