William E. Fantegrossi
High Impact
Professor
faculty
Pharmacology & Toxicology, College of Medicine
41 h-index
165 pubs
5,119 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
William E. Fantegrossi's research program focuses on the preclinical evaluation of drugs of abuse and potential therapeutic agents. His work investigates the pharmacological effects of various psychoactive compounds, including synthetic cannabinoids, substituted amphetamines, and novel arylcyclohexylamines, in rodent models. This research aims to understand the mechanisms underlying drug dependence, withdrawal, and the neurocognitive effects associated with these substances.
Fantegrossi's laboratory also explores the potential therapeutic applications of certain compounds, such as MDMA analogues, for conditions like autism spectrum disorder. His research utilizes a range of behavioral and physiological assessments to characterize drug effects, including dose-response relationships, tolerance development, and the interaction of these compounds with neurotransmitter systems. He has published extensively in this field, with a notable body of work on the abuse liability and neurobiological impact of novel psychoactive substances. His scholarship metrics include an h-index of 40, with over 5,000 citations across 164 publications.
His federally funded work includes a $496,311 award from the National Institute on Drug Abuse (NIDA) for a project focused on translational training in addiction. Fantegrossi collaborates with several researchers at the University of Arkansas for Medical Sciences, including Brenda M. Gannon and Jeffery H. Moran.
Metrics
- h-index: 41
- Publications: 165
- Citations: 5,119
Selected Publications
-
Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses (2026)
-
Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations (2025)
-
Effects of psychostimulants on locomotor activity in the BTBR T+ Itpr3tf/J mouse: implications for comorbid autism spectrum disorder and attention deficit hyperactivity disorder (2025)
-
In vitro and in vivo pharmacological characterization of fentanyl analogs (2025)
-
Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption (2025)
-
Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice (2025)
-
NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025)
-
DRUG-DRUG INTERACTIONS RELEVANT TO SUBSTANCE ABUSE AND TOXICITY (2025)
-
A “Furious” Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics (2024)
-
Respiratory Depressant Effects of Fentanyl in Combination With Synthetic Cannabinoid Receptor Agonists: A Potential Mechanism for “Narcan-Resistant” Overdose (2024)
-
Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917] (2024)
-
Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents (2024)
-
Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones (2023)
-
Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations (2023)
-
Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety (2023)
Federal Grants 1 $496,311 total
NIH/National Institute on Drug Abuse
Co-PI
Jul 2009 - Jun 2029
Grants & Funding
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
- Effects of self-administered MDMA on brain and behavior in rhesus monkeys NIH Principal Investigator
- No FP attached UAMS College of Medicine Principal Investigator
- No FP attached UAMS College of Medicine Principal Investigator
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
- In vivo pharmacological studies for abuse liability testing - Continuation U.S. Food and Drug Administration Principal Investigator
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
Collaboration Network
Top Collaborators
Brenda M. Gannon
University of Arkansas for Medical Sciences
9 shared publications
In database
- Effects of Laboratory Housing Conditions on Core Temperature and Locomotor Activity in Mice
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
- Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents
- Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety
Showing 5 of 9 shared publications
Hannah E. Shaw
University of Arkansas for Medical Sciences
5 shared publications
In database
- Balancing Therapeutic Efficacy and Safety of MDMA and Novel MDXX Analogues as Novel Treatments for Autism Spectrum Disorder
- Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents
- Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption
- Effects of psychostimulants on locomotor activity in the BTBR T+ Itpr3tf/J mouse: implications for comorbid autism spectrum disorder and attention deficit hyperactivity disorder
Jeffery H. Moran
nPoint (United States)
5 shared publications
In database
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption
- DRUG-DRUG INTERACTIONS RELEVANT TO SUBSTANCE ABUSE AND TOXICITY
- Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses
Paul L. Prather
4 shared publications
- Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes
- Major Metabolites of the Synthetic Cannabinoid 5F‐ADB Retain High Affinity and Full Efficacy at CB1 Receptors; Potential Mechanism Contributing to Enhanced Toxicity?
- 5F-APINACA kin&pheno-HLM&MLM.xlsx
Lauren R. Fitzgerald
University of Arkansas for Medical Sciences
4 shared publications
In database
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
- Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety
- Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917]
Marina Avram
nPoint (United States)
4 shared publications
In database
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption
- Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses
Takato Hiranita
Florida College (US)
3 shared publications
- Cannabimimetic effects of abused indazole-carboxamide synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA and 5F-ADB-PINACA in mice: Tolerance, dependence and withdrawal
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
- In vitro and in vivo pharmacological characterization of fentanyl analogs
Lauren Russell
University of Arkansas for Medical Sciences
2 shared publications
In database
- Effects of Laboratory Housing Conditions on Core Temperature and Locomotor Activity in Mice
- Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors
Christian V. Cabanlong
University of Arkansas for Medical Sciences (US)
2 shared publications
- Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors
- Major Metabolites of the Synthetic Cannabinoid 5F‐ADB Retain High Affinity and Full Efficacy at CB1 Receptors; Potential Mechanism Contributing to Enhanced Toxicity?
Catheryn D. Wilson
University of Arkansas for Medical Sciences
2 shared publications
In database
- Cannabimimetic effects of abused indazole-carboxamide synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA and 5F-ADB-PINACA in mice: Tolerance, dependence and withdrawal
- Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice
Samantha Crosby
2 shared publications
In database
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes
- 5F-APINACA kin&pheno-HLM&MLM.xlsx
Laura Osborn
2 shared publications
In database
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes
- 5F-APINACA kin&pheno-HLM&MLM.xlsx
Mary A. Schleiff
2 shared publications
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes
- 5F-APINACA kin&pheno-HLM&MLM.xlsx
Swati Nagar
2 shared publications
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes
- 5F-APINACA kin&pheno-HLM&MLM.xlsx
Gunnar Boysen
2 shared publications
In database
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes
- 5F-APINACA kin&pheno-HLM&MLM.xlsx
Similar Researchers
Based on overlapping research topics
William Fantegrossi
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Neuroscience and Neuropharmacology Research
Cannabis and Cannabinoid Research
A. George Wilson
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Neuroscience and Neuropharmacology Research
Substance Abuse Treatment and Outcomes
J S James
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Neuroscience and Neuropharmacology Research
Cannabis and Cannabinoid Research
Brenda M. Gannon
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Neuroscience and Neuropharmacology Research
Cannabis and Cannabinoid Research
Stephen A. Fagot
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Neuroscience and Neuropharmacology Research
Substance Abuse Treatment and Outcomes
Taher M Yusufali
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Neuroscience and Neuropharmacology Research
Cannabis and Cannabinoid Research