Rose Willett Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Staff Research fellow

National Center for Toxicological Research

postdoc

12 h-index 21 pubs 813 cited

Research Areas

Liver Disease Diagnosis and Treatment Diet and metabolism studies Epigenetics and DNA Methylation Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications Immune Response and Inflammation Metabolomics and Mass Spectrometry Studies

Links

ORCID Research Group

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OverviewAI-generated summary

Rose Willett's research focuses on the molecular and cellular mechanisms underlying nonalcoholic fatty liver disease (NAFLD) and related conditions, particularly in the context of diet-induced metabolic injury. She has investigated the impact of high-fat and high-sucrose diets on hepatic gene expression, lipid composition, and the development of nonalcoholic steatohepatitis (NASH)-like liver injury in mouse models. Her work has also explored cellular and molecular alterations in human hepatocellular models of NAFLD and the role of the TMEM55B protein in cellular stress responses, including autophagy flux and lysosomal repair.

Willett has published findings related to DNA methylation and gene expression alterations in the livers of genetically diverse mice fed obesogenic diets. Her research utilizes various experimental approaches to evaluate liver injury signatures and mediation analysis of molecular phenotypes in preclinical models. She collaborates with researchers at the National Center for Toxicological Research, including Volodymyr Tryndyak and Igor P. Pogribny, on multiple shared publications.

Metrics

  • h-index: 12
  • Publications: 21
  • Citations: 813

Selected Publications

  • Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025) DOI
  • Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025) DOI
  • A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024) DOI
  • Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023) DOI
  • Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023) DOI
  • Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023) DOI
  • Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022) DOI
  • Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022) DOI

Collaborators

Researchers in the database who share publications

Volodymyr Tryndyak National Center for Toxicological Research 8 shared publications Igor P. Pogribny National Center for Toxicological Research 8 shared publications Frederick A. Beland National Center for Toxicological Research 7 shared publications Suresh K. Nagumalli National Center for Toxicological Research 3 shared publications Gonçalo Gamboa da Costa National Center for Toxicological Research 2 shared publications J. Hanks National Center for Toxicological Research 2 shared publications

Similar Researchers

Based on overlapping research topics

Melisa Kozaczek University of Arkansas for Medical Sciences
Liver Disease Diagnosis and Treatment Diet and metabolism studies Pharmacological Effects and Toxicity Studies
Good match 4 shared topics
Volodymyr Tryndyak National Center for Toxicological Research
Liver Disease Diagnosis and Treatment Diet and metabolism studies Epigenetics and DNA Methylation
Good match 5 shared topics
Melissa M. Clemens University of Arkansas for Medical Sciences
Liver Disease Diagnosis and Treatment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Good match 4 shared topics
Igor P. Pogribny National Center for Toxicological Research
Liver Disease Diagnosis and Treatment Diet and metabolism studies Epigenetics and DNA Methylation
Good match 5 shared topics
Diyana Albataineh University of Arkansas at Fayetteville
Liver Disease Diagnosis and Treatment Diet and metabolism studies Pharmacological Effects and Toxicity Studies
Good match 4 shared topics
Ashim K. Bagchi University of Arkansas for Medical Sciences
Diet and metabolism studies Pharmacological Effects and Toxicity Studies Immune Response and Inflammation
Good match 4 shared topics