Makenzie A Tharpe

This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.

Researcher

University of Arkansas

Also affiliated: Clemson University (2024)

Graduate Student Researcher

1 h-index 3 pubs 1 cited

Research Areas

OverviewAI-generated summary

Makenzie A Tharpe's research focuses on the impact of nutrient deficiencies on cellular metabolism, particularly within muscle cells. In recent work, Tharpe investigated how iron depletion affects energy metabolism in C2C12 myoblast cells, observing impairments in mitochondrial complex I activity and specific protein level reductions. Further studies explored the consequences of folate deficiency and the loss of the SHMT2 enzyme, noting impacts on protein levels associated with oxidative phosphorylation, folate transport, and mitochondrial dynamics in the same cell line. These studies contribute to understanding the molecular mechanisms underlying metabolic dysfunction under specific nutritional stress conditions. Tharpe collaborates with Joanna Fiddler and Abigail L Zirbel at the University of Arkansas at Fayetteville, with whom they have co-authored three publications.

Metrics

h-index: 1
Publications: 3
Citations: 1

Selected Publications

Loss of SHMT2 and Folate Deficiency Impair Protein Levels Involved in Oxidative Phosphorylation, Folate Transport, and Mitochondrial Dynamics in Mouse C2C12 Myoblast Cells (2025)

Current Developments in Nutrition DOI OpenAlex
Marginal Iron Depletion Impairs Mitochondrial Complex I Activity and Reduces NDUFB8 and ISCU Protein Levels in Mouse C2C12 Myoblast Cells (2025)

Current Developments in Nutrition DOI OpenAlex