Chenguang Fan
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Associate Professor
Also affiliated: University of Iowa (1999–2004); National Institutes of Health (2005); Children's National (2005–2006); Harvard University (2015–2018); University of Kansas (2026); University of Alberta (2010–2012); Iowa State University (2008–2012); Chinese Academy of Sciences (2022); Yale University (2012–2016); Institute of Electrical Engineering (2022); National Eye Institute (2005); University of Chinese Academy of Sciences (2022)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Chenguang Fan's research focuses on the molecular mechanisms of post-translational modifications, particularly lysine acetylation and aminoacylation, in biological systems. He has received two NIH grants totaling over $1 million to investigate the role of lysine aminoacylation of human metabolic enzymes and the function of lysine acetylation in human threonyl-tRNA synthetase. His work has explored the evolution of translation machinery in bacteria, enabling the incorporation of nonstandard amino acids, and the directed evolution of aminoacyl-tRNA synthetases. Fan has also studied protein packaging into bacterial microcompartments and investigated therapeutic approaches for ischemia/reperfusion injury in the liver.
His scholarly output includes 78 publications with over 4,200 citations, contributing to his h-index of 34. Fan is recognized as a high-impact, highly cited researcher and a federal grant principal investigator. He actively collaborates with researchers at the University of Arkansas at Fayetteville, including Qinglei Gan, Nour Fatema, Sara Ottinger, and Josh Sakon, with whom he has co-authored multiple publications. Fan maintains an active lab website and leads a research group.
Metrics
- h-index: 33
- Publications: 77
- Citations: 4,214
Positions
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Associate Professor 2022–presentUniversity of Arkansas Department of Chemistry and Biochemistry ORCID
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Assistant Professor 2016–presentUniversity of Arkansas Fayetteville Chemistry and Biochemistry ORCID
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Associate Research Scientist 2015–2016Yale University Molecular Biophysics and Biochemistry ORCID
Selected Publications
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Crystal structures of Escherichia coli glucokinase acetylation-mimicking variants and insights into the impact of acetylation (2026)
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Expanding the Genetic Code with Lysine Aminoacylation (2026)
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Additional file 1 of Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655 (2026)
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Additional file 1 of Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655 (2026)
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Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655 (2026)
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Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655 (2026)
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Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655 (2026)
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Crystal structures of Escherichia coli glucokinase and insights into phosphate binding (2025)
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Functional consequences of lysine acetylation of phosphofructokinase isozymes (2025)
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Orthogonal Translation for Site-Specific Installation of Post-translational Modifications (2024)
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Characterizing lysine acetylation of glucokinase (2023)
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Studying lysine acetylation of citric acid cycle enzymes by genetic code expansion (2023)
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“ Not‐so‐popular ” orthogonal pairs in genetic code expansion (2022)
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Modifications of cellulose-based biomaterials for biomedical applications (2022)
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Editorial: Engineering Nucleic Acids-Based Functional Nanomaterials, Nanodrugs, and Biosensors (2022)
Federal Grants 2 $1,012,500 total
The role of lysine acetylation of human threonyl-tRNA synthetase
Collaboration Network
Top Collaborators
- Studying the Lysine Acetylation of Malate Dehydrogenase
- Genetically Incorporating Two Distinct Post-translational Modifications into One Protein Simultaneously
- Methyl-Coenzyme M Reductase and Its Post-translational Modifications
- Orthogonal Translation for Site-Specific Installation of Post-translational Modifications
- Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli
Showing 5 of 30 shared publications
- Studying the Lysine Acetylation of Malate Dehydrogenase
- Genetically Incorporating Two Distinct Post-translational Modifications into One Protein Simultaneously
- Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli
- Recent Development of Genetic Code Expansion for Posttranslational Modification Studies
- Characterizing lysine acetylation of Escherichia coli type II citrate synthase
Showing 5 of 13 shared publications
- Studying the Lysine Acetylation of Malate Dehydrogenase
- Genetically Incorporating Two Distinct Post-translational Modifications into One Protein Simultaneously
- Genetically encoding thioacetyl‐lysine as a non‐deacetylatable analog of lysine acetylation in Escherichia coli
- Biochemical Characterization of the Lysine Acetylation of Tyrosyl‐tRNA Synthetase in Escherichia coli
- A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
Showing 5 of 6 shared publications
- Catalytic Activity, Stability, and Loading Trends of Alcohol Dehydrogenase Enzyme Encapsulated in a Metal–Organic Framework
- Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli
- Characterizing lysine acetylation of Escherichia coli type II citrate synthase
- Genome-Wide Quantification of the Effect of Gene Overexpression on Escherichia coli Growth
- Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli
- Recent Development of Genetic Code Expansion for Posttranslational Modification Studies
- Characterizing lysine acetylation of Escherichia coli type II citrate synthase
- Genome-Wide Quantification of the Effect of Gene Overexpression on Escherichia coli Growth
- Modifications of cellulose-based biomaterials for biomedical applications
- Characterizing lysine acetylation of glucokinase
- Studying lysine acetylation of citric acid cycle enzymes by genetic code expansion
- Functional consequences of lysine acetylation of phosphofructokinase isozymes
- Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655
- Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655
- Additional file 1 of Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655
- Additional file 1 of Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655
- Genetically Incorporating Two Distinct Post-translational Modifications into One Protein Simultaneously
- Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli
- Characterizing lysine acetylation of Escherichia coli type II citrate synthase
- Genome-Wide Screening of Oxidizing Agent Resistance Genes in Escherichia coli
- Genome-Wide Quantification of the Effect of Gene Overexpression on Escherichia coli Growth
- Introducing noncanonical amino acids for studying and engineering bacterial microcompartments
- The Application of Cell-Free Protein Synthesis in Genetic Code Expansion for Post-translational Modifications
- Site-Specifically Studying Lysine Acetylation of Aminoacyl-tRNA Synthetases
- A Synthetic Reporter for Probing Mistranslation in Living Cells
- Continuous directed evolution of aminoacyl-tRNA synthetases
- Expanding the genetic code of Escherichia coli with phosphotyrosine
- Studying the Lysine Acetylation of Malate Dehydrogenase
- Genetically Incorporating Two Distinct Post-translational Modifications into One Protein Simultaneously
- Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli
- Site-Specifically Studying Lysine Acetylation of Aminoacyl-tRNA Synthetases
- Site-Specifically Studying Lysine Acetylation of Aminoacyl-tRNA Synthetases
- A Synthetic Reporter for Probing Mistranslation in Living Cells
- Genome-Wide Screening of Oxidizing Agent Resistance Genes in Escherichia coli
- A Synthetic Reporter for Probing Mistranslation in Living Cells
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