Keith R. McCain
Associate Professor
Also affiliated: American Association of Poison Control Centers (2007)
Faculty Researcher
Poision Control, College of Pharmacy
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Keith R. McCain's research focuses on the metabolism and toxicology of novel psychoactive substances, particularly synthetic cannabinoids. His work investigates the enzymes involved in the oxidative metabolism of these compounds, with a recent publication identifying the specific cytochrome P450 enzymes responsible for the metabolism of the synthetic cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019). McCain has a scholarly record of 12 publications, with a total of 499 citations and an h-index of 10. He collaborates with other researchers, including William E. Fantegrossi at the University of Arkansas for Medical Sciences, with whom he shares one publication. McCain's work contributes to understanding the pharmacokinetic and pharmacodynamic profiles of substances relevant to substance-related disorders.
Metrics
- h-index: 10
- Publications: 12
- Citations: 500
Selected Publications
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Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019) (2023)
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Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity (2020)
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Impaired Driving Associated with the Synthetic Cannabinoid 5F-ADB (2018)
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Use and Risk Perception of Electronic Nicotine Delivery Systems and Tobacco in Pregnancy (2018)
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Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants (2018)
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Electronic cigarette use, knowledge, and perceptions among health professional students (2017)
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Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology (2013)
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Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds (2013)
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K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure (2013)
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Not simply synthetic tetrahydrocannabinol (2013)
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Comparison of the Effects of Energy Drink Versus Caffeine Supplementation on Indices of 24-Hour Ambulatory Blood Pressure (2012)
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Evaluation of Centrally Acting Cholinesterase Inhibitor Exposures in Adults (2007)
Grants & Funding
As listed on this researcher's institutional profile.
- Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH/NIDA Co-Investigator
- Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH Co-Investigator
Collaboration Network
Top Collaborators
- Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019)
- Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019)
- Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019)
- Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019)
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