Charity L. Washam
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Also affiliated: Arkansas Children's Hospital (2020); Emory University (2018–2019); University of California, Los Angeles (2022); University of Arkansas Medical Center (2010–2024); UCLA Jonsson Comprehensive Cancer Center (2022); Arkansas Children's Research Institute (2019–2026); Penn State Milton S. Hershey Medical Center (2013); Texas A&M University (2018–2019)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Charity L. Washam's research focuses on the application of multi-omics approaches to understand biological systems and disease mechanisms. Her work has involved the development of computational tools for quantitative proteomics, such as the proteoDA package. Washam has investigated cellular heterogeneity and transcriptomic profiling in response to infection, as seen in her studies on Leishmania major in mice. Her research also extends to cancer, where she has explored multi-omics data integration for understanding triple-negative breast cancer and proteomic profiling of tear fluid for non-invasive colon cancer screening. Additionally, her publications address exosomal microRNA and protein profiles in hepatocellular carcinoma and the therapeutic potential of PHF19 inhibition in multiple myeloma. Washam's scholarship metrics include an h-index of 14, 1,122 total citations, and 57 total publications. She has collaborated extensively with researchers at the University of Arkansas for Medical Sciences, including Stephanie D. Byrum, Duah Alkam, Allen Gies, and Jordan T. Bird.
Metrics
- h-index: 14
- Publications: 57
- Citations: 1,174
Selected Publications
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Abstract 6079: Resistance-specific proteogenomics in melanoma PDXs (2026)
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Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during L. major infection and promote host defense to infection (2026)
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Rescue of Angiopoietin‐2 Inhibits Proliferation of Lymphatic Malformation Endothelial Cells (2025)
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Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2025)
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Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024)
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HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2024)
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One-pot method for preparing DNA, RNA, and protein for multiomics analysis (2024)
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Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells (2023)
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Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy (2023)
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Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy (2022)
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In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution (2022)
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Proteogenomics Reference Database Protocol v1 (2022)
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Proteogenomics Reference Database Protocol v1 (2022)
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Proteomic profiling of tear fluid as a promising non-invasive screening test for colon cancer (2022)
Collaboration Network
Top Collaborators
- Multi-omics data integration considerations and study design for biological systems and disease
- Identification of PTHrP(12-48) as a Plasma Biomarker Associated with Breast Cancer Bone Metastasis
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
Showing 5 of 37 shared publications
- Identification of PTHrP(12-48) as a Plasma Biomarker Associated with Breast Cancer Bone Metastasis
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis
- Effect of Sulforaphane and 5-Aza-2’-Deoxycytidine on Melanoma Cell Growth
Showing 5 of 14 shared publications
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- PHF19 inhibition as a therapeutic target in multiple myeloma
Showing 5 of 14 shared publications
- Bone metastasis: mechanisms and therapeutic opportunities
- Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans
- Identification of PTHrP(12-48) as a Plasma Biomarker Associated with Breast Cancer Bone Metastasis
- PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan
- Proteomic Technologies for the Study of Osteosarcoma
Showing 5 of 10 shared publications
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Formula Diet Alters the Ileal Metagenome and Transcriptome at Weaning and during the Postweaning Period in a Porcine Model
- Neonatal Diet Impacts Circulatory miRNA Profile in a Porcine Model
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
Showing 5 of 10 shared publications
- Multi-omics data integration considerations and study design for biological systems and disease
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- PHF19 inhibition as a therapeutic target in multiple myeloma
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 9 shared publications
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 9 shared publications
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- One-pot method for preparing DNA, RNA, and protein for multiomics analysis
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
Showing 5 of 8 shared publications
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
Showing 5 of 8 shared publications
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Effect of Sulforaphane and 5-Aza-2’-Deoxycytidine on Melanoma Cell Growth
- One-pot method for preparing DNA, RNA, and protein for multiomics analysis
- PTMViz: a tool for analyzing and visualizing histone post translational modification data
Showing 5 of 7 shared publications
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 7 shared publications
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Effect of Sulforaphane and 5-Aza-2’-Deoxycytidine on Melanoma Cell Growth
- Abstract 1029: Epigenetic control of tumor-infiltrating lymphocyte metabolic-exhaustion
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
Showing 5 of 6 shared publications
- Multi-omics data integration considerations and study design for biological systems and disease
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
Showing 5 of 6 shared publications
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
Showing 5 of 6 shared publications
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells
Showing 5 of 6 shared publications
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