Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
I
Irosha N. Nawarathne
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Professor and Director of Undergraduate Research
6 h-index
11 pubs
123 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Irosha N. Nawarathne's research focuses on the biocatalytic modification of natural products, particularly taxanes, to develop precursors for next-generation drugs. Her work involves studying enzyme kinetics and substrate specificity, with recent investigations into acyltransferases that convey various acyl groups to taxane acceptors. Nawarathne has also explored the X-ray crystal structures of Escherichia coli RNA polymerase in complex with benzoxazinorifamycins. Her scholarship includes publications on generating single-stranded DNA circles and the analysis of rice bran oil for fatty acid compositions. She has collaborated with researchers from the University of Arkansas for Medical Sciences and Arkansas State University.
Metrics
- h-index: 6
- Publications: 11
- Citations: 123
Positions
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Professor and Director of Undergraduate ResearchLyon College Chemistry ORCID
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Professor and Director of Undergraduate ResearchLyon College ORCID
Selected Publications
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Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives (2026)
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Cover Feature: Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024) (2024)
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Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (2024)
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Correction to “Alkenes, Brought to You in Familiar Faces” (2022)
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Alkenes, Brought to You in Familiar Faces (2022)
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Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines (2022)
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Generating single-stranded DNA circles with minimal resources (2021)
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CoA recycling by a benzoate coenzyme A ligase in cascade reactions with aroyltransferases to biocatalyze paclitaxel analogs (2020)
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Introducing Diversity through an Organic Approach (2019)
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X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins (2013)
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Point Mutations (Q19P and N23K) Increase the Operational Solubility of a 2α-O-Benzoyltransferase that Conveys Various Acyl Groups from CoA to a Taxane Acceptor (2010)
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An N -Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificity in Vitro with Analogues of N -Dearoylpaclitaxel (2009)
Collaboration Network
Top Collaborators
Kevin D. Walker
Michigan State University (US)
5 shared publications
- An N -Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificity in Vitro with Analogues of N -Dearoylpaclitaxel
- Point Mutations (Q19P and N23K) Increase the Operational Solubility of a 2α-O-Benzoyltransferase that Conveys Various Acyl Groups from CoA to a Taxane Acceptor
- Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- CoA recycling by a benzoate coenzyme A ligase in cascade reactions with aroyltransferases to biocatalyze paclitaxel analogs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
Aimen Al‐Hilfi
Michigan State University (US)
2 shared publications
- Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
Zhen Li
Michigan State University (US)
2 shared publications
- Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
Kenneth M. Merz
Michigan State University (US)
2 shared publications
- Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs
- Cover Feature: Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024)
Vadim Molodtsov
Pennsylvania State University (US)
1 shared publication
- X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
Nathan T. Scharf
University of Michigan (US)
1 shared publication
- X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
Paul D. Kirchhoff
University of Michigan (US)
1 shared publication
- X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
Hollis D. Showalter
University of Michigan (US)
1 shared publication
- X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
George A. Garcia
University of Michigan (US)
1 shared publication
- X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
Katsuhiko Murakami
Pennsylvania State University (US)
1 shared publication
- X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
Danielle M. Nevarez
Michigan State University (US)
1 shared publication
- An N -Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificity in Vitro with Analogues of N -Dearoylpaclitaxel
Yemane A. Mengistu
Michigan State University (US)
1 shared publication
- An N -Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificity in Vitro with Analogues of N -Dearoylpaclitaxel
Sean A. Sullivan
Michigan State University (US)
1 shared publication
- CoA recycling by a benzoate coenzyme A ligase in cascade reactions with aroyltransferases to biocatalyze paclitaxel analogs
Amanda Ford
Lyon College (US)
1 shared publication
- Generating single-stranded DNA circles with minimal resources
LaShawna Miller
Lyon College (US)
1 shared publication
- Generating single-stranded DNA circles with minimal resources
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