Match tier
Listed
Presence
Current · Arkansas
Last published
2023
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Keith R. McCain
Associate Professor
Also affiliated: University of Arkansas Medical Center (2018)
Poision Control, College of Pharmacy
10 h-index
12 pubs
502 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Keith R. McCain's research focuses on the metabolism and toxicology of novel psychoactive substances, particularly synthetic cannabinoids. His work investigates the enzymes involved in the oxidative metabolism of these compounds, with a recent publication identifying the specific cytochrome P450 enzymes responsible for the metabolism of the synthetic cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019). McCain has a scholarly record of 12 publications, with a total of 499 citations and an h-index of 10. He collaborates with other researchers, including William E. Fantegrossi at the University of Arkansas for Medical Sciences, with whom he shares one publication. McCain's work contributes to understanding the pharmacokinetic and pharmacodynamic profiles of substances relevant to substance-related disorders.
Metrics
- h-index: 10
- Publications: 12
- Citations: 502
Positions
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Associate Professor 2000–presentUniversity of Arkansas for Medical Sciences College of Pharmacy Pharmacy Practice ORCID
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Associate Professor publications 2007–2023University of Arkansas for Medical Sciences Poision Control, College of Pharmacy Institutional directory
Selected Publications
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Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019) (2023)
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Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity (2020)
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Impaired Driving Associated with the Synthetic Cannabinoid 5F-ADB (2018)
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Use and Risk Perception of Electronic Nicotine Delivery Systems and Tobacco in Pregnancy (2018)
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Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants (2018)
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Electronic cigarette use, knowledge, and perceptions among health professional students (2017)
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Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology (2013)
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Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds (2013)
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K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure (2013)
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Not simply synthetic tetrahydrocannabinol (2013)
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Comparison of the Effects of Energy Drink Versus Caffeine Supplementation on Indices of 24-Hour Ambulatory Blood Pressure (2012)
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Evaluation of Centrally Acting Cholinesterase Inhibitor Exposures in Adults (2007)
Grants & Funding
As listed on this researcher's institutional profile.
- Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH/NIDA Co-Investigator
- Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH Co-Investigator
Collaboration Network
Top Collaborators
William E. Fantegrossi
University of Arkansas for Medical Sciences
6 shared publications
In database
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity
- Not simply synthetic tetrahydrocannabinol
Showing 5 of 6 shared publications
Jeffery H. Moran
Arkansas Department of Health
5 shared publications
In database
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Not simply synthetic tetrahydrocannabinol
Anna Radomińska‐Pandya
University of Arkansas for Medical Sciences
5 shared publications
In database
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity
Amy Patton
Arkansas Department of Health (US)
4 shared publications
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Laura P. James
University of Arkansas for Medical Sciences
4 shared publications
In database
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Kathryn A. Seely
Arkansas Department of Health (US)
3 shared publications
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Paul L. Prather
University of Arkansas for Medical Sciences
3 shared publications
In database
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity
Amy M. Franks
University of Arkansas for Medical Sciences
3 shared publications
In database
- Comparison of the Effects of Energy Drink Versus Caffeine Supplementation on Indices of 24-Hour Ambulatory Blood Pressure
- Electronic cigarette use, knowledge, and perceptions among health professional students
- Use and Risk Perception of Electronic Nicotine Delivery Systems and Tobacco in Pregnancy
Ryoichi Fujiwara
University of Arkansas for Medical Sciences (US)
3 shared publications
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity
- Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019)
Krishna C. Chimalakonda
University of Arkansas for Medical Sciences (US)
2 shared publications
- K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
Cindy L. Moran
Arkansas State University (US)
2 shared publications
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure
Gregory W. Endres
Cayman Chemical (United States) (US)
2 shared publications
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
Nalin Payakachat
University of Arkansas Medical Center (US)
2 shared publications
- Electronic cigarette use, knowledge, and perceptions among health professional students
- Use and Risk Perception of Electronic Nicotine Delivery Systems and Tobacco in Pregnancy
Azure L. Yarbrough
University of Arkansas at Little Rock
2 shared publications
In database
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity
Robert S. Hoffman
New York University (US)
1 shared publication
- Not simply synthetic tetrahydrocannabinol
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