Amit K. Tiwari
Associate Dean and Professor
University of Arkansas for Medical Sciences
faculty
COP | College of Pharmacy
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Amit K. Tiwari's research focuses on drug delivery systems, nanomedicine, and the pharmacological applications of natural compounds, particularly in the context of cancer and neurodegenerative diseases. His work investigates novel strategies for delivering therapeutic agents, including the use of nanoparticles, micelles, and transdermal systems. He has published research on resveratrol-loaded nanomedicines for cancer applications and explored the potential of curcumin-resveratrol nanoparticles for synergistic inhibition of melanoma cell proliferation.
Tiwari also contributes to the study of molecular mechanisms in disease, with publications addressing m6A modification in cancer targeted drug discovery and the role of nitrogen heterocycles in Alzheimer's disease drug discovery. His research extends to the therapeutic management of Alzheimer's disease using traditional medicinal plants. With a significant publication record (388 publications, 8,261 citations, h-index of 45), Tiwari is recognized as a highly cited researcher and leads an active research group at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 45
- Publications: 388
- Citations: 8,261
Selected Publications
- Synergistic strategies: histone deacetylase inhibitors and platinum-based drugs in cancer therapy (2025) DOI
- Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer (2024) DOI
- Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery (2024) DOI
- Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants (2024) DOI
- Rapidly Dissolving Trans-scleral Microneedles for Intraocular Delivery of Cyclosporine A (2024) DOI
- Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease: opportunities and challenges (2023) DOI
- Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy (2023) DOI
- Dual inhibitors of HDAC and other epigenetic regulators: A novel strategy for cancer treatment (2023) DOI
- Targeting ferroptosis in gastric cancer: Strategies and opportunities (2023) DOI
Research Interests
Dr. Tiwari is an Associate Dean of Research & Graduate Studies and a Professor of Pharmaceutical Sciences in the College of Pharmacy at University of Arkansas for Medical Sciences, Arkansas. He is a seasoned pharmacologist, a board-certified toxicologist and also leads a funded ?Cancer and Systems Therapeutics (CAST) program. He has been widely cited and has published, over 240 peer reviewed publications, patents and book chapters. CAST team is involved in a) developing effective, safe, and targeted anticancer molecules against multidrug-resistant cancers; b) designing, synthesizing and characterizing non-conventional forms of cell death inducers. CAST team has discovered first-in-class, safe agents that activate necroptosis, methuosis, methuophagy, ferroptosis, entosis, and immunogenic cell death, sensitizing resistant cancers to immuno- and radiotherapies. Integrating biomimetic microfluidics, high-content imaging, and AI-driven analytics, his group develops predictive tools to understand and overcome chemotherapy failure. In parallel, they are advancing patented macropinocytosis-based delivery platforms that enhance intracellular transport of siRNAs and proteins. Supported by multiple federal and foundation grants, issued patents, and international collaborations, Dr. Tiwari’s translational program bridges preclinical innovation with therapeutic impact.; Drug Discovery; Drug Resistance; Non Apoptotic Cell Death; Formulations, Drug; Drug Delivery Systems; Intellectual Properties
Grants & Funding
- Development of Novel Inducers of Non-Apoptotic Cell Death to Target TNBC US Department of Defense Principal Investigator
- High-throughput high-resolution microscopy for phenotypic drug discovery applications NIH/Nat. Inst. of Biomedical Imaging & Bioengineering - Pass Through: University of Toledo Principal Investigator
- ABI A. Tiwari Startup FY26 Y3 State of Arkansas Principal Investigator
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