Shengyu Mu Institution-verified

Sourced from institutional research profiles (UAMS TRI or ARA).

Federal Grant PI

Researcher

UAMS

Last publication 2026 Last refreshed 2026-05-23

faculty

17 h-index 102 pubs 1,444 cited

Research Areas

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OverviewAI-generated summary

Shengyu Mu's research investigates the complex interplay between immunity, metabolism, and cardiovascular health, with a particular focus on hypertension and related conditions. His work has explored the role of specific immune pathways, such as the IFNγ-PDL1 pathway, in promoting interactions that contribute to hypertension. Mu has also examined the impact of certain compounds, like blueberry polyphenols, on oxidative stress and inflammatory signaling in human aortic endothelial cells, suggesting potential dietary interventions for cardiovascular health.

Further investigations by Mu delve into the mechanisms underlying organ damage and therapeutic interventions. This includes studying how drugs like eplerenone can attenuate fibrosis in kidneys affected by unilateral ureteral obstruction in rats by modulating macrophage behavior. He has also researched the prevention of drug-induced lymphostasis in rat mesenteric circulation using dantrolene. Mu's scholarship also extends to understanding the immune mechanisms of hypertension, linking immunity to kidney and heart health. His published work includes studies on disease models in animals, with a focus on mice and rats, and also considers human subjects. Mu has authored 99 publications, accumulating 1,419 citations, and holds an h-index of 17. He is a principal investigator on a $761,943 NIH/NHLBI grant studying T-cell homing to the kidney and its contribution to salt retention and blood pressure regulation. Mu collaborates with several researchers at the University of Arkansas for Medical Sciences, including Christoph Mora, Katherine Deck, Yunping Guo, and Tonya Rafferty.

Metrics

h-index: 17
Publications: 102
Citations: 1,444

Selected Publications

Uncovering immune pathways for therapeutic targeting of hypertension (2025)

DOI OpenAlex
Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025)

DOI OpenAlex
Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025)

DOI OpenAlex
Establishment of resident memory T cells anchors hypertension in the kidney (2025)

DOI OpenAlex
Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats (2024)

DOI OpenAlex
T Cells Drive Kidney Memory for Hypertension (2024)

DOI OpenAlex
Abstract P200: Immune memory contributes to chronic hypertension recurrence (2024)

DOI OpenAlex
Abstract P335: An innate immune component in hypertension-induced cardiac dysfunction Christoph Mora, Katherine Deck, Yunmeng Liu, Lance Benson, Tonya Rafferty, & Shengyu Mu (2024)

DOI OpenAlex
P227 MACROPHAGE TO MYOFIBROBLAST TRANSITION IN THE DEVELOPMENT OF DIASTOLIC DYSFUNCTION (2024)

DOI OpenAlex
O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION (2024)

DOI OpenAlex
Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)

14 citations DOI OpenAlex
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis (2024)

28 citations DOI OpenAlex
Kidney resident memory CD8 T cells mediate recurrence of salt-sensitive hypertension (2024)

DOI OpenAlex
Macrophage to Myofibroblast Transition Promotes Hypertension-Induced Cardiac Diastolic Dysfunction (2024)

DOI OpenAlex
Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats (2024)

7 citations DOI OpenAlex