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Biography and Research Information
OverviewAI-generated summary
Adriana Lelis Carvalho's research investigates the physiological and pathophysiological roles of mitochondria and reactive oxygen species (ROS) in various biological contexts. Her work has explored mitochondrial function alterations during the progression of non-alcoholic fatty liver disease (NAFLD), demonstrating how mitochondria-targeted antioxidants can mitigate liver steatosis by influencing lipid accumulation and fatty acid oxidation. Carvalho's research also extends to bone cell physiology, examining the impact of ROS and the NAD salvage pathway on skeletal development. She has investigated the influence of specific proteins, such as ECSIT, on osteoclast differentiation and mitochondrial stimulation, and the role of TRPM8 in temperature regulation and its potential effects on bone loss. Her scholarship includes 25 publications with 534 citations, and an h-index of 14. Carvalho collaborates with several researchers at the University of Arkansas for Medical Sciences, including Maria Almeida and Ha-Neui Kim, with whom she has co-authored multiple publications.
Metrics
- h-index: 14
- Publications: 25
- Citations: 557
Selected Publications
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The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025)
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CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength (2024)
Collaboration Network
Top Collaborators
Maria Almeida
University of Arkansas for Medical Sciences
6 shared publications
In database
- The role of reactive oxygen species in bone cell physiology and pathophysiology
- ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens
- The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice
- Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Showing 5 of 6 shared publications
Ha‐Neui Kim
University of Arkansas for Medical Sciences
5 shared publications
In database
- The role of reactive oxygen species in bone cell physiology and pathophysiology
- ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens
- The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice
- Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Daniel J. Brooks
Beth Israel Deaconess Medical Center (US)
3 shared publications
- TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss
- Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Mice
- Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice
Mary Bouxsein
Beth Israel Deaconess Medical Center (US)
3 shared publications
- TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss
- Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Mice
- Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice
Katherine J. Motyl
University of Maine (US)
3 shared publications
- TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss
- Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Mice
- Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice
Ricardo Amorim
University of Coimbra (PT)
3 shared publications
- The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production
- Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
- Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells
Inês C. M. Simões
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
3 shared publications
- The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production
- Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
- Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells
Rui F. Simões
University of Coimbra (PT)
3 shared publications
- The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production
- Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
- Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells
Mariusz R. Wiȩckowski
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
3 shared publications
- The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production
- Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
- Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells
José Teixeira
University of Coimbra (PT)
3 shared publications
- The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production
- Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
- Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells
Paulo J. Oliveira
University of Coimbra (PT)
3 shared publications
- The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production
- Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
- Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells
Deborah Barlow
University of New England (US)
2 shared publications
- Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Mice
- Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice
Karen L. Houseknecht
University of Maine (US)
2 shared publications
- Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Mice
- Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice
Jane B. Lian
MaineHealth (US)
2 shared publications
- Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Mice
- Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice
Tamara King
University of Maine (US)
2 shared publications
- Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Mice
- Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice
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