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Current · Arkansas
Last published
2025
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OpenAlex · ORCID
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2026-10-06
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Dayton M. Petibone
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Also affiliated: United States Food and Drug Administration (2011–2025); Wayne State University (2007–2010)
14 h-index
33 pubs
797 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Dayton M. Petibone's research investigates genotoxicity and carcinogenic outcomes. This work includes evaluating the potential value of animal microphysiological systems for drug development and assessing whether available data are sufficient to inform risk assessment for DNA-reactive drugs. Publications also explore the in vitro effects of compounds like cannabidiol and black cohosh extract on mammalian cells, examining potential genotoxic mechanisms.
Petibone's scholarship includes 33 publications, with 771 citations and an h-index of 14. Key collaborators include Donna L. Mendrick, Volodymyr Tryndyak, Nan Mei, and Mugimane G. Manjanatha, all affiliated with the National Center for Toxicological Research. Recent work has focused on considerations for animal microphysiological systems in drug development, aligning with the 3Rs principles (Replacement, Reduction, Refinement) in animal research.
Metrics
- h-index: 14
- Publications: 33
- Citations: 797
Selected Publications
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Assessing carcinogenic outcomes following short-term exposure to potentially DNA-reactive drugs: Are available data sufficient to inform risk assessment? (2025)
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Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development (2025)
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Potential value of animal microphysiological systems (2024)
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In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells (2021)
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
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Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment (2020)
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Dr. Daniel Acosta and In Vitro toxicology at the U.S. Food and Drug Administration's National Center for Toxicological Research (2019)
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Quantification of cellular associated graphene and induced surface receptor responses (2019)
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Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells (2018)
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Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes (2018)
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Fluorescence In Situ Hybridization in Genotoxicity Testing (2017)
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In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene (2017)
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p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity (2017)
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Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity (2016)
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The role of surface chemistry in the cytotoxicity profile of graphene (2016)
Collaboration Network
Top Collaborators
Suzanne M. Morris
National Center for Toxicological Research (US)
7 shared publications
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Pubertal delay in male nonhuman primates ( Macaca mulatta ) treated with methylphenidate
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
- Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines
- The genetic toxicity of methylphenidate: a review of the current literature
Showing 5 of 7 shared publications
Vasily N. Dobrovolsky
National Center for Toxicological Research
6 shared publications
In database
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
- Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines
- In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
Showing 5 of 6 shared publications
Javier R. Revollo
National Center for Toxicological Research
5 shared publications
In database
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines
- In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
- Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes
Mason G. Pearce
National Center for Toxicological Research
4 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
- Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes
Syed F. Ali
National Center for Toxicological Research
4 shared publications
In database
- Toxicity and efficacy of carbon nanotubes and graphene: the utility of carbon-based nanoparticles in nanomedicine
- The role of surface chemistry in the cytotoxicity profile of graphene
- Quantification of cellular associated graphene and induced surface receptor responses
- Dr. Daniel Acosta and In Vitro toxicology at the U.S. Food and Drug Administration's National Center for Toxicological Research
Robert H. Heflich
National Center for Toxicological Research
4 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene
- Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes
- Dr. Daniel Acosta and In Vitro toxicology at the U.S. Food and Drug Administration's National Center for Toxicological Research
Daniel A. Casciano
University of Arkansas at Little Rock (US)
4 shared publications
- Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity
- The role of surface chemistry in the cytotoxicity profile of graphene
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
- Quantification of cellular associated graphene and induced surface receptor responses
James J. Chen
National Center for Toxicological Research (US)
3 shared publications
- Pubertal delay in male nonhuman primates ( Macaca mulatta ) treated with methylphenidate
- The genetic toxicity of methylphenidate: a review of the current literature
- Evaluation of p53 genotype on gene expression in the testis, liver, and heart from male C57BL/6 mice
Alexandru S. Biris
University of Arkansas at Little Rock
3 shared publications
In database
- Toxicity and efficacy of carbon nanotubes and graphene: the utility of carbon-based nanoparticles in nanomedicine
- The role of surface chemistry in the cytotoxicity profile of graphene
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
Wei Ding
National Center for Toxicological Research (US)
3 shared publications
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
- Fluorescence In Situ Hybridization in Genotoxicity Testing
Waqar Majeed
University of Arkansas at Little Rock
3 shared publications
In database
- Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity
- The role of surface chemistry in the cytotoxicity profile of graphene
- Quantification of cellular associated graphene and induced surface receptor responses
Shawn E. Bourdo
University of Arkansas at Little Rock
3 shared publications
In database
- The role of surface chemistry in the cytotoxicity profile of graphene
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
- Quantification of cellular associated graphene and induced surface receptor responses
Zeid A. Nima
University of Arkansas at Little Rock
3 shared publications
In database
- The role of surface chemistry in the cytotoxicity profile of graphene
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
- Quantification of cellular associated graphene and induced surface receptor responses
Fumiya Watanabe
University of Arkansas at Little Rock
3 shared publications
In database
- The role of surface chemistry in the cytotoxicity profile of graphene
- p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity
- Quantification of cellular associated graphene and induced surface receptor responses
Timothy W. Robison
United States Food and Drug Administration (US)
3 shared publications
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
- Assessing carcinogenic outcomes following short-term exposure to potentially DNA-reactive drugs: Are available data sufficient to inform risk assessment?
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