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Biography and Research Information
OverviewAI-generated summary
Charity L. Washam's research focuses on the application of multi-omics data integration to understand disease mechanisms. Her work includes the development of computational tools for quantitative proteomics, such as the proteoDA package. Washam has investigated cellular heterogeneity and transcriptomic profiling in mice infected with Leishmania major, exploring the impact of HIF-α activation on macrophage function during infection. Her studies also extend to cancer research, examining correlated regulatory features of triple-negative breast cancer through multi-omics data integration. Additionally, she has explored the potential of proteomic profiling of tear fluid as a non-invasive screening method for colon cancer and investigated exosomal microRNA and protein profiles in hepatocellular carcinoma. Washam has published 56 papers, with 1,082 citations, and maintains an h-index of 14. She collaborates with researchers at the University of Arkansas for Medical Sciences, including Stephanie D. Byrum, Duah Alkam, Allen Gies, and Samuel G. Mackintosh.
Metrics
- h-index: 14
- Publications: 57
- Citations: 1,105
Selected Publications
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Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during <i>L. major</i> infection and promote host defense to infection (2026)
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Rescue of Angiopoietin‐2 Inhibits Proliferation of Lymphatic Malformation Endothelial Cells (2025)
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Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2025)
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Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024)
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HIF-α signaling regulates the macrophage inflammatory response during <i>Leishmania major</i> infection (2024)
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One-pot method for preparing DNA, RNA, and protein for multiomics analysis (2024)
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Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells (2023)
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Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy (2023)
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Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy (2022)
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In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution (2022)
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Proteogenomics Reference Database Protocol v1 (2022)
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Proteogenomics Reference Database Protocol v1 (2022)
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Proteomic profiling of tear fluid as a promising non-invasive screening test for colon cancer (2022)
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Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy (2022)
Collaboration Network
Top Collaborators
Stephanie D. Byrum
Arkansas Children's Hospital
28 shared publications
In database
- proteoDA: a package for quantitative proteomics
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- PHF19 inhibition as a therapeutic target in multiple myeloma
Showing 5 of 28 shared publications
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
12 shared publications
In database
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- PHF19 inhibition as a therapeutic target in multiple myeloma
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
Showing 5 of 12 shared publications
Jordan T. Bird
University of Arkansas for Medical Sciences (US)
10 shared publications
- proteoDA: a package for quantitative proteomics
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- PHF19 inhibition as a therapeutic target in multiple myeloma
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
Showing 5 of 10 shared publications
Duah Alkam
Winthrop Rockefeller Foundation
10 shared publications
In database
- proteoDA: a package for quantitative proteomics
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- One-pot method for preparing DNA, RNA, and protein for multiomics analysis
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
- Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade
Showing 5 of 10 shared publications
Allen Gies
Winthrop Rockefeller Foundation
10 shared publications
In database
- proteoDA: a package for quantitative proteomics
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
- Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade
Showing 5 of 10 shared publications
Alan J. Tackett
9 shared publications
In database
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
Showing 5 of 9 shared publications
Hayden Roys
University of Arkansas for Medical Sciences
9 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 9 shared publications
Anne K. Bowlin
University of Arkansas for Medical Sciences
9 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 9 shared publications
Aaron J. Storey
8 shared publications
In database
- One-pot method for preparing DNA, RNA, and protein for multiomics analysis
- PTMViz: a tool for analyzing and visualizing histone post translational modification data
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Showing 5 of 8 shared publications
Gopinath Venugopal
University of Arkansas for Medical Sciences (US)
8 shared publications
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
Showing 5 of 8 shared publications
Tiffany Weinkopff
University of Arkansas for Medical Sciences
8 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during <i>Leishmania major</i> infection
Showing 5 of 8 shared publications
Lucy Fry
University of Arkansas for Medical Sciences
7 shared publications
In database
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during <i>Leishmania major</i> infection
- Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells
Showing 5 of 7 shared publications
Tung-Chin Chiang
7 shared publications
In database
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Showing 5 of 7 shared publications
Kanishka Manna
University of Arkansas for Medical Sciences
5 shared publications
In database
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
Michael S. Robeson
5 shared publications
In database
- proteoDA: a package for quantitative proteomics
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
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