Jack Hinson

High Impact

Researcher

UAMS primary NCTR

Also affiliated: National Institutes of Health (1974–1996); Arkansas Children's Hospital (2006–2017); University of Arizona (2003); University of South Carolina (1969); University of California, San Francisco (2009); Baylor College of Medicine (1981); Vanderbilt University (1972–1975); Medical College of Wisconsin (2009–2010); University of Arkansas Medical Center (2016); University of California San Diego (2009); National Institute of Child Health (1977); Lung Institute (1974); National Heart Lung and Blood Institute (1974–2008); PAREXEL International (United States) (2012); National Institute of Child Health (1977); Eunice Kennedy Shriver National Institute of Child Health and Human Development (1979); Institute of Molecular Biology and Biophysics (2010); National Institute of Mental Health (1996); Arkansas Department of Agriculture (2010); Health and Human Development (2HD) Research Network (1977); Institute of Pharmacology (2007–2009); The University of Texas Southwestern Medical Center (2009)

Faculty Researcher

51 h-index 369 pubs 9,372 cited

Research Areas

Biomedical Subjects

Links

Research Group

OverviewAI-generated summary

Jack Hinson's research focuses on the metabolic pathways and mechanisms of drug-induced liver injury, particularly involving acetaminophen. He investigates the role of reactive intermediates and oxidative stress in the pathogenesis of this condition. His work also explores the function of various transporters and enzymes, such as organic cation transporters (OCTs) and catechol-O-methyl transferase (COMT), in xenobiotic metabolism. Hinson's publications contribute to understanding the fundamental processes of drug metabolism, including first-pass effects and conjugation reactions, which are critical for drug discovery and development.

With a substantial publication record and a high citation count, Hinson is recognized as a highly cited researcher. He leads a research group at the University of Arkansas for Medical Sciences, where he contributes to the advancement of knowledge in toxicology and pharmacology. His research has implications for understanding how the body processes drugs and the potential for toxicity, particularly in the liver.

Metrics

h-index: 51
Publications: 369
Citations: 9,372

Selected Publications

Development of clinical assays for determination of acetaminophen protein adducts (2024)

Elsevier eBooks 1 citation DOI OpenAlex
15 Amino Acid Conjugation (2022)

IUPAC Standards Online 1 citation DOI OpenAlex
158 Organic Cation Transporters (Octs) (2022)

IUPAC Standards Online 1 citation DOI OpenAlex
36 Catechol-O-Methyl Transferase (Comt) (2022)

IUPAC Standards Online 1 citation DOI OpenAlex
191 Reactive Intermediates (2022)

IUPAC Standards Online 4 citations DOI OpenAlex
45 Cysteine-S-Conjugate Β-Lyase (C-S Lyase) (2022)

IUPAC Standards Online DOI OpenAlex
228 Ultra-Rapid Metabolizer (2022)

IUPAC Standards Online DOI OpenAlex
190 Reaction Phenotyping (2022)

IUPAC Standards Online DOI OpenAlex
28 Bioequivalence (2022)

IUPAC Standards Online DOI OpenAlex
58 Disulfiram Reaction (2022)

IUPAC Standards Online DOI OpenAlex
34 Catabolism (2022)

IUPAC Standards Online DOI OpenAlex
17 Anabolism (2022)

IUPAC Standards Online DOI OpenAlex
49 Dealkylation (2022)

IUPAC Standards Online DOI OpenAlex
192 Reactive Metabolites (2022)

IUPAC Standards Online DOI OpenAlex
205 Saturation Kinetics (2022)

IUPAC Standards Online DOI OpenAlex