Match tier
Likely match
Presence
Current · Arkansas
Last published
2020
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
J
John F. Bowyer
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Senior Research Pharmacologist
Also affiliated: United States Food and Drug Administration (1995–2020); University of Colorado Anschutz (1990); Case Western Reserve University (2001); University of California, Davis (1978–1983); University of Colorado Denver (1990)
34 h-index
114 pubs
4,147 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
John F. Bowyer is a Senior Research Pharmacologist at the National Center for Toxicological Research. His work has focused on the pharmacological effects of substances and their toxicity. Bowyer has contributed to the scientific literature with publications in this area. His research activities are primarily associated with toxicological studies.
Metrics
- h-index: 34
- Publications: 114
- Citations: 4,147
Positions
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Senior Research Pharmacologist 1992–presentNCTR/ FDA Neurotoxicology ORCID
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Senior Research Pharmacologist publications 1991–2020National Center for Toxicological Research ORCID
Selected Publications
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Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat (2020)
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Microglial activation and responses to vasculature that result from an acute LPS exposure (2020)
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Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats (2019)
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The time course of blood brain barrier leakage and its implications on the progression of methamphetamine-induced seizures (2018)
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Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency (2018)
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Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine (2017)
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Multi-class computational evolution: development, benchmark evaluation and application to RNA-Seq biomarker discovery (2017)
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Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat (2016)
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Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair? (2016)
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Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood (2015)
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An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data (2015)
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Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model (2014)
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Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity (2014)
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Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity (2013)
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Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity (2013)
Collaboration Network
Top Collaborators
William Slikker
National Center for Toxicological Research
18 shared publications
In database
- Further studies of the role of hyperthermia in methamphetamine neurotoxicity.
- The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
- Nitric oxide regulation of methamphetamine-induced dopamine release in caudate/putamen
Showing 5 of 18 shared publications
Glenn D. Newport
National Center for Toxicological Research
17 shared publications
In database
- Further studies of the role of hyperthermia in methamphetamine neurotoxicity.
- The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
- Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
Showing 5 of 17 shared publications
R.Robert Holson
National Center for Toxicological Research (US)
16 shared publications
- Further studies of the role of hyperthermia in methamphetamine neurotoxicity.
- The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
- Nitric oxide regulation of methamphetamine-induced dopamine release in caudate/putamen
Showing 5 of 16 shared publications
Joseph P. Hanig
United States Food and Drug Administration (US)
14 shared publications
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Microglial activation and responses to vasculature that result from an acute LPS exposure
- Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague–Dawley rats during the waking (lights off) cycle
- Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
Showing 5 of 14 shared publications
Peter Clausing
National Center for Toxicological Research (US)
14 shared publications
- Nitric oxide regulation of methamphetamine-induced dopamine release in caudate/putamen
- Amphetamine levels in brain microdialysate, caudate/putamen, substantia nigra and plasma after dosage that produces either behavioral or neurotoxic effects.
- Long-term Effects of Amphetamine Neurotoxicity on Tyrosine Hydroxylase mRNA and Protein in Aged Rats
- Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
- d-Fenfluramine produces neuronal degeneration in localized regions of the cortex, thalamus, and cerebellum of the rat
Showing 5 of 14 shared publications
Nysia I. George
National Center for Toxicological Research
12 shared publications
In database
- An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague–Dawley rats during the waking (lights off) cycle
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
- Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
Showing 5 of 12 shared publications
Syed F. Ali
9 shared publications
In database
- The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus
- Neurotoxic‐related changes in tyrosine hydroxylase, microglia, myelin, and the blood‐brain barrier in the caudate‐putamen from acute methamphetamine exposure
- Low Environmental Temperatures or Pharmacologic Agents That Produce Hypothermia Decrease Methamphetamine Neurotoxicity in Mice
Showing 5 of 9 shared publications
Robert R. Delongchamp
National Center for Toxicological Research
8 shared publications
In database
- Multiple‐Testing Strategy for Analyzing cDNA Array Data on Gene Expression
- The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus–pituitary–thyroid axis of male Fischer 344 rats
- A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes
- Selective Changes in Gene Expression in Cortical Regions Sensitive to Amphetamine During the Neurodegenerative Process
- The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water
Showing 5 of 8 shared publications
James P. O’Callaghan
Centers for Disease Control and Prevention (US)
7 shared publications
- Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine
- Microglial activation and responses to vasculature that result from an acute LPS exposure
- A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes
- Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
- Phenobarbital and dizocilpine can block methamphetamine-induced neurotoxicity in mice by mechanisms that are independent of thermoregulation
Showing 5 of 7 shared publications
Daniel R. Doerge
National Center for Toxicological Research
7 shared publications
In database
- Quantification of rat brain neurotransmitters and metabolites using liquid chromatography/electrospray tandem mass spectrometry and comparison with liquid chromatography/electrochemical detection
- The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus–pituitary–thyroid axis of male Fischer 344 rats
- Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague–Dawley rats during the waking (lights off) cycle
- Metabolomic analysis of urine from rats chronically dosed with acrylamide using NMR and LC/MS
Showing 5 of 7 shared publications
Larry Schmued
National Center for Toxicological Research (US)
7 shared publications
- Methamphetamine exposure can produce neuronal degeneration in mouse hippocampal remnants
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin
- Neurotoxic‐related changes in tyrosine hydroxylase, microglia, myelin, and the blood‐brain barrier in the caudate‐putamen from acute methamphetamine exposure
- Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
Showing 5 of 7 shared publications
Monzy Thomas
National Center for Toxicological Research (US)
7 shared publications
- Brain Region–Specific Neurodegenerative Profiles Showing the Relative Importance of Amphetamine Dose, Hyperthermia, Seizures, and the Blood–Brain Barrier
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
- Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure
- Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature
Showing 5 of 7 shared publications
Sumit Sarkar
National Center for Toxicological Research
7 shared publications
In database
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Microglial activation and responses to vasculature that result from an acute LPS exposure
- Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
- Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
- Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency
Showing 5 of 7 shared publications
Karen M. Tranter
National Center for Toxicological Research (US)
6 shared publications
- Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
- Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
- Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency
- Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood
- The time course of blood brain barrier leakage and its implications on the progression of methamphetamine-induced seizures
Showing 5 of 6 shared publications
George W. Lipe
5 shared publications
- Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
- Interactions of MK-801 with glutamate-, glutamine- and methamphetamine-evoked release of [3H]dopamine from striatal slices.
- A further evaluation of the effects of K+ depolarization on glutamate-evoked [3H]dopamine release from striatal slices.
- Comparison of Glutamine‐Enhanced Glutamate Release from Slices and Primary Cultures of Rat Brain
- Age and Dietary Factors in Hippocampal Sensitivity to Trimethyltin
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