Frank A. Simmen
Sourced from institutional research profiles (UAMS TRI or ARA).
Professor
Also affiliated: College of Wooster (1990); Arkansas Children's Hospital (2006–2014); Pennsylvania State University (1990–1991); Florida Department of Agriculture and Consumer Services (2001); University of California, San Francisco (2008); Baylor College of Medicine (1984–1985); Washington University in St. Louis (1989); University of Arkansas Medical Center (2008–2011); Ohio Department of Agriculture (1987–2020); Chinju National University of Education (1998); University of Florida (1989–2004); Czech Academy of Sciences, Institute of Biophysics (2016); Arkansas Cardiology (2010–2012); Institute of Biophysics and Biomedical Engineering (2015); Winthrop Rockefeller Foundation (2012–2023); Arkansas Children's Nutrition Center (2003–2010); The Ohio State University (1987–2020); University of Florida Health Science Center (1991); University of Missouri (1989); Penn State Milton S. Hershey Medical Center (1996)
Faculty Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Frank A. Simmen's research focuses on the molecular mechanisms underlying metabolic diseases and cancer, with a particular emphasis on the roles of specific transcription factors and growth factors. His work investigates how genes like Malic Enzyme 1 (ME1) and Krüppel-like Factors (KLFs) influence adiposity, hepatic steatosis, and the development of hepatocellular carcinoma (HCC) in preclinical models. Simmen's group has explored the impact of diet, such as high-fat diets, on disease progression and has examined the interplay between genetic factors and environmental influences, such as lesion genotype in endometriosis development.
His research also extends to reproductive biology, investigating the transcriptional and endocrine regulatory networks that drive parturition, as highlighted in his recent publication on myometrial SP/Krüppel-like factors. Simmen collaborates with researchers at the University of Arkansas for Medical Sciences, including Rosalia C. M. Simmen, Iad Alhallak, Maria Theresa E. Montales, and Lin-Xi Li, with whom he has co-authored multiple publications. With an h-index of 55, over 200 publications, and more than 7,600 citations, Simmen is recognized as a highly cited researcher.
Metrics
- h-index: 54
- Publications: 208
- Citations: 7,618
Selected Publications
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Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks (2025)
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Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis (2023)
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Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice (2023)
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Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet (2022)
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Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice (2021)
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Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021)
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Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism (2020)
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SUN-126 Distinct Molecular Phenotypes of Non-Diseased Breast Adipose Tissue of Pre-Menopausal Obese and Non-Obese Women May Underlie Differing Breast Cancer Risks (2020)
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Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells (2020)
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Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice (2019)
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Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice (2018)
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Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis (2018)
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Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice (2018)
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Tales from the Crypt: Malic Enzyme 1 (ME1) Links Metabolism to Intestinal Cancer (2017)
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Maternal Metabolic State and Cancer Risk: An Evolving Manifestation of Generational Impact (2016)
Collaboration Network
Top Collaborators
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
Showing 5 of 6 shared publications
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
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