Shengyu Mu
Sourced from institutional research profiles (UAMS TRI or ARA).
Researcher
Also affiliated: Nanjing University of Chinese Medicine (2025); North China University of Science and Technology (2025); Tokyo University of Technology (2015); Bunkyo University (2011); Eli Lilly (United States) (2004–2005); Princeton University (2023); Smith College (2025); University of Arkansas Medical Center (2023); Nanjing Traditional Chinese Medicine Hospital (2025); Shandong Academy of Forestry (2025); Nanjing Drum Tower Hospital (2025); Maine Farmland Trust (2024); University of Applied Management Studies (2025); Winthrop Rockefeller Foundation (2020); Arkansas Department of Agriculture (2025); The University of Tokyo (2009–2015)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Shengyu Mu's research focuses on the intersection of immunology, cardiovascular function, and disease mechanisms, with a particular emphasis on hypertension and related physiological processes. His work investigates the role of specific immune pathways, such as the IFNγ-PDL1 pathway, in the development and progression of hypertension, exploring how immune cell interactions contribute to the condition. Mu also studies the impact of pharmacological interventions and natural compounds on cardiovascular health, examining how agents like eplerenone and blueberry polyphenols can attenuate detrimental processes such as fibrosis, oxidative stress, and inflammatory signaling.
Further research by Mu delves into mechanisms of drug-induced complications, including lymphedema and lymphostasis, and explores potential therapeutic strategies. His investigations utilize various animal models, including mice and rats, to understand disease pathogenesis and evaluate treatment efficacy. Mu's scholarship metrics include an h-index of 18, 112 total publications, and 1,465 total citations. He has received federal funding, including a $746,704 grant from the NIH/National Heart Lung and Blood Institute, for research on T cell homing to the kidney and its contribution to salt retention and blood pressure regulation. Mu actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Yunmeng Liu, Christoph Mora, Katherine Deck, and Yunping Guo.
Metrics
- h-index: 18
- Publications: 114
- Citations: 1,486
Selected Publications
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Macrophage Plasticity Drives Cardiac Dysfunction in Hypertension 2253031 (2026)
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Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension 2259853 (2026)
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Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation (2026)
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Targeting Hyaluronan Signaling Overcomes Primary Effusion Lymphoma Cells Resistance to Rapamycin (2026)
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Kidney Resident Memory CD8+ T cells drive the immortality of hypertension (2026)
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Cytokine-mediated macrophage transition promotes early cardiac fibrosis in chronic hypertension (2026)
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CD5L promotes efferocytosis and resolution of retinal ischemic injury (2026)
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Nanoencapsulated gamma-oryzanol enhances fibroblast proliferation, migration, and reduces oxidative stress in H2O2-induced cellular aging model (2025)
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IL-10 Drives Macrophage to Myofibroblast Transition Promoting Chronic Fibrosis in the Failing Heart 9287 (2025)
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P2X7 Drives T-cell Activation Promoting Chronic Inflammation During High Blood Pressure 9289 (2025)
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Kidney resident-memory CD8+ T cells drive chronic high blood pressure 9288 (2025)
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Kidney Memory for Salt Sensitivity Resides in T Cells Driving Chronic Hypertension (2025)
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Uncovering immune pathways for therapeutic targeting of hypertension (2025)
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Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025)
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Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025)
Federal Grants 1 $746,704 total
T cell homing to the kidney contributes to salt retention and blood pressure regulation
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- AHA Pre-doc Fellowship Deck American Heart Association
- T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute
- Mu Lab Funding UAMS College of Medicine
- Role of Immune Cells in kidney in the Development of Salt-Sensitive Hypertension (Funded by: American Heart Association (SouthWest Affiliate))
- Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract US Department of Agriculture via University of Arkansas at Pine Bluff
- Kidney-resident memory CD8+ T cells promote hypertension and memorize salt sensitivity. NIH/Nat. Heart, Lung & Blood Institute
- Formation of CD8Trms in the kidney contributes to salt-memory of hypertension American Heart Association
- Center for Studies of Host Response to Cancer Therapy NIH
- Impact of hemodynamics on efferocytosis in endothelial cells NIH/Nat. Heart, Lung & Blood Institute
Collaboration Network
Top Collaborators
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- uEVs: A Potential Tool for Examining Renal Epithelial Cells
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
- Macrophage to Myofibroblast Transition in Diastolic Dysfunction Development
Showing 5 of 16 shared publications
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- Mitochondrial proton leak in cardiac aging
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
- Macrophage to Myofibroblast Transition in Diastolic Dysfunction Development
Showing 5 of 16 shared publications
- IFN-γ Contributes to the Immune Mechanisms of Hypertension
- The link between immunity and hypertension in the kidney and heart
- Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development
- Interferon gamma in the pathogenesis of hypertension − recent insights
- Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death
Showing 5 of 15 shared publications
- Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition
- The link between immunity and hypertension in the kidney and heart
- The IFNγ‐PDL1 Pathway Enhances the Interaction Between CD8 <sup>+</sup> T Cells and Distal Convoluted Tubules to Promote Salt‐Sensitive Hypertension
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
- Macrophage to Myofibroblast Transition in Diastolic Dysfunction Development
Showing 5 of 11 shared publications
- The link between immunity and hypertension in the kidney and heart
- The IFNγ‐PDL1 Pathway Enhances the Interaction Between CD8 <sup>+</sup> T Cells and Distal Convoluted Tubules to Promote Salt‐Sensitive Hypertension
- S-40-5: ROLE OF INTERFERON GAMMA IN T CELL MEDIATED SALT-RETENTION IN THE KIDNEY AND PROGRESSION OF HYPERTENSION
- Macrophage to Myofibroblast Transition in Diastolic Dysfunction Development
- Macrophage to Myofibroblast Transition Promotes Hypertension-Induced Cardiac Diastolic Dysfunction
Showing 5 of 10 shared publications
- P227 MACROPHAGE TO MYOFIBROBLAST TRANSITION IN THE DEVELOPMENT OF DIASTOLIC DYSFUNCTION
- Abstract P200: Immune memory contributes to chronic hypertension recurrence
- T Cells Drive Kidney Memory for Hypertension
- Establishment of resident memory T cells anchors hypertension in the kidney
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
Showing 5 of 7 shared publications
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Mitochondrial proton leak in cardiac aging
Showing 5 of 6 shared publications
- O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION
- Establishment of resident memory T cells anchors hypertension in the kidney
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Uncovering immune pathways for therapeutic targeting of hypertension
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats
- Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target
- Echinomycin as a promising therapeutic agent against KSHV-related malignancies
- Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients
- Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis
- Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target
- Echinomycin as a promising therapeutic agent against KSHV-related malignancies
- Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients
- Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis
- Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target
- Echinomycin as a promising therapeutic agent against KSHV-related malignancies
- Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients
- Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis
- Establishment of resident memory T cells anchors hypertension in the kidney
- Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction
- Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
- Uncovering immune pathways for therapeutic targeting of hypertension
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
- Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats
- Echinomycin as a promising therapeutic agent against KSHV-related malignancies
- Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients
- Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis
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