Alexander W. Alund
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Researcher
Also affiliated: Arkansas Children's Hospital (2016); United States Food and Drug Administration (2022–2025); Karolinska University Hospital (1984); Pfizer (United States) (2022–2023); Karolinska Institutet (1984); Swedish University of Agricultural Sciences (1984); Oklahoma Medical Research Foundation (2016); Project Oceanology (2023); Arkansas Children's Nutrition Center (2014–2018); Louisiana State University Health Sciences Center New Orleans (2016–2018); Texas A&M University (2018)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Alexander W. Alund's research investigates the mutagenicity and genotoxicity of various substances, including nanoparticles and ethanol. His work employs whole-genome sequencing in model organisms such as mouse lymphoma cells and *Caenorhabditis elegans* to detect mutations at ultralow frequencies. Alund has also explored the effects of prenatal exposure to ethanol, examining delayed developmental impacts. His research extends to the pharmacodynamics and metabolism of deuterated compounds, specifically buprenorphine, in rats, noting their resistance to metabolism into active metabolites. Alund has a h-index of 9, with 16 total publications and 190 citations. He has collaborated with researchers from the University of Arkansas for Medical Sciences, including Lisa K. Brents, Jeffery H. Moran, and Brian J. Parks, as well as Bohu Pan from the National Center for Toxicological Research, with multiple shared publications.
Metrics
- h-index: 9
- Publications: 16
- Citations: 201
Selected Publications
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Genotoxicity of nanoparticles evaluated using the <i>in vitro</i> micronucleus assay, a review of recent data <sup>§</sup> (2025)
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Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing (2023)
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Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022)
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Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells (2021)
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Skeletal toxicity resulting from exposure of growing male rats to coplanar PCB 126 is associated with disruption of calcium homeostasis and the GH-IGF-1 axis and direct effects on bone formation (2019)
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3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice (2019)
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In Utero Exposure to Norbuprenorphine, a Major Metabolite of Buprenorphine, Induces Fetal Opioid Dependence and Leads to Neonatal Opioid Withdrawal Syndrome (2019)
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2421 Development and validation of a translational rat model of neonatal abstinence syndrome (2018)
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Maternal obesity impairs skeletal development in adult offspring (2018)
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NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis (2018)
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Partial Protection by Dietary Antioxidants Against Ethanol‐Induced Osteopenia and Changes in Bone Morphology in Female Mice (2016)
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Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice (2016)
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Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice (2014)
Collaboration Network
Top Collaborators
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing
- Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing
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