John F. Bowyer
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Senior Research Pharmacologist
Also affiliated: United States Food and Drug Administration (2007–2019); University of Colorado Health (1989–1992); Food and Drug Administration (2014); Case Western Reserve University (2001); University of California, Davis (1978–1983); University of Colorado Denver (1990)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
John F. Bowyer is a Senior Research Pharmacologist at the National Center for Toxicological Research. His work has focused on the pharmacological effects of substances and their toxicity. Bowyer has contributed to the scientific literature with publications in this area. His research activities are primarily associated with toxicological studies.
Metrics
- h-index: 34
- Publications: 118
- Citations: 4,142
Selected Publications
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Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat (2020)
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Microglial activation and responses to vasculature that result from an acute LPS exposure (2020)
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Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats (2019)
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The time course of blood brain barrier leakage and its implications on the progression of methamphetamine-induced seizures (2018)
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Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency (2018)
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Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine (2017)
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Multi-class computational evolution: development, benchmark evaluation and application to RNA-Seq biomarker discovery (2017)
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Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat (2016)
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Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair? (2016)
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Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood (2015)
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An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data (2015)
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Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model (2014)
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Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity (2014)
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Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity (2013)
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Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity (2013)
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