Clark C. Chen Source Confirmed
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
John Brown University
faculty
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Biography and Research Information
OverviewAI-generated summary
Dr. Clark Chen is an active faculty member at John Brown University whose research aims to improve diagnosis and treatment outcomes for individuals with brain tumors. His work encompasses a range of central nervous system malignancies, including glioma, brain metastases, meningioma, and schwannoma. Chen's investigations extend to the molecular level, exploring the roles of microRNA, hypoxia, and altered metabolism in cancer progression. He also studies the potential of extracellular vesicles as therapeutic targets and diagnostic tools. Recent publications reflect his translational focus, including clinical trials evaluating oncolytic virotherapy and combined immunotherapy approaches for recurrent glioblastoma. His research also investigates the therapeutic potential of PI3Kγ inhibition to modulate the tumor microenvironment and enhance treatment response.
Metrics
- h-index: 40
- Publications: 245
- Citations: 5,281
Selected Publications
- Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT (2025) DOI
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