Match tier
Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-10-08
S
Shengyu Mu
Sourced from institutional research profiles (UAMS TRI or ARA).
Federal Grant PI
Professor and Department Chair
Also affiliated: University of Arkansas Medical Center (2022–2025); University of Tokyo Hospital (2012); The University of Tokyo (2009–2015)
18 h-index
97 pubs
1,472 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Shengyu Mu investigates the mechanisms underlying salt-sensitive hypertension, focusing on the roles of immune cells and specific molecular pathways in the kidney. His federally funded research, supported by a $746,704 grant from the NIH/National Heart Lung and Blood Institute, examines how T cell homing to the kidney contributes to salt retention and blood pressure regulation. Mu's work has identified the Rac1 GTPase and the mineralocorticoid receptor as critical components of salt-sensitive hypertension in rodent models. He has also explored the involvement of CD8+ T cells and the Na-Cl co-transporter NCC in distal convoluted tubules, as well as the IFNγ-PDL1 pathway in promoting hypertension.
Beyond hypertension, Mu's research extends to other physiological processes. He has studied the regulation of PCSK9 secretion by the NLRP3 inflammasome via IL-1β and by blood flow patterns mediated by MyD88-dependent pro-inflammatory cytokines. Additionally, his work has investigated the impact of high-salt and high-fat diets on inflammation and fibrosis in mouse models of liver steatosis, and the acceleration of vascular calcification by fibroblast growth factor 23 in the absence of Klotho deficiency.
Mu's scholarly output includes 106 publications and an h-index of 18, with over 1,500 citations. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Yunmeng Liu, Christoph Mora, Katherine Deck, and Yunping Guo, with whom he shares numerous publications.
Metrics
- h-index: 18
- Publications: 97
- Citations: 1,472
Positions
-
University of Arkansas for Medical Sciences publications 2016–2026ORCID
-
Professor and Department Chair publications 2016–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
-
Macrophage Plasticity Drives Cardiac Dysfunction in Hypertension 2253031 (2026)
-
Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension 2259853 (2026)
-
Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation (2026)
-
Targeting Hyaluronan Signaling Overcomes Primary Effusion Lymphoma Cells Resistance to Rapamycin (2026)
-
Kidney Resident Memory CD8+ T cells drive the immortality of hypertension (2026)
-
Cytokine-mediated macrophage transition promotes early cardiac fibrosis in chronic hypertension (2026)
-
CD5L promotes efferocytosis and resolution of retinal ischemic injury (2026)
-
Nanoencapsulated gamma-oryzanol enhances fibroblast proliferation, migration, and reduces oxidative stress in H2O2-induced cellular aging model (2025)
-
IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287 (2025)
-
P2X7 Drives T-cell Activation Promoting Chronic Inflammation During High Blood Pressure 9289 (2025)
-
Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288 (2025)
-
Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension (2025)
-
Uncovering immune pathways for therapeutic targeting of hypertension (2025)
-
Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025)
-
Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025)
Federal Grants 1 $746,704 total
NIH
Contact PI
Apr 2019 - Mar 2029
T cell homing to the kidney contributes to salt retention and blood pressure regulation
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- AHA Pre-doc Fellowship Deck American Heart Association
- T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute
- Mu Lab Funding UAMS College of Medicine
- Role of Immune Cells in kidney in the Development of Salt-Sensitive Hypertension (Funded by: American Heart Association (SouthWest Affiliate))
- Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract US Department of Agriculture via University of Arkansas at Pine Bluff
- Kidney-resident memory CD8+ T cells promote hypertension and memorize salt sensitivity. NIH/Nat. Heart, Lung & Blood Institute
- Formation of CD8Trms in the kidney contributes to salt-memory of hypertension American Heart Association
- Center for Studies of Host Response to Cancer Therapy NIH
- Impact of hemodynamics on efferocytosis in endothelial cells NIH/Nat. Heart, Lung & Blood Institute
Collaboration Network
Top Collaborators
Christoph Mora
University of Arkansas for Medical Sciences
22 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- Mitochondrial proton leak in cardiac aging
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
Showing 5 of 22 shared publications
Katherine Deck
University of Arkansas for Medical Sciences
21 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- uEVs: A Potential Tool for Examining Renal Epithelial Cells
Showing 5 of 21 shared publications
Yunmeng Liu
University of Arkansas for Medical Sciences
20 shared publications
In database
- CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition
- KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
- The link between immunity and hypertension in the kidney and heart
Showing 5 of 20 shared publications
Lance Benson
University of Arkansas for Medical Sciences (US)
16 shared publications
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- Interferon gamma in the pathogenesis of hypertension − recent insights
- Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development
Showing 5 of 16 shared publications
Tonya Rafferty
University of Arkansas for Medical Sciences
14 shared publications
In database
- CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Abstract P200: Immune memory contributes to chronic hypertension recurrence
- Uncovering immune pathways for therapeutic targeting of hypertension
- Abstract 092: Novel Mechanism of Salt-sensitive Hypertension: CD8 + T Cells Stimulate Sodium Chloride Co-transporter NCC in Kidney
Showing 5 of 14 shared publications
Nancy J. Rusch
University of Arkansas for Medical Sciences
12 shared publications
In database
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Showing 5 of 12 shared publications
Yunping Guo
University of Arkansas for Medical Sciences
12 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- The link between immunity and hypertension in the kidney and heart
- The IFNγ‐PDL1 Pathway Enhances the Interaction Between CD8 + T Cells and Distal Convoluted Tubules to Promote Salt‐Sensitive Hypertension
- Abstract P200: Immune memory contributes to chronic hypertension recurrence
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
Showing 5 of 12 shared publications
Shuoqiu Deng
University of Arkansas for Medical Sciences
12 shared publications
In database
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Uncovering immune pathways for therapeutic targeting of hypertension
- Establishment of resident memory T cells anchors hypertension in the kidney
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
- Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension
Showing 5 of 12 shared publications
Pamela Rogers
University of Arkansas for Medical Sciences
8 shared publications
In database
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
- Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension
- Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288
- IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287
- Cytokine-mediated macrophage transition promotes early cardiac fibrosis in chronic hypertension
Showing 5 of 8 shared publications
Yunmeng Liu
University of Arkansas for Medical Sciences
7 shared publications
In database
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Uncovering immune pathways for therapeutic targeting of hypertension
- O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION
- Establishment of resident memory T cells anchors hypertension in the kidney
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
Showing 5 of 7 shared publications
Amanda J. Stolarz
University of Arkansas for Medical Sciences
6 shared publications
In database
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
- Contribution of the Renal Lymphatic Circulation to the Development of Salt‐Sensitive Hypertension
Showing 5 of 6 shared publications
Zhiqiang Qin
Winthrop Rockefeller Foundation
5 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target
- Echinomycin as a promising therapeutic agent against KSHV-related malignancies
- Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients
- Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis
Sung W. Rhee
Kaiser Permanente
4 shared publications
In database
- CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Abstract 092: Novel Mechanism of Salt-sensitive Hypertension: CD8 + T Cells Stimulate Sodium Chloride Co-transporter NCC in Kidney
- Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats
Zufeng Ding
University of Arkansas for Medical Sciences (US)
4 shared publications
- NLRP3 inflammasome via IL-1β regulates PCSK9 secretion
- Blood flow patterns regulate PCSK9 secretion via MyD88-mediated pro-inflammatory cytokines
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- NLRP3 inflammasome via IL-1β regulates PCSK9 secretion: Erratum
Jungang Chen
Winthrop Rockefeller Foundation (US)
4 shared publications
- Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target
- Echinomycin as a promising therapeutic agent against KSHV-related malignancies
- Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients
- Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis
Similar Researchers
Based on overlapping research topics
Nora Gibbons
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Disease Models, Animal
Receptor Mechanisms and Signaling
Yunping Guo
University of Arkansas for Medical Sciences
Blood Pressure and Hypertension Studies
Immune Response and Inflammation
Disease Models, Animal
Nathaniel L. Harris
University of Arkansas at Fayetteville
Immune Response and Inflammation
Disease Models, Animal
Receptor Mechanisms and Signaling
Madison K. McGraw
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Disease Models, Animal
Receptor Mechanisms and Signaling
Marie Burdine
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Disease Models, Animal
Receptor Mechanisms and Signaling
Bailu Peng
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Disease Models, Animal
Receptor Mechanisms and Signaling