Jinshan Jin
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Also affiliated: United States Food and Drug Administration (2016–2026); Georgia State University (2012–2021)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jinshan Jin's research program focuses on the design, synthesis, and evaluation of novel antimicrobial agents, with a particular emphasis on targeting bacterial SecA proteins. SecA is a crucial component of the bacterial protein translocation machinery, making it a promising target for developing new antibacterial therapies. Jin has investigated various chemical scaffolds, including rose bengal analogues, triazole-pyrimidine derivatives, and thiouracils, to identify potent SecA inhibitors.
His work also extends to understanding the mechanisms of action of these inhibitors, including their differential effects on SecA-only and SecA-SecYEG protein-conducting channels. Jin has also explored the impact of environmental factors on microbial metabolomes, such as the metabolism of azo dyes by Staphylococcus aureus, and investigated the effects of smokeless tobacco on oral microbiota in a hamster model. His scholarship metrics include an h-index of 13, with 25 total publications and 374 citations.
Metrics
- h-index: 13
- Publications: 25
- Citations: 374
Selected Publications
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Evaluating the efficacy of disinfecting products against Bacillus subtilis spore using an optimized method (2026)
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Optimization of sporulation and purification methods for sporicidal efficacy assessment on Bacillus spores (2022)
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Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes (2021)
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Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis (2021)
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Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes (2021)
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Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors (2021)
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Smokeless tobacco impacts oral microbiota in a Syrian Golden hamster cheek pouch carcinogenesis model (2018)
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Mutation network-based understanding of pleiotropic and epistatic mutational behavior of Enterococcus faecalis FMN-dependent azoreductase (2017)
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Evaluation of metabolism of azo dyes and their effects onStaphylococcus aureusmetabolome (2017)
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Effect of smokeless tobacco products on human oral bacteria growth and viability (2016)
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Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram‐Negative Bacteria (2016)
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Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena (2016)
Collaboration Network
Top Collaborators
- Evaluation of metabolism of azo dyes and their effects onStaphylococcus aureusmetabolome
- Optimization of sporulation and purification methods for sporicidal efficacy assessment on Bacillus spores
- Effect of smokeless tobacco products on human oral bacteria growth and viability
- Smokeless tobacco impacts oral microbiota in a Syrian Golden hamster cheek pouch carcinogenesis model
- Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena
Showing 5 of 9 shared publications
- Evaluation of metabolism of azo dyes and their effects onStaphylococcus aureusmetabolome
- Effect of smokeless tobacco products on human oral bacteria growth and viability
- Smokeless tobacco impacts oral microbiota in a Syrian Golden hamster cheek pouch carcinogenesis model
- Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
Showing 5 of 7 shared publications
- Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram‐Negative Bacteria
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram‐Negative Bacteria
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram‐Negative Bacteria
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Evaluation of metabolism of azo dyes and their effects onStaphylococcus aureusmetabolome
- Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena
- Evaluation of metabolism of azo dyes and their effects onStaphylococcus aureusmetabolome
- Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena
- Effect of smokeless tobacco products on human oral bacteria growth and viability
- Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena
- Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram‐Negative Bacteria
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
- Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decolorize a wide range of azo dyes
- Phylogenetically diverse bacteria isolated from tattoo inks, an azo dye-rich environment, decoloize a wide range of azo dyes
- Optimization of sporulation and purification methods for sporicidal efficacy assessment on Bacillus spores
- Evaluating the efficacy of disinfecting products against Bacillus subtilis spore using an optimized method
- Optimization of sporulation and purification methods for sporicidal efficacy assessment on Bacillus spores
- Evaluating the efficacy of disinfecting products against Bacillus subtilis spore using an optimized method
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