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Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-10-07
B
Brannon G. Broadfoot
Sourced from institutional research profiles (UAMS TRI or ARA).
Assistant Professor
Also affiliated: Arkansas Children's Hospital (2016–2026); Arkansas Children's Research Institute (2016–2017)
4 h-index
18 pubs
96 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Brannon G. Broadfoot's research has investigated the molecular mechanisms by which environmental exposures, specifically the water pollutant trichloroethylene (TCE), affect cellular processes. His work has focused on how chronic TCE exposure alters epigenetic modifications in CD4+ T cells, including changes in DNA methylation patterns. Publications from his group have demonstrated that TCE increases epigenetic drift and specifically targets the promoter regions of genes like Interferon-gamma (Ifng) in these immune cells. Further investigations have explored the enrichment of these TCE-induced DNA methylation alterations within polycomb protein binding sites in effector/memory CD4+ T cells. Broadfoot has also contributed to the medical literature through case reports and reviews on various oncological and rare genetic conditions, including intravascular large B-cell lymphoma, metastatic laryngeal neuroendocrine carcinoma, recurrent hepatocellular carcinoma, and pseudohypoaldosteronism type 1A.
Metrics
- h-index: 4
- Publications: 18
- Citations: 96
Positions
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Assistant Professor publications 2014–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Hypertrophic Lichen Sclerosus (2026)
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Photo Quiz: An infant with cough and lymphocytosis (2026)
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Photo Quiz: Persistent papules in an immunocompromised child (2026)
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958 Hypertrophic Lichen Sclerosus: A Form of “Atypical” Lichen Sclerosus in the Pathway to HPV-Independent Squamous Cell Carcinoma of the Vulva (2026)
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Navigating molecular neuropathology of CNS neoplasms for the practicing surgical pathologist (2025)
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1147 BAP1 Loss in Carcinoma ex Pleomorphic Adenoma (2025)
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NR3C2 microdeletions—an underrecognized cause of pseudohypoaldosteronism type 1A: a case report and literature review (2024)
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Intravascular Large B-Cell Lymphoma: A Diagnostic Dilemma (2021)
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Clinical and histological response to combination nivolumab and ipilimumab in metastatic renal cell carcinoma (2020)
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2218 Recurrent Hepatocellular Carcinoma From Needle Tract Seeding 13 Years Post-Transplant (2019)
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1666 A Rare Case of Colonic Malakoplakia in an Immunocompetent Man With Prior Chronic Hepatitis C Virus Infection (2019)
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Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden (2017)
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Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells (2017)
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Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells (2016)
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Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells (2016)
Collaboration Network
Top Collaborators
Kathleen M. Gilbert
Arkansas Children's Hospital
4 shared publications
In database
- Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells
- Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
- Water pollutant trichloroethylene epigenetically alters CD4+ T cells in mouse model of autoimmune disease
Craig A. Cooney
Central Arkansas Veterans Healthcare System (US)
4 shared publications
- Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells
- Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
- Water pollutant trichloroethylene epigenetically alters CD4+ T cells in mouse model of autoimmune disease
Stephen W. Erickson
Arkansas Children's Hospital (US)
4 shared publications
- Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells
- Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
- Water pollutant trichloroethylene epigenetically alters CD4+ T cells in mouse model of autoimmune disease
Sarah J. Blossom
Arkansas Children's Hospital (US)
4 shared publications
- Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells
- Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
- Water pollutant trichloroethylene epigenetically alters CD4+ T cells in mouse model of autoimmune disease
Kirk L. West
Arkansas Children's Hospital
3 shared publications
In database
- Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells
- Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
Shasha Bai
Arkansas Children's Hospital (US)
3 shared publications
- Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells
- Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
Sara C. Shalin
University of Arkansas for Medical Sciences
3 shared publications
In database
- Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden
- 958 Hypertrophic Lichen Sclerosus: A Form of “Atypical” Lichen Sclerosus in the Pathway to HPV-Independent Squamous Cell Carcinoma of the Vulva
- Hypertrophic Lichen Sclerosus
Bobby L. Boyanton
Arkansas Children's Hospital
3 shared publications
In database
- NR3C2 microdeletions—an underrecognized cause of pseudohypoaldosteronism type 1A: a case report and literature review
- Photo Quiz: Persistent papules in an immunocompromised child
- Photo Quiz: An infant with cough and lymphocytosis
Brad Reisfeld
Colorado State University (US)
2 shared publications
- Chronic Exposure to Water Pollutant Trichloroethylene Increased Epigenetic Drift in CD4 + T cells
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
Quinton D. Palmer
University of Arkansas for Medical Sciences
2 shared publications
In database
- 2218 Recurrent Hepatocellular Carcinoma From Needle Tract Seeding 13 Years Post-Transplant
- 1666 A Rare Case of Colonic Malakoplakia in an Immunocompetent Man With Prior Chronic Hepatitis C Virus Infection
Abhilash Perisetti
University of Arkansas for Medical Sciences (US)
2 shared publications
- 2218 Recurrent Hepatocellular Carcinoma From Needle Tract Seeding 13 Years Post-Transplant
- 1666 A Rare Case of Colonic Malakoplakia in an Immunocompetent Man With Prior Chronic Hepatitis C Virus Infection
Kemmian D. Johnson
University of Arkansas for Medical Sciences
2 shared publications
In database
- 2218 Recurrent Hepatocellular Carcinoma From Needle Tract Seeding 13 Years Post-Transplant
- 1666 A Rare Case of Colonic Malakoplakia in an Immunocompetent Man With Prior Chronic Hepatitis C Virus Infection
Mauricio García-Saenz-de-Sicilia
University of Arkansas for Medical Sciences
2 shared publications
In database
- 2218 Recurrent Hepatocellular Carcinoma From Needle Tract Seeding 13 Years Post-Transplant
- 1666 A Rare Case of Colonic Malakoplakia in an Immunocompetent Man With Prior Chronic Hepatitis C Virus Infection
Yadav Pandey
University of Arkansas for Medical Sciences (US)
2 shared publications
- Intravascular Large B-Cell Lymphoma: A Diagnostic Dilemma
- Clinical and histological response to combination nivolumab and ipilimumab in metastatic renal cell carcinoma
J. Stephen Nix
Alice L. Walton School of Medicine
2 shared publications
In database
- 1147 BAP1 Loss in Carcinoma ex Pleomorphic Adenoma
- Navigating molecular neuropathology of CNS neoplasms for the practicing surgical pathologist
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