D
Donna L. Mendrick Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Researcher
faculty
40 h-index
102 pubs
9,023 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Donna L. Mendrick's research focuses on the development and implementation of alternative methods in toxicity testing, moving away from traditional animal models. Her work investigates the value and application of microphysiological systems (MPS), often referred to as "organs-on-chips," for studying drug-induced liver injury and other toxicological endpoints. She has explored the co-culture of human primary hepatocytes and nonparenchymal liver cells in these systems to better predict human responses to pharmaceuticals.
Mendrick has also contributed to discussions and workshops concerning the progress of U.S. federal agencies in adopting these new approach methodologies (NAMs). Her publications address the challenges and considerations in nonclinical pharmaceutical assessments and the broader goal of protecting human and animal health through predictive toxicology. She leads a research group and has a publication record of 102 papers with over 9,000 citations, reflecting a h-index of 40.
Metrics
- h-index: 40
- Publications: 102
- Citations: 9,023
Selected Publications
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Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development (2025)
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Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare (2025)
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Potential value of animal microphysiological systems (2024)
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Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods (2024)
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Gaps and challenges in nonclinical assessments of pharmaceuticals: An FDA/CDER perspective on considerations for development of new approach methodologies (2023)
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Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022)
Collaboration Network
Top Collaborators
Suzanne Fitzpatrick
Center for Food Safety and Applied Nutrition (US)
5 shared publications
- Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods
- FutureTox IV Workshop Summary: <i>Predictive Toxicology for Healthy Children</i>
- Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare
- Potential value of animal microphysiological systems
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Paul C. Brown
Center for Drug Evaluation and Research (US)
3 shared publications
- Gaps and challenges in nonclinical assessments of pharmaceuticals: An FDA/CDER perspective on considerations for development of new approach methodologies
- Potential value of animal microphysiological systems
- Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development
Nicole Kleinstreuer
National Institute of Environmental Health Sciences
2 shared publications
In database
- FutureTox IV Workshop Summary: <i>Predictive Toxicology for Healthy Children</i>
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Thomas B. Knudsen
Environmental Protection Agency (US)
2 shared publications
- Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods
- FutureTox IV Workshop Summary: <i>Predictive Toxicology for Healthy Children</i>
Lorna Ewart
Emulate (United States) (US)
2 shared publications
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare
Amy M. Avila
Center for Drug Evaluation and Research (US)
2 shared publications
- Gaps and challenges in nonclinical assessments of pharmaceuticals: An FDA/CDER perspective on considerations for development of new approach methodologies
- Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development
Kevin A. Ford
2 shared publications
- Potential value of animal microphysiological systems
- Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development
John Gordon
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Carol Clarke
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Matthew Johnson
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Emily N. Reinke
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Barnett A. Rattner
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Steve T. Hwang
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Evisabel A. Craig
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
Anna Lowit
1 shared publication
- Measuring U.S. Federal Agency progress toward implementation of alternative methods in toxicity testing
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