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Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
John C. Marecki
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Instructor
Also affiliated: United States Department of Agriculture (2010); The University of Texas MD Anderson Cancer Center (2019); Johns Hopkins University (2006–2007); University of Arkansas Medical Center (2018); Johns Hopkins Medicine (2006–2007); Allegheny General Hospital (2006); University of Colorado Health (1993–2006); Arkansas Children's Nutrition Center (2007–2013); The University of Texas Medical Branch at Galveston (2019); University of California, Davis (2005–2006); University of Colorado Denver (2002–2006)
Biochemistry & Molecular Biology, College of Medicine
18 h-index
45 pubs
1,910 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
John C. Marecki's research has focused on cellular mechanisms underlying disease, particularly in the context of oxidative stress and inflammation. His work has investigated the accumulation of G-quadruplex DNA in the cytoplasm and its role in stress granule assembly in response to oxidative stress. Marecki has also explored the anti-inflammatory effects of thymoquinone in mouse models of allergic lung inflammation and asthma, examining its impact on cyclooxygenase expression and leukotriene biosynthesis. Earlier research included studies on the repression of manganese superoxide dismutase by the HIV-1 Tat protein and the association of HIV-1 Nef with pulmonary vascular lesions in macaques. He has collaborated extensively with researchers at the University of Arkansas for Medical Sciences, including Kevin D. Raney, Jun Gao, and Alicia K. Byrd. Marecki's scholarly output includes 45 publications with over 1,900 citations and an h-index of 18.
Metrics
- h-index: 18
- Publications: 45
- Citations: 1,910
Positions
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Instructor 2016–presentUniversity of Arkansas for Medical Sciences Biochemistry & Molecular Biology, College of Medicine Institutional directory
Selected Publications
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The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism (2026)
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Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir (2026)
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Abstract 5612 The UAMS Center for Molecular Interactions in Cancer (CMIC) Biomolecular Interactions Core (BIC) (2026)
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RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA (2026)
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Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir (2025)
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A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025)
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Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2025)
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RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA (2025)
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A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025)
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Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2024)
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Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024)
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Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024)
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RNA helicases required for viral propagation in humans (2021)
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A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA (2021)
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G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p (2021)
Grants & Funding
As listed on this researcher's institutional profile.
- Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids NIH Co-Investigator
- Mechanisms of Protection and Pathogenesis in ALS Mice NIH/Nat. Inst. of Neurological Disorders & Stroke Co-Investigator
- Coronavirus Genome Replication Subcontract UNC-CH Craig Cameron NIH/Nat. Inst. of Allergy & Infectious Diseases via University of North Carolina - Chapel Hill Principal Investigator
- Midwest AViDD Center NIH/Nat. Inst. of Allergy & Infectious Diseases via University of Minnesota Principal Investigator
- Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
Collaboration Network
Top Collaborators
Kevin D. Raney
University of Arkansas for Medical Sciences
19 shared publications
In database
- G-Quadruplex loops regulate PARP-1 enzymatic activation
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- RNA helicases required for viral propagation in humans
- N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3
- G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p
Showing 5 of 19 shared publications
Alicia K. Byrd
University of Arkansas Medical Center
9 shared publications
In database
- G-Quadruplex loops regulate PARP-1 enzymatic activation
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3
- G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
Showing 5 of 9 shared publications
Jun Gao
University of Arkansas for Medical Sciences
7 shared publications
In database
- G-Quadruplex loops regulate PARP-1 enzymatic activation
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- RNA helicases required for viral propagation in humans
- G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
Showing 5 of 7 shared publications
David Dulin
Vrije Universiteit Amsterdam (NL)
7 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Showing 5 of 7 shared publications
Thomas K. Anderson
University of Wisconsin–Madison (US)
6 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Showing 5 of 6 shared publications
Jamie J. Arnold
University of North Carolina at Chapel Hill (US)
6 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Showing 5 of 6 shared publications
Martin J. J. Ronis
Arkansas Children's Nutrition Center (US)
5 shared publications
- Maternal Overweight Programs Insulin and Adiponectin Signaling in the Offspring
- Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health
- Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
- Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats
- Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
Thomas M. Badger
Arkansas Children's Nutrition Center
5 shared publications
In database
- Maternal Overweight Programs Insulin and Adiponectin Signaling in the Offspring
- Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health
- Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
- Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats
- Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
Subhas Chandra Bera
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
5 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
- Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Kartik Shankar
Arkansas Children's Nutrition Center (US)
4 shared publications
- Maternal Overweight Programs Insulin and Adiponectin Signaling in the Offspring
- Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
- Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats
- Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
A. Edwards
University of Arkansas for Medical Sciences
4 shared publications
In database
- G-Quadruplex loops regulate PARP-1 enzymatic activation
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p
- G‐Quadruplex Loop Length Regulates PARP‐1 Enzymatic Activation
Misha Klein
Vrije Universiteit Amsterdam (NL)
4 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
- Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Arnab Das
Vrije Universiteit Amsterdam (NL)
4 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Flávia S. Papini
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
4 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Irina Artsimovitch
The Ohio State University (US)
4 shared publications
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
- Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
- Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
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