Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
William E. Fantegrossi
Federal Grant PI
High Impact
Professor
Also affiliated: Oregon National Primate Research Center (2008); University of Maryland, Baltimore (2024); National Institutes of Health (1997); Apple (Israel) (2021); National Institute on Drug Abuse (2016); Emory Healthcare (2006–2007); Children's Hospital of Philadelphia (2020); Uniformed Services University of the Health Sciences (1996); Emory University (2005–2010); American University (1998); Georgia State University (2007); Virginia Commonwealth University (2014); University of Michigan (1999–2011); University of Arkansas Medical Center (2010–2025); Hunter College (2010); National Institute of Diabetes and Digestive and Kidney Diseases (1997); National Institute on Alcohol Abuse and Alcoholism (2016); Deutsch Amerikanisches Institut Saarland (2004); Arkansas Department of Agriculture (2015–2017); Emory National Primate Research Center (2007–2010); University of Pennsylvania (2020); Walter Reed Army Institute of Research (1995)
Faculty Researcher
Pharmacology & Toxicology, College of Medicine
41 h-index
166 pubs
5,193 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
William E. Fantegrossi's research program focuses on the pharmacological effects and toxicity of various classes of psychoactive drugs, with a particular emphasis on substances of abuse and potential therapeutic agents. His work investigates the interactions of these compounds with specific receptor systems, including cannabinoid and serotonin receptors, and their impact on behavior and physiological responses in preclinical models. Fantegrossi has studied the abuse liability, neurocognitive effects, and withdrawal symptoms associated with novel synthetic cannabinoids, phencyclidine analogs, and substituted amphetamines.
His research also extends to the potential therapeutic applications of compounds like MDMA and its analogs for conditions such as autism spectrum disorder. Fantegrossi has received federal funding for training in systems pharmacology and toxicology. His scholarly contributions are evidenced by a high h-index of 41, over 165 publications, and more than 5,170 citations. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Brenda M. Gannon, Hannah E. Shaw, Jeffery H. Moran, and Lauren R. Fitzgerald, and leads a research group.
Metrics
- h-index: 41
- Publications: 166
- Citations: 5,193
Selected Publications
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Interoceptive effects of N1-substituted lysergamides in rats: role of agonist affinity at 5-HT receptors and in vivo metabolism to lysergic acid diethylamide (LSD) (2026)
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Behavioral and Pharmacokinetic Implications of Synthetic Cannabinoid Receptor Agonist and Benzodiazepine Co-Administration in C57BL/6 Mice (Abstract ID: 221452) (2026)
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Effects of Psychedelics Lysergic Acid Diethylamide and <i>R</i> (–)-2,5-Dimethoxy-4-Iodoamphetamine on Oral Opioid Consumption and Naloxone-Precipitated Withdrawal in Male C57Bl/6J Mice (2026)
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Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses (2026)
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Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations (2025)
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Effects of psychostimulants on locomotor activity in the BTBR T+ Itpr3tf/J mouse: implications for comorbid autism spectrum disorder and attention deficit hyperactivity disorder (2025)
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In vitro and in vivo pharmacological characterization of fentanyl analogs (2025)
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Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption (2025)
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Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice (2025)
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NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025)
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DRUG-DRUG INTERACTIONS RELEVANT TO SUBSTANCE ABUSE AND TOXICITY (2025)
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A “Furious” Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics (2024)
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Respiratory Depressant Effects of Fentanyl in Combination With Synthetic Cannabinoid Receptor Agonists: A Potential Mechanism for “Narcan-Resistant” Overdose (2024)
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Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917] (2024)
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Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents (2024)
Federal Grants 2 $864,148 total
NIH
Contact PI
Jul 2026 - Apr 2031
Abuse-related and neurocognitive consequences of halogenated arylcyclohexylamines.
NIH
Contact PI
Jul 2023 - Jun 2028
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Translational Training in Addiction NIH/Nat. Inst. on Drug Abuse Principal Investigator
- Effects of self-administered MDMA on brain and behavior in rhesus monkeys NIH Principal Investigator
- In vivo pharmacological studies for abuse liability testing - Continuation U.S. Food and Drug Administration Principal Investigator
- Translational training in addiction NIH/NIDA Other Key Personnel
- INTRAVENOUS SELF ADMINISTRATION OF MDMA NIH Principal Investigator
- Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH Co-Investigator
- Evaluation of Hallucinogenic Substances using the Drug Discrimination Assay US Department of Justice Principal Investigator
- Evaluation of enantiomer combinations of MDXX drugs in mouse models of autism PharmAla Biotech Principal Investigator
- Antibody Gene Therapy for Methamphetamine Abuse NIH Co-Investigator
- Pharmacology and Therapy for MDPV and alpha-PVP Like Drugs of Abuse NIH/Nat. Inst. on Drug Abuse Co-Investigator
Collaboration Network
Top Collaborators
Brenda M. Gannon
University of Arkansas for Medical Sciences
8 shared publications
In database
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
- Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption
- Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety
Showing 5 of 8 shared publications
Jeffery H. Moran
nPoint (United States)
5 shared publications
In database
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption
- Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice
- DRUG-DRUG INTERACTIONS RELEVANT TO SUBSTANCE ABUSE AND TOXICITY
- Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses
Lauren R. Fitzgerald
University of Arkansas for Medical Sciences
4 shared publications
In database
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
- Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety
- Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917]
Marina Avram
nPoint (United States)
4 shared publications
In database
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption
- Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice
- Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses
Hannah E. Shaw
University of Arkansas for Medical Sciences
4 shared publications
In database
- Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption
- Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice
- Effects of psychostimulants on locomotor activity in the BTBR T+ Itpr3tf/J mouse: implications for comorbid autism spectrum disorder and attention deficit hyperactivity disorder
Paul L. Prather
University of Arkansas for Medical Sciences
3 shared publications
In database
- Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors
- Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes
- Major Metabolites of the Synthetic Cannabinoid 5F‐ADB Retain High Affinity and Full Efficacy at CB1 Receptors; Potential Mechanism Contributing to Enhanced Toxicity?
Takato Hiranita
Florida College (US)
3 shared publications
- Cannabimimetic effects of abused indazole-carboxamide synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA and 5F-ADB-PINACA in mice: Tolerance, dependence and withdrawal
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
- In vitro and in vivo pharmacological characterization of fentanyl analogs
Christian V. Cabanlong
University of Arkansas for Medical Sciences (US)
2 shared publications
- Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors
- Major Metabolites of the Synthetic Cannabinoid 5F‐ADB Retain High Affinity and Full Efficacy at CB1 Receptors; Potential Mechanism Contributing to Enhanced Toxicity?
Catheryn D. Wilson
University of Arkansas for Medical Sciences
2 shared publications
In database
- Cannabimimetic effects of abused indazole-carboxamide synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA and 5F-ADB-PINACA in mice: Tolerance, dependence and withdrawal
- Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice
Christopher O. Godwin
University of Arkansas for Medical Sciences
2 shared publications
In database
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety
- Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917]
Heidi D. Hughes-Meredith
University of Arkansas for Medical Sciences
2 shared publications
In database
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety
- Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917]
Kenner C. Rice
National Institute on Alcohol Abuse and Alcoholism (US)
2 shared publications
- Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety
- Erratum to “Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety” [Drug Alcohol Depend. 250 (2023) 110917]
Mitchell R. McGill
University of Arkansas for Medical Sciences
2 shared publications
In database
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen
Laura P. James
Arkansas Department of Agriculture
2 shared publications
In database
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen
Gregory W. Endres
nPoint (United States) (US)
2 shared publications
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses
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