Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-16
D
Darshan Mehta
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Visiting Scientist
Also affiliated: United States Food and Drug Administration (2019–2025); Dwarkadas J. Sanghvi College of Engineering (2023); Sunovion (United States) (2019); The Ohio State University (2016–2018); Vion Pharmaceuticals (United States) (2019)
Faculty Researcher
7 h-index
31 pubs
289 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Darshan Mehta's research focuses on pharmacokinetic modeling and toxicological studies, particularly concerning drug transfer and exposure in pregnant individuals and newborns. He investigates the application of physiologically based pharmacokinetic (PBPK) modeling to estimate drug metabolism, absorption, distribution, metabolism, and excretion (ADME) processes in specific populations, including premature and mature newborns.
Mehta has explored the placental transfer of various drugs in pregnant rats and the pharmacokinetics of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters. His work also includes toxicokinetic and genotoxicity studies of specific compounds, such as NNK, in male Sprague Dawley rats following different exposure routes. Additionally, he has investigated the role of extracellular vesicles in biological processes, including their production and trafficking, and the evaluation of microphysiological models for studying drug transfer across the human placental barrier.
Metrics
- h-index: 7
- Publications: 31
- Citations: 289
Selected Publications
-
Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters (2025)
-
Applications of PBPK Modeling to Estimate Drug Metabolism and Related ADME Processes in Specific Populations (2025)
-
Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023)
-
Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles (2023)
-
Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking (2022)
-
In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats (2022)
-
Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking (2022)
-
Challenges in predicting the pharmacokinetics of drugs in premature and mature newborns (2021)
-
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
-
List of contributors (2020)
-
Chemical absorption and writing code for portals of entry (2020)
-
Fundamentals of physiologically based pharmacokinetic modeling (2020)
-
Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine (2020)
-
Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol (2020)
-
Ontogeny equations with probability distributions for anthropomorphic measurements in preterm and term neonates and infants for use in a PBPK model (2019)
Collaboration Network
Top Collaborators
Matthew Bryant
National Center for Toxicological Research
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats
- Evaluation of a microphysiological human placental barrier model for studying placental drug transfer
Prashant Kumar
National Center for Toxicological Research (US)
3 shared publications
- Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
John J. Bissler
University of Tennessee Health Science Center (US)
3 shared publications
- Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
Jeffrey W. Fisher
United States Food and Drug Administration (US)
2 shared publications
- In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats
- Challenges in predicting the pharmacokinetics of drugs in premature and mature newborns
Miao Li
National Center for Toxicological Research (US)
2 shared publications
- Evaluation of a microphysiological human placental barrier model for studying placental drug transfer
- Challenges in predicting the pharmacokinetics of drugs in premature and mature newborns
Fahad Zadjali
Sultan Qaboos University (OM)
2 shared publications
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
Ying Yao
University of Tennessee Health Science Center (US)
2 shared publications
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
Michael Köttgen
University of Freiburg (DE)
2 shared publications
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
Alexis Hofherr
University of Freiburg (DE)
2 shared publications
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
Kenneth W. Gross
Roswell Park Comprehensive Cancer Center (US)
2 shared publications
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
Noriko Nakamura
National Center for Toxicological Research
2 shared publications
In database
- In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats
- Evaluation of a microphysiological human placental barrier model for studying placental drug transfer
Mani Chidambaram
National Center for Toxicological Research
2 shared publications
In database
- In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats
- Evaluation of a microphysiological human placental barrier model for studying placental drug transfer
Kiara Fairman
National Center for Toxicological Research
2 shared publications
In database
- Applications of PBPK Modeling to Estimate Drug Metabolism and Related ADME Processes in Specific Populations
- Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters
Shu-Chieh Hu
National Center for Toxicological Research
1 shared publication
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
Estatira Sepehr
National Center for Toxicological Research (US)
1 shared publication
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
Similar Researchers
Based on overlapping research topics
Mani Chidambaram
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Maternal and Perinatal Health Interventions
Drug Transport and Resistance Mechanisms
Lindsey L. Morrison
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Maternal and Perinatal Health Interventions
Birth, Development, and Health
K.J. Harris
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Drug Transport and Resistance Mechanisms
Animal, Disease Models
Andres Aline
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Maternal and Perinatal Health Interventions
Birth, Development, and Health
Ralph E. Patton
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Maternal and Perinatal Health Interventions
Animal, Disease Models
Anshel Bright
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Drug Transport and Resistance Mechanisms
Animal, Disease Models