Harrison Brown

High Impact

Researcher

UAMS

Also affiliated: Pasadena City College (1957); California Institute of Technology (1953–1975); Argonne National Laboratory (1948–1950); University of British Columbia Hospital (2017); Children's Medical Center (2022–2025); National Academy of Sciences (1959–1974); National Academy of Engineering (1959); University of British Columbia (2017); Johns Hopkins University (1941–1980); Hess (United States) (1980); Brookhaven National Laboratory (1955); Johns Hopkins University Applied Physics Laboratory (1939); University of Chicago (1947–1951); East–West Center (1978–1983); Canadian Bulletin of Medical History (1986); Resource Development Institute (1981); Institute of Geochemistry (1956–1958); Care Resource (1981); Japan Society (1957); National Health Council (1959); University of Virginia (1963); Carnegie Mellon University (1972); The University of Texas Southwestern Medical Center (2022–2025); University of California, Berkeley (1938)

Faculty Researcher

26 h-index 149 pubs 2,950 cited

Research Areas

Biomedical Subjects

Links

Lab Website

OverviewAI-generated summary

Harrison Brown's research focuses on the metabolic pathways involved in purine synthesis and cellular energy production, with a particular emphasis on mitochondrial function and its role in cancer and oxidative metabolism. His work has investigated the de novo and salvage purine synthesis pathways across various tissues and tumors, contributing to an understanding of how cancer cells obtain essential building blocks. Brown has also explored the structural and functional aspects of key enzymes, such as NADK2, with publications detailing its dimeric organization and active site regulation.

His recent research highlights the critical role of mitochondrial NADPH in fueling fatty acid synthesis and lipoylation, processes essential for powering oxidative metabolism. This work connects fundamental metabolic processes to broader cellular functions, including energy production. Brown's research network includes collaborations with Benjamin M. Stronach and Bryce Wall at the University of Arkansas for Medical Sciences. With a publication record of 149 papers and an h-index of 26, he is recognized as a highly cited researcher.

Metrics

h-index: 26
Publications: 149
Citations: 2,950

Selected Publications

Interprosthetic Femur Fractures: A Multicenter Retrospective Study (2025)

Journal of Orthopaedic Trauma 2 citations DOI OpenAlex
Use of 1 mm Cerclage Cables in Surgical Treatment of Periprosthetic Femur Fractures (2024)

Geriatric Orthopaedic Surgery & Rehabilitation DOI OpenAlex