K
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Karl D. Straub's research investigates the biochemical reactions of hydrogen sulfide (H2S) with quinones, particularly focusing on how polyphenols, coenzyme Q10, and naphthoquinones facilitate the oxidation of H2S to polysulfides and thiosulfate. This work explores novel mechanisms underlying the biological actions of various compounds, including antioxidant nutraceuticals, and their effects on cellular sulfur metabolism and signaling. His investigations delve into the reaction mechanisms of H2S oxidation by naphthoquinones, with implications for potential therapeutic applications.
Straub has published extensively on these topics, with his recent work appearing in journals such as Free Radical Biology and Medicine and Redox Biology. His scholarship metrics include an h-index of 28 and over 2,800 citations from 135 publications, recognizing him as a highly cited researcher. He maintains an active laboratory website to share his research findings.
Metrics
- h-index: 28
- Publications: 135
- Citations: 2,846
Selected Publications
-
The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase (2024)
-
Reaction Mechanisms of H2S Oxidation by Naphthoquinones (2024)
-
Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate (2023)
-
Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications (2022)
-
Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate (2022)
-
‘Antioxidant’ berries, anthocyanins, resveratrol and rosmarinic acid oxidize hydrogen sulfide to polysulfides and thiosulfate: A novel mechanism underlying their biological actions (2021)
-
Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects (2021)
Collaboration Network
Top Collaborators
Kenneth R. Olson
Indiana University South Bend (US)
8 shared publications
- Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects
- ‘Antioxidant’ berries, anthocyanins, resveratrol and rosmarinic acid oxidize hydrogen sulfide to polysulfides and thiosulfate: A novel mechanism underlying their biological actions
- Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
Showing 5 of 8 shared publications
Kasey J. Clear
Indiana University South Bend (US)
5 shared publications
- Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
- Reaction Mechanisms of H2S Oxidation by Naphthoquinones
- The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase
Zhilin Ma
Indiana University South Bend (US)
5 shared publications
- Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
- Reaction Mechanisms of H2S Oxidation by Naphthoquinones
- The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase
Gang Wu
5 shared publications
- Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
- Reaction Mechanisms of H2S Oxidation by Naphthoquinones
- The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase
Thomas A. Kent
4 shared publications
- Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling
- The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase
Yan Gao
Indiana University South Bend (US)
4 shared publications
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
- Reaction Mechanisms of H2S Oxidation by Naphthoquinones
- The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase
Ella Pfaff
University of Notre Dame (US)
4 shared publications
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
- Reaction Mechanisms of H2S Oxidation by Naphthoquinones
- The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase
Yan Gao
Indiana University South Bend (US)
3 shared publications
- Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects
- ‘Antioxidant’ berries, anthocyanins, resveratrol and rosmarinic acid oxidize hydrogen sulfide to polysulfides and thiosulfate: A novel mechanism underlying their biological actions
- Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
Paul J. Derry
Texas A&M Health Science Center (US)
3 shared publications
- Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling
Stephen M. Kasko
Indiana University School of Medicine
3 shared publications
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
- Reaction Mechanisms of H2S Oxidation by Naphthoquinones
Brian P. Villa
University of Notre Dame (US)
2 shared publications
- ‘Antioxidant’ berries, anthocyanins, resveratrol and rosmarinic acid oxidize hydrogen sulfide to polysulfides and thiosulfate: A novel mechanism underlying their biological actions
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
Nathaniel M. Cieplik
University of Notre Dame (US)
2 shared publications
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
Alyssa R. Fiume
University of Notre Dame (US)
2 shared publications
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
Dominic J. Gaziano
Indiana University School of Medicine
2 shared publications
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
Cecilia L. Velander
University of Notre Dame (US)
2 shared publications
- Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate
Similar Researchers
Based on overlapping research topics
Haven Griffin
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Receptor Mechanisms and Signaling
Jia‐Long Fang
National Center for Toxicological Research
Metabolism and Genetic Disorders
Phytochemicals and Antioxidant Activities
Disease Mechanisms Research
Jiaojiao Fan
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Mitochondrial Function and Pathology
Vivek Khanal
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Receptor Mechanisms and Signaling
Emily E. Rothacker
University of Arkansas at Fayetteville
Metabolism and Genetic Disorders
Disease Mechanisms Research
Mitochondrial Function and Pathology
Rushita A. Bagchi
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Mitochondrial Function and Pathology