R
Rose Willett Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Staff Research fellow
postdoc
12 h-index
21 pubs
846 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Rose Willett's research focuses on the molecular and cellular alterations associated with non-alcoholic fatty liver disease (NAFLD) and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH). Her work investigates the impact of high-fat and high-sucrose diets on hepatic gene expression, lipid composition, and DNA methylation in genetically diverse mouse models, specifically the Collaborative Cross mice. Willett has also explored these changes in human hepatocellular cell models. Her recent publications examine the role of TMEM55B in cellular stress responses, linking autophagy flux and lysosomal repair to oxidative stress. She collaborates extensively with researchers at the National Center for Toxicological Research, including Volodymyr Tryndyak and Igor P. Pogribny, with whom she has co-authored multiple publications. Willett's scholarship metrics include an h-index of 12, 21 total publications, and 837 total citations.
Metrics
- h-index: 12
- Publications: 21
- Citations: 846
Selected Publications
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Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025)
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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023)
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Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023)
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Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023)
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Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022)
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Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022)
Collaboration Network
Top Collaborators
Volodymyr Tryndyak
National Center for Toxicological Research
8 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification
Showing 5 of 8 shared publications
Igor P. Pogribny
National Center for Toxicological Research
8 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification
Showing 5 of 8 shared publications
Frederick A. Beland
National Center for Toxicological Research
7 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification
Showing 5 of 7 shared publications
Ivan Rusyn
Texas A&M University (US)
6 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Showing 5 of 6 shared publications
Mark Avigan
United States Food and Drug Administration (US)
5 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Suresh K. Nagumalli
National Center for Toxicological Research
3 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Gonçalo Gamboa da Costa
National Center for Toxicological Research
2 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
J. Hanks
National Center for Toxicological Research
2 shared publications
In database
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Zhiqiang Song
North Carolina State University (US)
2 shared publications
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
- Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model
Fred A. Wright
North Carolina State University (US)
2 shared publications
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
- Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model
Arun J. Sanyal
Virginia Commonwealth University (US)
1 shared publication
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
Aline de Conti
National Center for Toxicological Research (US)
1 shared publication
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
Dan Li
National Center for Toxicological Research (US)
1 shared publication
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
Todd Bourcier
1 shared publication
- Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin
Eutteum Jeong
National Heart Lung and Blood Institute (US)
1 shared publication
- TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress
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