Biography and Research Information
OverviewAI-generated summary
Ashley V. Nywening's research focuses on fungal pathogens, particularly *Aspergillus fumigatus*, and the mechanisms underlying their virulence and susceptibility to antifungal agents. Nywening has investigated the role of specific fungal genes and proteins in cellular processes such as cell wall homeostasis, tissue invasion, and morphogenesis. Their work has explored secondary mechanisms of action for triazole antifungals, including the involvement of the *hmg1* gene, and has identified essential genes like *erg6* for fungal viability. Furthermore, Nywening has studied the regulation of signaling pathways, such as the septation initiation network (SIN), and their impact on antifungal drug efficacy. This research contributes to understanding fungal disease mechanisms and identifying potential therapeutic targets. Nywening's publication record includes studies on zoonotic spillover and disease emergence, broadening the scope of their infectious disease research.
Metrics
- h-index: 7
- Publications: 17
- Citations: 271
Selected Publications
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Genetic analysis of common triazole resistance mechanisms in a collection of <i>Aspergillus lentulus</i> clinical isolates from the United States (2025)
Collaboration Network
Top Collaborators
Adela Martín‐Vicente
University of Tennessee Health Science Center (US)
10 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in <i>Aspergillus fumigatus</i>
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity
Showing 5 of 10 shared publications
Jarrod R. Fortwendel
University of Tennessee Health Science Center (US)
10 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in <i>Aspergillus fumigatus</i>
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity
Showing 5 of 10 shared publications
Jinhong Xie
University of Tennessee Health Science Center (US)
9 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in <i>Aspergillus fumigatus</i>
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity
- The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
Showing 5 of 9 shared publications
Xabier Guruceaga
Universidad de Navarra (ES)
9 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in <i>Aspergillus fumigatus</i>
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity
- The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
Showing 5 of 9 shared publications
Harrison I. Thorn
University of Tennessee Health Science Center (US)
9 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in <i>Aspergillus fumigatus</i>
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity
- The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
Showing 5 of 9 shared publications
Wenbo Ge
St. Jude Children's Research Hospital (US)
7 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in <i>Aspergillus fumigatus</i>
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity
Showing 5 of 7 shared publications
Ana Camila Oliveira Souza
St. Jude Children's Research Hospital (US)
3 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity
Jeffrey M. Rybak
St. Jude Children's Research Hospital (US)
3 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- The sterol C-24 methyltransferase encoding gene, <i>erg6</i> , is essential for viability of <i>Aspergillus</i> species
Josie E. Parker
Cardiff University (GB)
3 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- The sterol C-24 methyltransferase encoding gene, <i>erg6</i> , is essential for viability of <i>Aspergillus</i> species
Steven L. Kelly
Swansea University (GB)
3 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- The sterol C-24 methyltransferase encoding gene, <i>erg6</i> , is essential for viability of <i>Aspergillus</i> species
P. David Rogers
St. Jude Children's Research Hospital (US)
3 shared publications
- A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
- The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species
- The sterol C-24 methyltransferase encoding gene, <i>erg6</i> , is essential for viability of <i>Aspergillus</i> species
Uxue Perez‐Cuesta
University of the Basque Country (ES)
2 shared publications
- The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
- The <i>Aspergillus fumigatus maiA</i> gene contributes to cell wall homeostasis and fungal virulence
Eduardo Pelegri‐Martinez
University of the Basque Country (ES)
2 shared publications
- The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
- The <i>Aspergillus fumigatus maiA</i> gene contributes to cell wall homeostasis and fungal virulence
Saioa Cendon‐Sanchez
University of the Basque Country (ES)
2 shared publications
- The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
- The <i>Aspergillus fumigatus maiA</i> gene contributes to cell wall homeostasis and fungal virulence
Andoni Ramirez‐Garcia
University of the Basque Country (ES)
2 shared publications
- The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
- The <i>Aspergillus fumigatus maiA</i> gene contributes to cell wall homeostasis and fungal virulence
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