Jinshan Jin
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
Researcher
Also affiliated: United States Food and Drug Administration (2016–2021); Georgia State University (2012–2021); Division of Undergraduate Education (2012); Food and Drug Administration (2021)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jinshan Jin's research focuses on the design, synthesis, and biological evaluation of novel SecA inhibitors. SecA is a key protein involved in bacterial protein translocation, and inhibiting its function can attenuate virulence and act as an antimicrobial strategy. Jin has published work detailing the development of pyrimidine analogs and thiouracil derivatives as SecA inhibitors, investigating their effectiveness against pathogens like Methicillin-resistant *Staphylococcus aureus* (MRSA) and *Bacillus anthracis*. Some of this research explores how these inhibitors can bypass bacterial efflux pumps, a common mechanism of antibiotic resistance. Additionally, Jin has investigated the optimization of sporulation and purification methods for assessing sporicidal efficacy and studied the dye-decolorizing capabilities of bacteria isolated from tattoo inks, an environment rich in azo dyes. Jin's scholarship metrics include an h-index of 13, with 24 total publications and 356 total citations.
Metrics
- h-index: 13
- Publications: 24
- Citations: 372
Selected Publications
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Optimization of sporulation and purification methods for sporicidal efficacy assessment on <i>Bacillus</i> spores (2022)
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Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes (2021)
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Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis (2021)
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Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes (2021)
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Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors (2021)
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Smokeless tobacco impacts oral microbiota in a Syrian Golden hamster cheek pouch carcinogenesis model (2018)
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Mutation network-based understanding of pleiotropic and epistatic mutational behavior of Enterococcus faecalis FMN-dependent azoreductase (2017)
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Evaluation of metabolism of azo dyes and their effects on<i>Staphylococcus aureus</i>metabolome (2017)
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Effect of smokeless tobacco products on human oral bacteria growth and viability (2016)
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Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram‐Negative Bacteria (2016)
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Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena (2016)
Collaboration Network
Top Collaborators
- Optimization of sporulation and purification methods for sporicidal efficacy assessment on <i>Bacillus</i> spores
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Optimization of sporulation and purification methods for sporicidal efficacy assessment on <i>Bacillus</i> spores
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