Lu Huang
Assistant Professor
Microbiology & Immunology, College of Medicine
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Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Lu Huang's research focuses on understanding the complex interplay between host immune cells, particularly macrophages, and infectious pathogens, with a significant emphasis on Mycobacterium tuberculosis (Mtb).
Her work investigates how macrophage metabolism and ontogeny influence the growth and behavior of Mtb within the host. Huang has received substantial federal funding from the NIH/National Institute of Allergy and Infectious Diseases for projects examining macrophage metabolism in the context of diabetes and tuberculosis comorbidity, the ontogeny and metabolism of lung alveolar macrophages in tuberculosis, and the role of macrophage subsets in maintaining Mtb infection outcomes. She employs advanced techniques, including single-cell spatial-temporal analysis, to gain a detailed understanding of these interactions.
Huang's publications explore immunometabolism at the macrophage-pathogen interface, the impact of host immune activation on drug tolerance in Mtb, and the ontogenetic distinctions in host-pathogen interactions during infection. Her research network includes collaborators from the University of Arkansas for Medical Sciences, such as Lin‐Xi Li, J. Tucker Andrews, Shengyu Mu, and Zijing Zhang. With an h-index of 43 and over 6,200 citations across approximately 180 publications, her work is recognized as high-impact within the scientific community.
Metrics
- h-index: 43
- Publications: 180
- Citations: 6,201
Positions
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Assistant Professor 2026–presentBoston University Department of Virology, Immunology & Microbiology (VIM) ORCID
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Assistant ProfessorUniversity of Arkansas for Medical Sciences Microbiology & Immunology, College of Medicine Institutional directory
Selected Publications
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High-dimensional flow cytometry analysis reveals temporal dynamics of lung macrophages during Mycobacterium tuberculosis infection 2261143 (2026)
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β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025)
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The intracellular agent of Q fever, Coxiella burnetii , alters human alveolar macrophage metabolism and mitochondrial physiology (2025)
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Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics (2025)
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Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma (2025)
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Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer (2024)
Federal Grants 3 $1,166,326 total
Ontogeny and metabolism of lung alveolar macrophages in tuberculosis
Macrophage metabolism in diabetes and tuberculosis comorbidity
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- ECU sub to UAMS NIH/Nat. Inst. of Allergy & Infectious Diseases via East Carolina University Principal Investigator
- Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract US Department of Agriculture via University of Arkansas at Pine Bluff Principal Investigator
- Deciphering trained immuity in lung resident macrophages to combat tuberculosis American Lung Association Principal Investigator
- T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
Collaboration Network
Top Collaborators
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against Mycobacterium tuberculosis
Showing 5 of 8 shared publications
- Macrophages: an indispensable piece of ovarian health
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics
- Single-cell analysis of ovarian myeloid cells identifies aging associated changes in macrophages and signaling dynamics
- SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome
Showing 5 of 6 shared publications
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against Mycobacterium tuberculosis
Showing 5 of 6 shared publications
- Macrophages: an indispensable piece of ovarian health
- Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics
- Single-cell analysis of ovarian myeloid cells identifies aging associated changes in macrophages and signaling dynamics
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- The intracellular agent of Q fever, Coxiella burnetii , alters human alveolar macrophage metabolism and mitochondrial physiology
- β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against <i>Chlamydia</i>
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against <i>Chlamydia</i>
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against <i>Chlamydia</i>
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against <i>Chlamydia</i>
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics
- Single-cell analysis of ovarian myeloid cells identifies aging associated changes in macrophages and signaling dynamics
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
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