Dan A. Dixon

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

COM | Biochemistry & Molecular Biology

46 h-index 201 pubs 8,447 cited

Research Areas

Cancer-related molecular mechanisms research RNA and protein synthesis mechanisms Extracellular vesicles in disease Mitochondrial Function and Pathology Cancer Treatment and Pharmacology

Links

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OverviewAI-generated summary

Dan A. Dixon, Professor in Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences, studies the molecular mechanisms underlying cancer development and progression. His research group investigates how tumor-initiating stem cells interact with their microenvironment to create an immunosuppressive and pro-tumorigenic niche. A significant area of his work focuses on the role of RNA-binding proteins, such as HuR and IMP1/IGF2BP1, in posttranscriptional gene regulation within cancer cells and extracellular vesicles.

Dixon's publications detail the involvement of these proteins in stabilizing key oncogenic mRNAs like c-Myc and regulating protumorigenic factors such as YAP1 in pancreatic and colorectal cancers. His research also explores therapeutic strategies, including the investigation of the FDA-approved drug pyrvinium pamoate for its potential to inhibit pancreatic cancer cells under nutrient-depleted conditions by targeting mitochondria. His scholarship metrics include an h-index of 46, with 201 total publications and 8,447 total citations, designating him as a highly cited researcher.

Metrics

  • h-index: 46
  • Publications: 201
  • Citations: 8,447

Selected Publications

  • Post-transcriptional regulation by HuR in colorectal cancer: impacts on tumor progression and therapeutic strategies (2025) DOI
  • Suppression of stress granule formation is a vulnerability imposed by mutant p53 (2025) DOI

Grants & Funding

  • Nano-Engineered Lab-on-a-Chip for Assessing HuR-Regulated Exosomes for Cancer Monitoring and Targeted Therapy NIH/Nat. Cancer Institute - Pass Through: University of Kansas Principal Investigator
  • Nano-Engineered Lab-on-a-Chip for Assessing HuR-Regulated Exosomes for Cancer Monitoring and Targeted Therapy NIH/Nat. Cancer Institute - Pass Through: University of Kansas Principal Investigator
  • Nano-Engineered Lab-on-a-Chip for Assessing HuR-Regulated Exosomes for Cancer Monitoring and Targeted Therapy NIH/Nat. Cancer Institute - Pass Through: University of Kansas Principal Investigator

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