Mahmoud Kiaei
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Researcher
Also affiliated: NewYork–Presbyterian Hospital (2004–2011); Cornell University (2002–2013); Konkuk University (2006); University of Arkansas Medical Center (2016–2021); New York Hospital Queens (2004–2011); Oklahoma Medical Research Foundation (2006); Presbyterian Hospital (2004–2011); Center for Neurosciences (2015); Center for Translational Molecular Medicine (2016); BioVentures (United States) (2021); NewGen Therapeutics (United States) (2021–2023); Institute of Molecular Biology and Biophysics (2016); Arkansas Department of Agriculture (2023); Hannover Re (Germany) (2006); Icahn School of Medicine at Mount Sinai (2004)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mahmoud Kiaei's research focuses on understanding the molecular mechanisms underlying neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS). His work utilizes a combination of computational and experimental approaches to investigate the structural and functional consequences of genetic mutations associated with ALS. This includes in silico studies to predict how mutations in proteins like profilin-1 and TUBA4A affect protein structure and interactions with potential therapeutic agents, such as riluzole and edaravone.
Kiaei also employs biochemical techniques, including hydrogen/deuterium exchange mass spectrometry, to detect structural and conformational changes in mutant proteins in vitro and in vivo. His research has explored the potential of RNA as a biomarker for ALS and investigated the aggregation of mutant profilin-1. Collaborations with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville contribute to his ongoing investigations. Kiaei's publication record includes studies on disease models, protein structure, and the development of therapeutic strategies for neurological disorders.
Metrics
- h-index: 33
- Publications: 56
- Citations: 4,898
Selected Publications
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A systematic review of emerging technologies to enhance the treatment of ovarian cancer (2023)
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In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration (2023)
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Correction to: RNA as a Source of Biomarkers for Amyotrophic Lateral Sclerosis (2022)
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Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques (2021)
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RNA as a source of biomarkers for amyotrophic lateral sclerosis (2021)
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Mutant Profilin1 Aggregation in Amyotrophic Lateral Sclerosis: An in Vivo Biochemical Analysis (2021)
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In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis (2021)
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Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques (2021)
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Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis (2018)
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RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease (2018)
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ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation (2018)
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Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis (2018)
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Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease (2016)
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Profilin1 biology and its mutation, actin(g) in disease (2016)
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A retrospective review of the progress in amyotrophic lateral sclerosis drug discovery over the last decade and a look at the latest strategies (2015)
Collaboration Network
Top Collaborators
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques
- RNA as a source of biomarkers for amyotrophic lateral sclerosis
- Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques
- A systematic review of emerging technologies to enhance the treatment of ovarian cancer
- In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques
- Mutant Profilin1 Aggregation in Amyotrophic Lateral Sclerosis: An in Vivo Biochemical Analysis
- Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques
- In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques
- Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques
- Mutant Profilin1 Aggregation in Amyotrophic Lateral Sclerosis: An in Vivo Biochemical Analysis
- Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques
- In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques
- Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques
- Mutant Profilin1 Aggregation in Amyotrophic Lateral Sclerosis: An in Vivo Biochemical Analysis
- Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques
- Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- A systematic review of emerging technologies to enhance the treatment of ovarian cancer
- A systematic review of emerging technologies to enhance the treatment of ovarian cancer
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