Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
A
Alicia K. Byrd
Federal Grant PI
High Impact
Assistant Professor
Also affiliated: Pennsylvania State University (2002); University of Arizona (2003); Vanderbilt University (2002); University of Arkansas Medical Center (2018); Winthrop Rockefeller Foundation (2021)
27 h-index
58 pubs
2,134 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Alicia K. Byrd leads a research group at the University of Arkansas for Medical Sciences focused on DNA helicases, their mechanisms, and regulation. Her work investigates how these enzymes interact with DNA, including their role in DNA unwinding and protein binding. A significant portion of her research also examines G-quadruplex DNA structures and their involvement in cellular processes, such as stress granule assembly in response to oxidative stress.
Dr. Byrd has received federal funding from the NIH/National Institute of General Medical Sciences for her research on DNA helicases, totaling $1,455,158. Her scholarship metrics include an h-index of 27, with 57 total publications and 1,973 total citations, designating her as a highly cited researcher. She has a history of collaboration with researchers at the University of Arkansas for Medical Sciences, including Matthew D. Thompson, Kevin D. Raney, Jun Gao, and John C. Marecki, with whom she has co-authored multiple publications.
Metrics
- h-index: 27
- Publications: 58
- Citations: 2,134
Positions
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Assistant Professor 2019–presentUniversity of Arkansas for Medical Sciences Biochemistry and Molecular Biology Institutional directory
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Instructor 2010–2018University of Arkansas for Medical Sciences Biochemistry and Molecular Biology ORCID
Selected Publications
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Response to the commentary by Melidis <i>et al.</i> on “Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments” (2025)
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Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments (2025)
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Rare SNP in the <i>HELB</i> gene interferes with RPA interaction and cellular function of HELB (2025)
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Structural and functional insights into the interaction between the bacteriophage T4 DNA processing proteins gp32 and Dda (2024)
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Untargeted CUT&Tag and BG4 CUT&Tag are both enriched at G-quadruplexes and accessible chromatin (2024)
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Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024)
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Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024)
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Rare SNP in the <i>HELB</i> gene interferes with RPA interaction and cellular function of HELB (2024)
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Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA (2023)
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Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures (2022)
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Alignment of helicases on single-stranded DNA increases activity (2022)
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Role and Regulation of Pif1 Family Helicases at the Replication Fork (2022)
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Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously (2022)
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A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp> (2021)
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G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p (2021)
Federal Grants 1 $1,455,158 total
NIH
Contact PI
Sep 2026 - Aug 2030
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Role of HELB in the Replication Stress Response NIH/NIGMS
- The effect of rs75770066, a stroke associated single nucleotide polymorphism, on enzyme activity UAMS Internal Research Awards
- Seeds of Science Pilot award UAMS Internal Research Awards
- DNA Helicases: Mechanism and Function NIH
- Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids NIH
- The Role of DNA Helicase B in Response to DNA Replication Stress UAMS Internal Research Awards
- Measurement of Helicase Diffusion and Cooperativity at the Single Molecule Level Burroughs Wellcome Fund
- Identification of synthetic lethal targets for treating breast cancer Arkansas Breast Cancer Research Program
- Role of HELB in the Replication Stress Response
Collaboration Network
Top Collaborators
Kevin D. Raney
University of Arkansas Medical Center
40 shared publications
In database
- Protein displacement by an assembly of helicase molecules aligned along single-stranded DNA
- Structure and Mechanisms of SF1 DNA Helicases
- Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- G-Quadruplex loops regulate PARP-1 enzymatic activation
Showing 5 of 40 shared publications
Jun Gao
University of Arkansas for Medical Sciences
12 shared publications
In database
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- G-Quadruplex loops regulate PARP-1 enzymatic activation
- Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4
Showing 5 of 12 shared publications
John C. Marecki
University of Arkansas for Medical Sciences
9 shared publications
In database
- G-Quadruplex loops regulate PARP-1 enzymatic activation
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3
- G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
Showing 5 of 9 shared publications
Matthew D. Thompson
Lyon College
9 shared publications
In database
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Role and Regulation of Pif1 Family Helicases at the Replication Fork
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments
- Untargeted CUT&Tag and BG4 CUT&Tag are both enriched at G-quadruplexes and accessible chromatin
Showing 5 of 9 shared publications
Shubeena Chib
University of Arkansas for Medical Sciences (US)
7 shared publications
- Yeast Pif1 Helicase Exhibits a One-base-pair Stepping Mechanism for Unwinding Duplex DNA
- Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA
- Yeast Helicase Pif1 Unwinds RNA:DNA Hybrids with Higher Processivity than DNA:DNA Duplexes
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4
Showing 5 of 7 shared publications
Maroof K. Zafar
University of Arkansas for Medical Sciences
7 shared publications
In database
- proteiNorm – A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification
- Genome Maintenance by DNA Helicase B
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
Showing 5 of 7 shared publications
Suja Aarattuthodiyil
University of Arkansas for Medical Sciences (US)
6 shared publications
- Structure and Mechanisms of SF1 DNA Helicases
- Erratum to: Structure and Mechanisms of SF1 DNA Helicases
- Yeast Pif1 Helicase Exhibits a One-base-pair Stepping Mechanism for Unwinding Duplex DNA
- Dda Helicase Tightly Couples Translocation on Single-Stranded DNA to Unwinding of Duplex DNA: Dda Is an Optimally Active Helicase
- N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3
Showing 5 of 6 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
4 shared publications
In database
- Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- Hepatitis C Virus NS3 and Simian Virus 40 T Antigen Helicases Displace Streptavidin from 5‘-Biotinylated Oligonucleotides but Not from 3‘-Biotinylated Oligonucleotides: Evidence for Directional Bias in Translocation on Single-Stranded DNA
- Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
4 shared publications
In database
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- Investigation of Translocation, DNA Unwinding, and Protein Displacement by NS3h, the Helicase Domain from the Hepatitis C Virus Helicase
Wezley C. Griffin
University of Arkansas for Medical Sciences (US)
4 shared publications
- Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA
- A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4
- Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA
- The Structural Recognition of G‐quadruplex DNA by PC4: How Does a ssDNA Binding Protein Decide?
A. Edwards
University of Arkansas for Medical Sciences
4 shared publications
In database
- G-Quadruplex loops regulate PARP-1 enzymatic activation
- DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA
- G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p
- G‐Quadruplex Loop Length Regulates PARP‐1 Enzymatic Activation
Lindsey Hazeslip
University of Arkansas for Medical Sciences
4 shared publications
In database
- Genome Maintenance by DNA Helicase B
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
Emory G. Malone
University of Arkansas for Medical Sciences
4 shared publications
In database
- Role and Regulation of Pif1 Family Helicases at the Replication Fork
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously
Stephanie D. Byrum
Arkansas Children's Hospital
3 shared publications
In database
- proteiNorm – A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
Wayne P. Wahls
University of Arkansas for Medical Sciences
3 shared publications
In database
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth
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