Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
R
Rosalia C. M. Simmen
High Impact
Emeritus
Professor Emerita
Also affiliated: Arkansas Children's Hospital (2014); Agricultural Research Service (1997); Kansas State University (1997); University of Arkansas Medical Center (2019); University of Florida (1989–2006); Roman L. Hruska U.S. Meat Animal Research Center (1997); Arkansas Children's Nutrition Center (2005–2013); Arkansas Children's Research Institute (2014); Institute of Food and Agricultural Sciences (1997); The Ohio State University (1988–1990); Nagoya University (2013); University of Missouri (1990)
29 h-index
94 pubs
2,514 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Rosalia C. M. Simmen's research focuses on the molecular mechanisms regulating gene expression in reproductive tissues, with a particular emphasis on insulin-like growth factors (IGFs) and their binding proteins. Her work has investigated the expression of IGF-I, IGF-II, and IGF binding protein-2 messenger RNAs in bovine endometrium during the estrous cycle and early pregnancy. She has also examined the cloning and uterine expression of porcine IGF-I, as well as the hormonal regulation of IGF gene expression in the pig uterus. Investigations into the role of Krüppel-like Factor 9 (KLF9) have explored its interaction with progesterone receptor isoforms and its coregulation of endometrial stromal cells, with implications for endometriosis pathogenesis.
Simmen's research extends to the study of dietary components and their impact on cancer stem-like cells. Her work includes investigating the repression of mammosphere formation in human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids. Her scholarship metrics include an h-index of 29, with 97 total publications and 2,513 total citations, designating her as a highly cited researcher. Key collaborators include Iad Alhallak, Frank A. Simmen, Charles M. Quick, and Garrett L. Graham, all from the University of Arkansas for Medical Sciences.
Metrics
- h-index: 29
- Publications: 94
- Citations: 2,514
Positions
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Professor Emerita publications 2003–2025University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality (2026)
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Transcriptional drivers and endocrine disorders (2025)
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Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks (2025)
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Endometriosis and Endometriosis-Associated Tumors (2025)
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Heritability and Correlation Estimates for Serum Insulin-like Growth Factor I Concentration, Weight, Weight Gain, and Height in Angus Beef Cattle in a Long-Term Divergent Selection Study for Serum Insulin-like Growth Factor I (1989 to 2017) (2024)
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Endometriosis and Endometriosis-Associated Tumors (2024)
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Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis (2023)
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Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice (2023)
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A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression (2023)
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Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet (2022)
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Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice (2021)
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Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021)
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Co-Morbidity of Type 1 Diabetes Promotes Endometriosis Status-A Pilot Study (2021)
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Metformin regulation of progesterone receptor isoform‑B expression in human endometrial cancer cells is glucose‑dependent (2020)
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Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism (2020)
Collaboration Network
Top Collaborators
Frank A. Simmen
University of Arkansas for Medical Sciences
55 shared publications
In database
- Selective Interactions of Krüppel-like Factor 9/Basic Transcription Element-binding Protein with Progesterone Receptor Isoforms A and B Determine Transcriptional Activity of Progesterone-responsive Genes in Endometrial Epithelial Cells
- Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis
- Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Krüppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene
- Soy Protein Isolate and Protection Against Cancer
- Kruppel-Like Factor 9 Is a Negative Regulator of Ligand-Dependent Estrogen Receptor α Signaling in Ishikawa Endometrial Adenocarcinoma Cells
Showing 5 of 55 shared publications
John Mark P. Pabona
Arkansas Children's Nutrition Center (US)
19 shared publications
- Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis
- High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status
- The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein
- Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
- Functional Differentiation of Uterine Stromal Cells Involves Cross-Regulation between Bone Morphogenetic Protein 2 and Kruppel-Like Factor (KLF) Family Members KLF9 and KLF13
Showing 5 of 19 shared publications
Maria Theresa E. Montales
University of Arkansas for Medical Sciences
14 shared publications
In database
- Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells
- The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein
- Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells
- The Krüppel-like factors in female reproductive system pathologies
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
Showing 5 of 14 shared publications
Michael C. Velarde
University of the Philippines Diliman (PH)
14 shared publications
- Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis
- The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
- Kruppel-Like Factor 9 Is a Negative Regulator of Ligand-Dependent Estrogen Receptor α Signaling in Ishikawa Endometrial Adenocarcinoma Cells
- Inhibition of NMU-induced mammary tumorigenesis by dietary soy
- Delayed Parturition and Altered Myometrial Progesterone Receptor Isoform A Expression in Mice Null for Krüppel-Like Factor 91
Showing 5 of 14 shared publications
Omar M. Rahal
Arkansas Children's Nutrition Center (US)
13 shared publications
- Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells
- The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein
- Paracrine-Acting Adiponectin Promotes Mammary Epithelial Differentiation and Synergizes with Genistein to Enhance Transcriptional Response to Estrogen Receptor β Signaling
- In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats
- Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer—preventive actions of dietary factors
Showing 5 of 13 shared publications
Iad Alhallak
University of Arkansas for Medical Sciences
12 shared publications
In database
- Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis
Showing 5 of 12 shared publications
Melissa E. Heard
University of Arkansas for Medical Sciences (US)
10 shared publications
- Krüppel-Like Factor 9 Deficiency in Uterine Endometrial Cells Promotes Ectopic Lesion Establishment Associated With Activated Notch and Hedgehog Signaling in a Mouse Model of Endometriosis
- High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status
- The Krüppel-like factors in female reproductive system pathologies
- Krüppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen1
- The Reproductive Phenotype of Mice Null for Transcription Factor Krüppel-Like Factor 13 Suggests Compensatory Function of Family Member Krüppel-Like Factor 9 in the Peri-Implantation Uterus1
Showing 5 of 10 shared publications
Renea R. Eason
Arkansas Children's Nutrition Center (US)
9 shared publications
- Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Krüppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene
- The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
- Inhibition of NMU-induced mammary tumorigenesis by dietary soy
- Null Mutation of Kruppel-Like Factor9/Basic Transcription Element Binding Protein-1 Alters Peri-Implantation Uterine Development in Mice1
- Progesterone Receptor Transactivation of the Secretory Leukocyte Protease Inhibitor Gene in Ishikawa Endometrial Epithelial Cells Involves Recruitment of Krüppel-Like Factor 9/Basic Transcription Element Binding Protein-1
Showing 5 of 9 shared publications
Charles Matthew Quick
Winthrop Rockefeller Foundation
9 shared publications
In database
- Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
- Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis
- Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
- Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus
- A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
Showing 5 of 9 shared publications
Ahmed Al‐Dwairi
University of Arkansas for Medical Sciences (US)
8 shared publications
- Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
- Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
- Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer
Showing 5 of 8 shared publications
Thomas M. Badger
Arkansas Children's Nutrition Center
8 shared publications
In database
- Soy Protein Isolate and Protection Against Cancer
- The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
- Inhibition of NMU-induced mammary tumorigenesis by dietary soy
- Dietary Exposure to Whey Proteins Alters Rat Mammary Gland Proliferation, Apoptosis, and Gene Expression during Postnatal Development
- Uterine phenotype of young adult rats exposed to dietary soy or genistein during development
Showing 5 of 8 shared publications
Sara R. Till
Arkansas Children's Nutrition Center (US)
8 shared publications
- Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Krüppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene
- The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
- Inhibition of NMU-induced mammary tumorigenesis by dietary soy
- Dietary Exposure to Whey Proteins Alters Rat Mammary Gland Proliferation, Apoptosis, and Gene Expression during Postnatal Development
- Uterine phenotype of young adult rats exposed to dietary soy or genistein during development
Showing 5 of 8 shared publications
Adam R. Brown
University of Arkansas for Medical Sciences (US)
7 shared publications
- The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers
- Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer
- Abstract 1969: The potential tumor-suppressive role of Kruppel-like factor 9 in colorectal cancer.
Showing 5 of 7 shared publications
Yan Geng
Arkansas Children's Nutrition Center (US)
7 shared publications
- The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
- Inhibition of NMU-induced mammary tumorigenesis by dietary soy
- Dietary Exposure to Whey Proteins Alters Rat Mammary Gland Proliferation, Apoptosis, and Gene Expression during Postnatal Development
- Uterine phenotype of young adult rats exposed to dietary soy or genistein during development
- Tp53-Associated Growth Arrest and DNA Damage Repair Gene Expression Is Attenuated in Mammary Epithelial Cells of Rats Fed Whey Proteins
Showing 5 of 7 shared publications
Bhuvanesh Dave
Houston Methodist (US)
5 shared publications
- The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
- The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein
- Tp53-Associated Growth Arrest and DNA Damage Repair Gene Expression Is Attenuated in Mammary Epithelial Cells of Rats Fed Whey Proteins
- Enhanced Mammary Progesterone Receptor-A Isoform Activity in the Promotion of Mammary Tumor Progression by Dietary Soy in Rats
- Soy peptide lunasin induces PTEN‐mediated apoptosis in human breast cancer cells
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