Rosalia C. M. Simmen

High Impact

Researcher

UAMS

Last publication 2025 Last refreshed 2026-05-16

faculty

29 h-index 97 pubs 2,473 cited

Research Areas

Links

ORCID Lab Website

OverviewAI-generated summary

Rosalia C. M. Simmen's research investigates the molecular mechanisms underlying metabolic disorders and their association with oncogenesis and reproductive health conditions. Her work has explored the role of specific enzymes, such as Malic Enzyme 1 (ME1), in promoting adiposity, hepatic steatosis, and influencing circulating insulin and leptin levels in mouse models. Simmen has also studied Krüppel-like Factors (KLFs), focusing on KLF9 and KLF13 as transcriptional regulators involved in oncogenesis, and has demonstrated KLF9's ability to suppress hepatocellular carcinoma-promoting oxidative stress and inflammation in mice fed a high-fat diet.

Further research by Simmen has examined the interplay between diet and hormonal factors in the development of endometriosis, including a pilot study on the co-existence of diabetes and endometriosis in women and investigations into how lesion genotype modifies high-fat diet effects on endometriosis development in mice. Her publication record also includes work on the regulation of breast adipose tissue phenotype by interleukin 10 in premenopausal women and long-term studies on the heritability of serum insulin-like growth factor I concentration in beef cattle.

Simmen's scholarship metrics include an h-index of 29 and over 2,400 citations across 97 publications. She collaborates with several researchers at the University of Arkansas for Medical Sciences, including Frank A. Simmen, Charles M. Quick, Garrett L. Graham, and Maria Theresa E. Montales, with whom she has co-authored multiple publications. She maintains an active lab website and is recognized as a highly cited researcher.

Metrics

h-index: 29
Publications: 97
Citations: 2,473

Selected Publications

Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality (2026)

DOI OpenAlex
Transcriptional drivers and endocrine disorders (2025)

DOI OpenAlex
Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks (2025)

DOI OpenAlex
Endometriosis and Endometriosis-Associated Tumors (2025)

DOI OpenAlex
Heritability and Correlation Estimates for Serum Insulin-like Growth Factor I Concentration, Weight, Weight Gain, and Height in Angus Beef Cattle in a Long-Term Divergent Selection Study for Serum Insulin-like Growth Factor I (1989 to 2017) (2024)

1 citation DOI OpenAlex
Endometriosis and Endometriosis-Associated Tumors (2024)

1 citation DOI OpenAlex
Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis (2023)

15 citations DOI OpenAlex
Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice (2023)

24 citations DOI OpenAlex
A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression (2023)

9 citations DOI OpenAlex
Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet (2022)

14 citations DOI OpenAlex
Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice (2021)

8 citations DOI OpenAlex
Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021)

8 citations DOI OpenAlex
Co-Morbidity of Type 1 Diabetes Promotes Endometriosis Status-A Pilot Study (2021)

DOI OpenAlex