Sandra G. Morrison

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UAMS primary University of Arkansas

Also affiliated: National Institutes of Health (1989–1997); Austrian Academy of Sciences (2003); Innsbruck Medical University (2003); Universität Innsbruck (2003); Utrecht University (2003); Montana State University (1999–2005); University of Alabama at Birmingham (1996–2008); National Institute of Allergy and Infectious Diseases (1989–1997)

31 h-index 46 pubs 4,323 cited

Research Areas

Biomedical Subjects

OverviewAI-generated summary

Sandra G. Morrison's research has focused on microbial infections and the human immune response, with a significant body of work investigating Chlamydia trachomatis and Human Immunodeficiency Virus type 1 (HIV-1). Her studies on *Chlamydia* have explored the role of heat shock proteins in activating immune cells, such as macrophages and endothelial cells, through Toll-like receptor 4 (TLR4) and myeloid differentiation factor 2 (MD-2) in a MyD88-dependent pathway. She has also investigated the components of acquired immunity to *Chlamydia* genital tract reinfection, identifying the involvement of B cells and CD4+ T cells, and highlighting a predominant role for antibodies.

Morrison's work on HIV-1 has contributed to understanding the genetic diversity of the virus. She has analyzed functional envelope genes from various HIV-1 subtypes (A through G) and developed comprehensive panels of near-full-length clones and reference sequences for non-subtype B isolates. This research aided in characterizing the heterosexual HIV-1 epidemic in Thailand, identifying an intersubtype (A/E) recombinant of African origin. Her scholarship metrics include an h-index of 31, with 53 publications and over 4,350 citations, reflecting sustained contributions to her fields.

Metrics

h-index: 31
Publications: 46
Citations: 4,323

Selected Publications

Tail-specific protease is an essential Chlamydia virulence factor that mediates the differentiation of elementary bodies into reticulate bodies (2024)

Infection and Immunity 4 citations DOI OpenAlex
Prevalence of Chlamydia trachomatis Infection in Young Women and Associated Predictors (2021)

Sexually Transmitted Diseases 14 citations DOI OpenAlex
A Genital Infection-Attenuated Chlamydia muridarum Mutant Infects the Gastrointestinal Tract and Protects against Genital Tract Challenge (2020)

mBio 28 citations DOI OpenAlex
Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture (2019)

OpenAlex
Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture (2019)

mBio 30 citations DOI OpenAlex
Chlamydia muridarum Genital and Gastrointestinal Infection Tropism Is Mediated by Distinct Chromosomal Factors (2018)

PMC OpenAlex
Chlamydia muridarum Genital and Gastrointestinal Infection Tropism Is Mediated by Distinct Chromosomal Factors (2018)

Infection and Immunity 19 citations DOI OpenAlex
Nonpathogenic Colonization with Chlamydia in the Gastrointestinal Tract as Oral Vaccination for Inducing Transmucosal Protection (2017)

Infection and Immunity 61 citations DOI OpenAlex
Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia (2017)

Infection and Immunity 45 citations DOI OpenAlex
Interferon-gamma and Effector Cell Activation are Required for Antibody-Mediated Immunity against Genital Chlamydia Infection (2016)

The Journal of Immunology DOI OpenAlex
Gamma Interferon Is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia Infection (2016)

Infection and Immunity 58 citations DOI OpenAlex
Mutational Analysis of the Chlamydia muridarum Plasticity Zone (2015)

IUScholarWorks (Indiana University) OpenAlex
Mutational Analysis of the Chlamydia muridarum Plasticity Zone (2015)

Infection and Immunity 55 citations DOI OpenAlex
Immunoglobulin-Specific Responses to Chlamydia Elementary Bodies in Individuals with and at Risk for Genital Chlamydial Infection (2012)

The Journal of Infectious Diseases 62 citations DOI OpenAlex
Murine Chlamydia trachomatis Genital Infection Is Unaltered by Depletion of CD4+ T cells and Diminished Adaptive Immunity (2011)

The Journal of Infectious Diseases 41 citations DOI OpenAlex