Lu Huang
Assistant Professor
Faculty Researcher
Microbiology & Immunology, College of Medicine
Upstream record may be merged OpenAlex, the source of these figures, lists 69 institutions in 8 countries for this author record — a pattern that usually means it combines several researchers with similar names. The totals above may include work by other people.
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Lu Huang's research focuses on understanding host-pathogen interactions, particularly in the context of tuberculosis infection, and investigating cellular signaling pathways that regulate metabolism. As a Principal Investigator at the University of Arkansas for Medical Sciences, Huang has received significant funding from the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases for projects examining macrophage metabolism in diabetes and tuberculosis comorbidity, the role of macrophage subsets in tuberculosis lesion biology, and the ontogeny and metabolism of lung alveolar macrophages in tuberculosis. These grants total over $1.3 million.
Huang's work utilizes advanced techniques, including single-cell analysis and lattice light sheet microscopy, to investigate complex biological processes. Publications from Huang's group have explored single-cell analysis of *M. tuberculosis* and macrophage lineages in the lung, PI3K signaling's role in metabolic reprogramming, and the structural dynamics of cellular processes like macropinosome formation. Collaborations within the University of Arkansas for Medical Sciences, including with Lin-Xi Li, J. Tucker Andrews, Shengyu Mu, and Zijing Zhang, have resulted in multiple shared publications, reflecting a cohesive research network.
With a h-index of 43 and over 6,000 citations across 180 publications, Huang is recognized as a highly cited researcher. The research portfolio spans fundamental biology, host-pathogen dynamics, and cellular metabolism, with a strong emphasis on immune cell function and its implications for infectious disease and metabolic health.
Metrics
- h-index: 43
- Publications: 180
- Citations: 6,201
Selected Publications
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High-dimensional flow cytometry analysis reveals temporal dynamics of lung macrophages during Mycobacterium tuberculosis infection 2261143 (2026)
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β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025)
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The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology (2025)
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Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics (2025)
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Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma (2025)
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Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer (2024)
Federal Grants 3 $1,377,213 total
Ontogeny and metabolism of lung alveolar macrophages in tuberculosis
Macrophage metabolism in diabetes and tuberculosis comorbidity
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- ECU sub to UAMS NIH/Nat. Inst. of Allergy & Infectious Diseases via East Carolina University Principal Investigator
- Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract US Department of Agriculture via University of Arkansas at Pine Bluff Principal Investigator
- Deciphering trained immuity in lung resident macrophages to combat tuberculosis American Lung Association Principal Investigator
- T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
Collaboration Network
Top Collaborators
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics
- SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics
- Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology
- Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
- Single cell analysis of <i>M. tuberculosis</i> phenotype and macrophage lineages in the infected lung
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