Joseph H. Holthoff
Assistant Professor
faculty
Internal Med, College of Medicine
7 h-index
37 pubs
782 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Joseph H. Holthoff's research focuses on understanding and identifying biomarkers for acute kidney injury (AKI), particularly in the context of cardiothoracic surgery. His work investigates specific molecules, such as SOD1, urinary complement C3, and vitamin D-binding protein, as potential indicators of adverse outcomes in patients with AKI. Dr. Holthoff also explores the role of proteins like Esm-1 in diabetic kidney disease and IGFBP-1 in the clinical prognosis and pathophysiology of AKI. His investigations extend to other kidney-related conditions, including polycystic kidney disease and membranous nephropathy, and he has examined the efficacy of different treatments for hypermagnesemia. Dr. Holthoff collaborates with researchers at the University of Arkansas for Medical Sciences, including Nithin Karakala, Luis A. Juncos, Manisha Singh, and Fatima Ayub. He has authored 37 publications, with an h-index of 7 and over 775 citations.
Metrics
- h-index: 7
- Publications: 37
- Citations: 782
Selected Publications
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Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction (2025)
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The Second Slice Tells the Story: Evolving Cryoglobulinemia in Mesangial Glomerulonephritis (2025)
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Dialysate Sodium (2025)
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SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series (2025)
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Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy (2025)
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The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury (2025)
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Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy (2024)
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New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024)
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Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care (2024)
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New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024)
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I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy (2023)
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The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor (2023)
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SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery (2023)
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SAT145 Familial Renal Glycosuria - A Differential Diagnosis For Hypoglycemia (2023)
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Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion (2022)
Grants & Funding
- Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury Dialysis Clinic, Inc. Principal Investigator
- Preclinical evaluation of resveratrol in sepsis-induced renal injury NIH Principal Investigator
- Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury Dialysis Clinic, Inc. Principal Investigator
Collaboration Network
Top Collaborators
John M. Arthur
University of Arkansas for Medical Sciences (US)
7 shared publications
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
Showing 5 of 7 shared publications
Nithin Karakala
University of Arkansas for Medical Sciences
6 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Showing 5 of 6 shared publications
Fatima Ayub
Central Arkansas Veterans Healthcare System (US)
5 shared publications
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- “Tag - You're It!” Use of Tagged Red Blood Cell (RBC) Scan to Localize Gross Hematuria
- I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
- Dialysate Sodium
Luis A. Juncos
University of Arkansas for Medical Sciences
4 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The Role of Esm-1 in Diabetic Kidney Disease: More Than Just a Biomarker
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
Md R. Hasan
4 shared publications
- “Tag - You're It!” Use of Tagged Red Blood Cell (RBC) Scan to Localize Gross Hematuria
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Christian Herzog
Central Arkansas Veterans Healthcare System
3 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- Urine Mass Spectrometry Can Distinguish Prerenal and Intrarenal AKI
Fatima Ayub
University of Arkansas for Medical Sciences
3 shared publications
In database
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion
Manisha Singh
University of Arkansas for Medical Sciences
3 shared publications
In database
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Yanping Izak Harville
University of Arkansas for Medical Sciences
2 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
Nithin Karakala
University of Arkansas for Medical Sciences (US)
2 shared publications
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- “Tag - You're It!” Use of Tagged Red Blood Cell (RBC) Scan to Localize Gross Hematuria
Ahmed Abdallah
University of Arkansas for Medical Sciences (US)
2 shared publications
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy
Praveen Errabelli
2 shared publications
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Yazan A. Bashtawi
University of Arkansas for Medical Sciences (US)
2 shared publications
- Nephrogenic Diabetes Insipidus Secondary to Foscarnet
- Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion
Vanya Rai
Mayo Clinic in Florida (US)
2 shared publications
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
Sreelakshmi Ravula
University of Arkansas for Medical Sciences (US)
2 shared publications
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction
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