E
Eleanor R. Schrems Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
faculty
9 h-index
31 pubs
185 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Eleanor R. Schrems' research focuses on the physiological and molecular mechanisms underlying cancer cachexia, particularly in skeletal muscle. Her work investigates how cancer impacts muscle mass, function, and metabolic processes, with a notable emphasis on sex-dependent differences in these responses. Schrems has examined the temporal development of cachexia, identifying biphasic transcriptional disruptions in female skeletal muscle that differ from males. Her publications also explore the role of specific molecular factors, such as microRNA-16, in muscle insulin sensitivity and contractile function, again highlighting sex-specific effects. Additionally, her research has delved into the development of skeletal muscle fibrosis in cachectic models and the potential of antioxidant interventions to attenuate muscle wasting and improve contractility. Collaborations with Tyrone A. Washington, Francielly Morena da Silva, Ana Regina Cabrera, and Nicholas P. Greene at the University of Arkansas at Fayetteville have contributed to her publication record.
Metrics
- h-index: 9
- Publications: 31
- Citations: 185
Selected Publications
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Evaluation of Biological Sex in the Pathophysiology of Recovery from Volumetric Muscle Loss with Integrated Regenerative and Rehabilitative Therapies (2025)
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Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia (2025)
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Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity (2025)
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Aerobic Exercise Training Does Not Attenuate Fibrosis In Autologous Repaired Vml-injured Skeletal Muscle (2025)
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Skeletal Muscle Damage and Inflammation (2025)
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Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
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Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice (2025)
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Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025)
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Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024)
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Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice (2024)
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Supplemental table 6 (2023)
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Supplemental table 1 (2023)
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Supplemental table 3 (2023)
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Supplemental table 2 (2023)
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Supplemental table 4 (2023)
Collaboration Network
Top Collaborators
Tyrone A. Washington
University of Arkansas at Fayetteville
31 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 31 shared publications
Nicholas P. Greene
University of Arkansas at Fayetteville
29 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 29 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
25 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
Showing 5 of 25 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
24 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
Showing 5 of 24 shared publications
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
18 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 18 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
16 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males
Showing 5 of 16 shared publications
Seongkyun Lim
University of Arkansas at Fayetteville
15 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 15 shared publications
Stavroula Tsitkanou
University of Arkansas at Fayetteville
11 shared publications
In database
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice
- Supplemental table 5
Showing 5 of 11 shared publications
Landen W. Saling
University of Arkansas at Fayetteville
9 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Growth Differentiation Factor 5 Is A Paracrine Regulator In Sarcopenic Obesity
Showing 5 of 9 shared publications
J. William Deaver
University of Arkansas at Fayetteville (US)
7 shared publications
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Males, But Not Females, Demonstrate Mitochondrial Dysfunction In The C26 Model Of Cancer Cachexia
Showing 5 of 7 shared publications
Richard Perry
Colorado State University (US)
6 shared publications
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Leucine Supplementation Exacerbates Morbidity in Male but Not Female Mice with Colorectal Cancer-Induced Cachexia
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Showing 5 of 6 shared publications
Wesley S. Haynie
University of Arkansas at Fayetteville
5 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Leucine Supplementation Exacerbates Morbidity in Male but Not Female Mice with Colorectal Cancer-Induced Cachexia
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Ronald G. Jones
University of Arkansas at Fayetteville
5 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males
- Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia
- Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity
Lemuel A. Brown
University of Arkansas at Fayetteville
4 shared publications
In database
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Jacob L. Brown
University of Arkansas at Fayetteville (US)
4 shared publications
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
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