Match tier
Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-10-05
M
Meenakshisundaram Balasubramaniam
Sourced from institutional research profiles (UAMS TRI or ARA).
High Impact
Assistant Professor
Also affiliated: United States Department of Veterans Affairs (2017); Central Arkansas Veterans Healthcare System (2016–2024); John L. McClellan Memorial Veterans Hospital (2016–2023); Bioingénierie, Tissus et Neuroplasticité (2023); All India Institute of Medical Sciences (2024)
23 h-index
55 pubs
1,329 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Meenakshisundaram Balasubramaniam's research focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease, and the development of potential therapeutic interventions. His work investigates protein aggregation, a hallmark of neurodegeneration, examining how misfolded proteins interact with cellular components like RNA and DNA. Balasubramaniam has explored the role of glial fibrillary acidic protein (GFAP) as a potential biomarker and therapeutic target for Alzheimer's disease, and has also studied the rescue of lysosomal autophagic failure in Alzheimer's disease models using small molecules.
His research also extends to other age-associated diseases and cellular processes. This includes investigating the role of mitochondria in aging and disease, and examining how conditions like myocardial infarction can induce endoplasmic reticulum stress and protein aggregation in both the heart and brain. Balasubramaniam leads a research group and has a significant publication record, with an h-index of 23 and over 1,200 citations. He collaborates with several researchers at the University of Arkansas for Medical Sciences, including Srinivas Ayyadevara and Robert J. Shmookler Reis.
Metrics
- h-index: 23
- Publications: 55
- Citations: 1,329
Positions
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Associate Professor 2025–presentUniversity of Arkansas for Medical Sciences Geriatrics ORCID
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Assistant Professor publications 2014–2026University of Arkansas for Medical Sciences Institutional directory
Selected Publications
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Abstract LB320: Inverse relationship between cancer and Alzheimer’s disease: Important interplay between autophagy and apoptosis signaling mechanisms (2026)
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Zolpidem restores sleep and decreases amyloid in a mouse model (2026)
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The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026)
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Zolpidem restores sleep and slows Alzheimer’s progression in a mouse model (2025)
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When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025)
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The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025)
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Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025)
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Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025)
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Mitochondria in aging and age-associated diseases (2025)
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Metabolomic Profiling and Machine Learning Models for Tumor Classification in Patients with Recurrent IDH-Wild-Type Glioblastoma: A Prospective Study (2024)
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Tools of Artificial Intelligence in the Improvement of Synaptic Impairment in Different Neurodegenerative Diseases (2024)
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Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024)
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Epidermal Growth Factor Receptor Inhibitors in Glioblastoma: Current Status and Future Possibilities (2024)
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Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024)
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Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- Early Events in Alzheimer Pathogenesis NIH
- Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH
- Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH/Nat. Inst. on Aging
Collaboration Network
Top Collaborators
Robert J. Shmookler Reis
University of Arkansas at Little Rock
32 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
- Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes
- Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
Showing 5 of 32 shared publications
Srinivas Ayyadevara
University of Arkansas for Medical Sciences
31 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
- Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes
- Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
Showing 5 of 31 shared publications
Akshatha Ganne
University of Arkansas for Medical Sciences
19 shared publications
In database
- Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
Showing 5 of 19 shared publications
Peter A. Crooks
University of Arkansas for Medical Sciences
10 shared publications
In database
- MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells
- Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
- A novel tetrazole analogue of resveratrol is a potent anticancer agent
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
Showing 5 of 10 shared publications
W. Sue T. Griffin
Central Arkansas Veterans Healthcare System
8 shared publications
In database
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease
Showing 5 of 8 shared publications
Narsimha Reddy Penthala
University of Arkansas for Medical Sciences
8 shared publications
In database
- Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
- A novel tetrazole analogue of resveratrol is a potent anticancer agent
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
Showing 5 of 8 shared publications
Nirjal Mainali
University of Arkansas at Little Rock
8 shared publications
In database
- Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
- Mitochondria in aging and age-associated diseases
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Showing 5 of 8 shared publications
Steven W. Barger
Central Arkansas Veterans Healthcare System
7 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
Showing 5 of 7 shared publications
Sonu Pahal
University of Arkansas at Little Rock
6 shared publications
In database
- Mitochondria in aging and age-associated diseases
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
- Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets
- Tools of Artificial Intelligence in the Improvement of Synaptic Impairment in Different Neurodegenerative Diseases
- Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology
Showing 5 of 6 shared publications
Ramani Alla
Central Arkansas Veterans Healthcare System
5 shared publications
In database
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
- Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- PIP3-binding proteins promote age-dependent protein aggregation and limit survival in<i>C. elegans</i>
Samuel Kakraba
University of Arkansas for Medical Sciences (US)
5 shared publications
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Aggregate Interactome Based on Protein-Crosslinking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
Sue Griffin
Central Arkansas Veterans Healthcare System
5 shared publications
In database
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- P2‐181: IL‐1β INFLUENCES AUTOPHAGY BY MEDIATING UPREGULATION OF PARKIN AND PARKIN NEDDYLATION IN CELL CULTURE AND ANIMAL MODELS, AND MIMICS THE PATTERN SEEN IN AD BRAIN
- Aggregate Interactome Based on Protein-Crosslinking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease
Paul A. Parcon
University of Arkansas for Medical Sciences (US)
4 shared publications
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
- P2‐181: IL‐1β INFLUENCES AUTOPHAGY BY MEDIATING UPREGULATION OF PARKIN AND PARKIN NEDDYLATION IN CELL CULTURE AND ANIMAL MODELS, AND MIMICS THE PATTERN SEEN IN AD BRAIN
Ramani Atluri
Central Arkansas Veterans Healthcare System
4 shared publications
In database
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Narasimhappagari Jagadeesh
University of Arkansas for Medical Sciences
4 shared publications
In database
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone
- Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents
- When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis
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