E
En Huang
Federal Grant PI
Associate Professor
faculty
Environmental Health Sciences, College of Public Health
18 h-index
48 pubs
941 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
En Huang's research program centers on developing natural antimicrobial compounds to improve food safety and quality. A primary focus involves the discovery and characterization of natural antimicrobial peptides, such as bacteriocins, and lipopeptides, utilizing both chemical and genetic methodologies. These agents hold potential applications as natural food preservatives, additives for animal feed, or as novel antibiotics against drug-resistant bacterial pathogens. Another key area of investigation for Huang is the study of foodborne pathogens and spoilage microorganisms. This research employs genomic, transcriptomic, and metagenomic approaches to understand their transmission, ecology, and evolution.
Huang has served as PI on a grant from the NIH/National Institute of Allergy and Infectious Diseases for research into the mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens. With an h-index of 18 and over 900 citations, Huang has authored 48 publications. Collaborations within the University of Arkansas for Medical Sciences include work with Se-Ran Jun, Kaleb Z. Abram, Visanu Wanchai, and Intawat Nookaew.
Metrics
- h-index: 18
- Publications: 48
- Citations: 941
Selected Publications
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Genomic analysis, culturing optimization, and characterization of Escherichia bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce (2024)
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Treatment-emergent cefiderocol resistance in carbapenem-resistant <i>Acinetobacter baumannii</i> is associated with insertion sequence IS <i>Aba36</i> in the siderophore receptor <i>pirA</i> (2024)
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A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts (2024)
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Thermal Inactivation of Escherichia Phage OSYSP and Host Strain Escherichia coli O157:H7 EDL933: A Comparative Kinetic Analysis (2024)
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Lytic Escherichia phage OSYSP acts additively and synergistically with gaseous ozone against Escherichia coli O157:H7 on spinach leaves (2023)
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Carbapenem resistance in the food supply chain (2023)
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Cefiderocol Resistance in Klebsiella pneumoniae Is Linked to SHV Extended-Spectrum β-Lactamase Activities and Functional Loss of the Outer Membrane Porin OmpK35 (2023)
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Complete Genome Sequence of a Non-Carbapenemase-Producing Carbapenem-Resistant Providencia rettgeri Strain Isolated from a Clinical Urine Sample in Arkansas (2022)
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Cefiderocol heteroresistance in Klebsiella pneumoniae is linked to mutations in the siderophore receptor cirA and β-lactamase activities (2022)
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Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences (2022)
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Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection (2021)
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Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States (2021)
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Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable (2021)
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Applications in food technology: antimicrobial peptides (2021)
Federal Grants 1 $1 total
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Sep 2024 - Sep 2025
Grants & Funding
- Novel linear lipopeptide paenipeptins sensitize multidrug-resistant Gram-negative pathogens to antibiotics - Continuation Year 2020-2021 NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Real-Time High Resolution Method for Genomic Surveillance of ESKAPE pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
Collaboration Network
Top Collaborators
Ahmed E. Yousef
The Ohio State University (US)
5 shared publications
- Lytic Escherichia phage OSYSP acts additively and synergistically with gaseous ozone against Escherichia coli O157:H7 on spinach leaves
- Enhancing titre and production stability of paenibacillin from <i>Paenibacillus polymyxa</i> by sequential drug resistance screening
- Applications in food technology: antimicrobial peptides
- Thermal Inactivation of Escherichia Phage OSYSP and Host Strain Escherichia coli O157:H7 EDL933: A Comparative Kinetic Analysis
- Genomic analysis, culturing optimization, and characterization of Escherichia bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce
Sun Hee Moon
University of Arkansas for Medical Sciences (US)
4 shared publications
- Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States
- Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable
- Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences
- Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection
Xinhui Li
University of Wisconsin–La Crosse (US)
4 shared publications
- Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States
- Carbapenem resistance in the food supply chain
- Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable
- A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts
Xu Yang
California State Polytechnic University (US)
4 shared publications
- Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States
- Carbapenem resistance in the food supply chain
- Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable
- A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts
Emily Campbell
The Ohio State University (US)
3 shared publications
- Enhancing titre and production stability of paenibacillin from <i>Paenibacillus polymyxa</i> by sequential drug resistance screening
- Applications in food technology: antimicrobial peptides
- List of contributors
Zulema Udaondo
University of Arkansas for Medical Sciences (US)
3 shared publications
- Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States
- Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable
- Complete Genome Sequence of a Non-Carbapenemase-Producing Carbapenem-Resistant Providencia rettgeri Strain Isolated from a Clinical Urine Sample in Arkansas
Se‐Ran Jun
University of Arkansas for Medical Sciences
3 shared publications
In database
- Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States
- Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable
- Complete Genome Sequence of a Non-Carbapenemase-Producing Carbapenem-Resistant Providencia rettgeri Strain Isolated from a Clinical Urine Sample in Arkansas
Mustafa Yeşil
The Ohio State University (US)
3 shared publications
- Lytic Escherichia phage OSYSP acts additively and synergistically with gaseous ozone against Escherichia coli O157:H7 on spinach leaves
- Thermal Inactivation of Escherichia Phage OSYSP and Host Strain Escherichia coli O157:H7 EDL933: A Comparative Kinetic Analysis
- Genomic analysis, culturing optimization, and characterization of Escherichia bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce
Walaa E. Hussein
University of Cincinnati Medical Center (US)
2 shared publications
- Enhancing titre and production stability of paenibacillin from <i>Paenibacillus polymyxa</i> by sequential drug resistance screening
- Applications in food technology: antimicrobial peptides
Kaleb Z. Abram
University of Arkansas for Medical Sciences
2 shared publications
In database
- Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States
- Complete Genome Sequence of a Non-Carbapenemase-Producing Carbapenem-Resistant Providencia rettgeri Strain Isolated from a Clinical Urine Sample in Arkansas
Erin DiCaprio
University of California, Davis (US)
2 shared publications
- Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States
- A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts
Elizabeth Leighton
University of Wisconsin–La Crosse (US)
2 shared publications
- Carbapenem resistance in the food supply chain
- A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts
David R. Kasler
The Ohio State University (US)
2 shared publications
- Lytic Escherichia phage OSYSP acts additively and synergistically with gaseous ozone against Escherichia coli O157:H7 on spinach leaves
- Thermal Inactivation of Escherichia Phage OSYSP and Host Strain Escherichia coli O157:H7 EDL933: A Comparative Kinetic Analysis
Yihong Kaufmann
University of Arkansas for Medical Sciences
1 shared publication
In database
- Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection
Ryoichi Fujiwara
University of Arkansas for Medical Sciences (US)
1 shared publication
- Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection
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