Lu Huang
Federal Grant PI
High Impact
Assistant Professor
faculty
Microbiology & Immunology, College of Medicine
43 h-index
180 pubs
6,201 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Lu Huang's research focuses on understanding host-pathogen interactions, particularly in the context of tuberculosis infection, and investigating cellular signaling pathways that regulate metabolism. As a Principal Investigator at the University of Arkansas for Medical Sciences, Huang has received significant funding from the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases for projects examining macrophage metabolism in diabetes and tuberculosis comorbidity, the role of macrophage subsets in tuberculosis lesion biology, and the ontogeny and metabolism of lung alveolar macrophages in tuberculosis. These grants total over $1.3 million.
Huang's work utilizes advanced techniques, including single-cell analysis and lattice light sheet microscopy, to investigate complex biological processes. Publications from Huang's group have explored single-cell analysis of *M. tuberculosis* and macrophage lineages in the lung, PI3K signaling's role in metabolic reprogramming, and the structural dynamics of cellular processes like macropinosome formation. Collaborations within the University of Arkansas for Medical Sciences, including with Lin-Xi Li, J. Tucker Andrews, Shengyu Mu, and Zijing Zhang, have resulted in multiple shared publications, reflecting a cohesive research network.
With a h-index of 43 and over 6,000 citations across 180 publications, Huang is recognized as a highly cited researcher. The research portfolio spans fundamental biology, host-pathogen dynamics, and cellular metabolism, with a strong emphasis on immune cell function and its implications for infectious disease and metabolic health.
Metrics
- h-index: 43
- Publications: 180
- Citations: 6,201
Selected Publications
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Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics (2025)
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Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer (2024)
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Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis (2024)
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SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome (2024)
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BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia (2024)
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Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection (2022)
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Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung (2021)
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Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology (2021)
Federal Grants 3 $1,377,213 total
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Aug 2025 - Jul 2027
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Aug 2024 - Jul 2029
Ontogeny and metabolism of lung alveolar macrophages in tuberculosis
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Aug 2023 - Jul 2026
Macrophage metabolism in diabetes and tuberculosis comorbidity
Grants & Funding
- ECU sub to UAMS NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: East Carolina University Principal Investigator
- Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Macrophage metabolism in diabetes and tuberculosis comorbidity NIH/National Institutes of Health Principal Investigator
- Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract US Department of Agriculture - Pass Through: University of Arkansas at Pine Bluff Principal Investigator
- Ontogeny and metabolism of lung alveolar macrophages in tuberculosis NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Deciphering trained immuity in lung resident macrophages to combat tuberculosis American Lung Association Principal Investigator
Collaboration Network
Top Collaborators
Jason G. Kerkvliet
South Dakota State University (US)
5 shared publications
- The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy
- Mannose receptor (MRC1) mediates uptake of dextran by bone marrow–derived macrophages
- Author Correction: The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy
- The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes
- Mannose receptor (MRC1) mediates uptake of dextran in macrophages via receptor-mediated endocytosis
Adam D. Hoppe
South Dakota State University (US)
5 shared publications
- The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy
- Mannose receptor (MRC1) mediates uptake of dextran by bone marrow–derived macrophages
- Author Correction: The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy
- The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes
- Mannose receptor (MRC1) mediates uptake of dextran in macrophages via receptor-mediated endocytosis
Natalie W. Thiex
South Dakota State University (US)
5 shared publications
- The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy
- Mannose receptor (MRC1) mediates uptake of dextran by bone marrow–derived macrophages
- Author Correction: The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy
- The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes
- Mannose receptor (MRC1) mediates uptake of dextran in macrophages via receptor-mediated endocytosis
Lin‐Xi Li
University of Arkansas for Medical Sciences
4 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
J. Tucker Andrews
University of Arkansas for Medical Sciences
4 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
Bo Liu
Army Medical University (CN)
4 shared publications
- TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis
- Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid
- Long-term exposure to low levels of okadaic acid accelerates cell cycle progression in colonic epithelial cells via p53 and Jak/Stat3 signaling pathways
- TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3
Qiao‐Nan Guo
Xinqiao Hospital (CN)
4 shared publications
- TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis
- Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid
- Long-term exposure to low levels of okadaic acid accelerates cell cycle progression in colonic epithelial cells via p53 and Jak/Stat3 signaling pathways
- TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3
Haiying Liu
Jiangnan University (CN)
3 shared publications
- A colorimetric gas-sensitive array sensor using filter paper for the analysis of fish freshness
- Identification of Adulterated Extra Virgin Olive Oil by Colorimetric Sensor Array
- Detection of the Inoculated Fermentation Process of Apo Pickle Based on a Colorimetric Sensor Array Method
Weilei Yao
Huazhong Agricultural University (CN)
3 shared publications
- RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells
- Garcinol Promotes the Formation of Slow-Twitch Muscle Fibers by Inhibiting p300-Dependent Acetylation of PGC-1α
- Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells.
Zhengxi Bao
Huazhong Agricultural University (CN)
3 shared publications
- RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells
- Garcinol Promotes the Formation of Slow-Twitch Muscle Fibers by Inhibiting p300-Dependent Acetylation of PGC-1α
- Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells.
Shu Wen
Huazhong Agricultural University (CN)
3 shared publications
- RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells
- Garcinol Promotes the Formation of Slow-Twitch Muscle Fibers by Inhibiting p300-Dependent Acetylation of PGC-1α
- Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells.
Feiruo Huang
Huazhong Agricultural University (CN)
3 shared publications
- RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells
- Garcinol Promotes the Formation of Slow-Twitch Muscle Fibers by Inhibiting p300-Dependent Acetylation of PGC-1α
- Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells.
Zuochen Du
Zunyi Medical University (CN)
3 shared publications
- Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF
- SHIP-1 regulates the differentiation and function of Tregs via inhibiting mTORC1 activity
- SHIP-1 Regulates the Differentiation and Function of Tregs via Inhibiting mTORC1 Activity
Chaohong Liu
Huazhong University of Science and Technology (CN)
3 shared publications
- Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF
- SHIP-1 regulates the differentiation and function of Tregs via inhibiting mTORC1 activity
- SHIP-1 Regulates the Differentiation and Function of Tregs via Inhibiting mTORC1 Activity
Shengyu Mu
University of Arkansas for Medical Sciences
3 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
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