M
Marcelo Bigarella Institution-verified
Sourced from institutional research profiles (UAMS TRI or ARA).
Researcher
faculty
2 h-index
18 pubs
13 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Marcelo Bigarella's research focuses on the molecular mechanisms and diagnostic approaches for prostate cancer. He has investigated the role of specific enzymes, such as p300/CBP and SIRT2, in the acetylation of histones within circulating tumor cells, particularly in the context of castration-resistant prostate cancer (CRPC). Bigarella has also explored the impact of 5α-reductase inhibitors on prostate magnetic resonance imaging (MRI) characteristics and their role in cancer detection. His work includes evaluating the utility of PSA kinetics and advanced imaging techniques like 18F-DCFPyL PSMA PET/MRI for improving the detection of clinically significant prostate cancer, especially in men undergoing active surveillance. He has published 18 works with a total of 2 citations and an h-index of 2. His recent collaborations include work with Jaskirat Sethi, Sunny Singh, Yusra B. Medik, and Sehrish Sardar at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 2
- Publications: 18
- Citations: 13
Selected Publications
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Stem Cell Origin of Cancer: Biological Principles and Clinical Strategies for Chemoprevention and Maintenance Therapy in Cancer Care (2025)
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Multidisciplinary management of nonmetastatic locally advanced prostate cancer (T3-4N0M0) (2025)
Collaboration Network
Top Collaborators
David F. Jarrard
University of Wisconsin Carbone Cancer Center (US)
8 shared publications
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Prostate zonal impact of 5α‐reductase inhibitors on multiparametric <scp>MRI</scp> characteristics and detection of prostate cancer
- Abstract B051: Alterations in SIRT2-H3K18Ac identify increased P300 activity in circulating tumor cells from patients with CRPC
- Development and initial clinical testing of a multiplex assay evaluating histone modifier p300 acetylation in prostate cancer circulating tumor cells.
- IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY OF mpMRI IN LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
Showing 5 of 8 shared publications
Shane A. Wells
5 shared publications
- IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY OF mpMRI IN LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- MP31-05 5-ALPHA REDUCTASE INHIBITOR USE REDUCES THE CLINICAL PERFORMANCE OF MULTIPARAMETRIC MRI IN THE DETECTION OF CLINICALLY SIGNIFICANT PROSTATE CANCER
- MP18-18 IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY of MPMRI IN MEN WITH LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- IP21-33 ADDITION OF 18F-DCFPYL PSMA PET/MRI IMPROVES ACCURACY TO DETECT CLINICALLY SIGNIFICANT PROSTATE CANCER IN MEN ON ACTIVE SURVEILLANCE: FINAL RESULTS FROM PHASE II DIAGNOSTIC TRIAL
- 18F-DCFPyL PSMA PET/MRI improves detection of clinically significant prostate cancer in men on active surveillance: Results from a Phase II trial
John M. Denu
4 shared publications
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Abstract B051: Alterations in SIRT2-H3K18Ac identify increased P300 activity in circulating tumor cells from patients with CRPC
- Development and initial clinical testing of a multiplex assay evaluating histone modifier p300 acetylation in prostate cancer circulating tumor cells.
- PD35-07 IDENTIFYING AND TARGETING UPREGULATED HISTONE MODIFYING ENZYMES INVOLVED IN PROSTATE CANCER CELL SURVIVAL AFTER ANDROGEN DEPRIVATION THERAPY
Edward R. Lawrence
4 shared publications
- IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY OF mpMRI IN LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- MP18-18 IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY of MPMRI IN MEN WITH LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- IP21-33 ADDITION OF 18F-DCFPYL PSMA PET/MRI IMPROVES ACCURACY TO DETECT CLINICALLY SIGNIFICANT PROSTATE CANCER IN MEN ON ACTIVE SURVEILLANCE: FINAL RESULTS FROM PHASE II DIAGNOSTIC TRIAL
- 18F-DCFPyL PSMA PET/MRI improves detection of clinically significant prostate cancer in men on active surveillance: Results from a Phase II trial
Steve Cho
4 shared publications
- IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY OF mpMRI IN LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- MP18-18 IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY of MPMRI IN MEN WITH LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- IP21-33 ADDITION OF 18F-DCFPYL PSMA PET/MRI IMPROVES ACCURACY TO DETECT CLINICALLY SIGNIFICANT PROSTATE CANCER IN MEN ON ACTIVE SURVEILLANCE: FINAL RESULTS FROM PHASE II DIAGNOSTIC TRIAL
- 18F-DCFPyL PSMA PET/MRI improves detection of clinically significant prostate cancer in men on active surveillance: Results from a Phase II trial
Mikolaj Filon
University of Wisconsin–Madison (US)
3 shared publications
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Abstract B051: Alterations in SIRT2-H3K18Ac identify increased P300 activity in circulating tumor cells from patients with CRPC
- Development and initial clinical testing of a multiplex assay evaluating histone modifier p300 acetylation in prostate cancer circulating tumor cells.
Bing Yang
University of Wisconsin–Madison (US)
3 shared publications
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Abstract B051: Alterations in SIRT2-H3K18Ac identify increased P300 activity in circulating tumor cells from patients with CRPC
- Development and initial clinical testing of a multiplex assay evaluating histone modifier p300 acetylation in prostate cancer circulating tumor cells.
Jennifer L. Schehr
University of Wisconsin–Madison (US)
3 shared publications
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Abstract B051: Alterations in SIRT2-H3K18Ac identify increased P300 activity in circulating tumor cells from patients with CRPC
- Development and initial clinical testing of a multiplex assay evaluating histone modifier p300 acetylation in prostate cancer circulating tumor cells.
Anupama Singh
University of Wisconsin–Madison (US)
3 shared publications
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Abstract B051: Alterations in SIRT2-H3K18Ac identify increased P300 activity in circulating tumor cells from patients with CRPC
- Development and initial clinical testing of a multiplex assay evaluating histone modifier p300 acetylation in prostate cancer circulating tumor cells.
Joshua M. Lang
University of Wisconsin–Madison (US)
3 shared publications
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Abstract B051: Alterations in SIRT2-H3K18Ac identify increased P300 activity in circulating tumor cells from patients with CRPC
- Development and initial clinical testing of a multiplex assay evaluating histone modifier p300 acetylation in prostate cancer circulating tumor cells.
Abigail M. Wiedmer
3 shared publications
- IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY OF mpMRI IN LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- MP18-18 IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY of MPMRI IN MEN WITH LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- IP21-33 ADDITION OF 18F-DCFPYL PSMA PET/MRI IMPROVES ACCURACY TO DETECT CLINICALLY SIGNIFICANT PROSTATE CANCER IN MEN ON ACTIVE SURVEILLANCE: FINAL RESULTS FROM PHASE II DIAGNOSTIC TRIAL
Tudor Borza
3 shared publications
- IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY OF mpMRI IN LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
- MP31-05 5-ALPHA REDUCTASE INHIBITOR USE REDUCES THE CLINICAL PERFORMANCE OF MULTIPARAMETRIC MRI IN THE DETECTION OF CLINICALLY SIGNIFICANT PROSTATE CANCER
- MP18-18 IMPACT OF 18F-DCFPYL PSMA PET ON ACCURACY of MPMRI IN MEN WITH LOW AND INTERMEDIATE RISK PROSTATE CANCER: INTERIM ANALYSIS OF A PHASE II DIAGNOSTIC TRIAL
David Jarrard
3 shared publications
- Multidisciplinary management of nonmetastatic locally advanced prostate cancer (T3-4N0M0)
- IP21-33 ADDITION OF 18F-DCFPYL PSMA PET/MRI IMPROVES ACCURACY TO DETECT CLINICALLY SIGNIFICANT PROSTATE CANCER IN MEN ON ACTIVE SURVEILLANCE: FINAL RESULTS FROM PHASE II DIAGNOSTIC TRIAL
- 18F-DCFPyL PSMA PET/MRI improves detection of clinically significant prostate cancer in men on active surveillance: Results from a Phase II trial
Roberto Iglesias Lopes
Universidade de São Paulo (BR)
2 shared publications
- Bilateral external iliac artery pseudoaneurysms causing urinary obstruction and acute renal failure
- BILATERAL EXTERNAL ILIAC PSEUDOANEURYSMS CAUSING URINARY OBSTRUCTION AND ACUTE RENAL FAILURE
Guilherme Gentile
Universidade de São Paulo (BR)
2 shared publications
- Bilateral external iliac artery pseudoaneurysms causing urinary obstruction and acute renal failure
- BILATERAL EXTERNAL ILIAC PSEUDOANEURYSMS CAUSING URINARY OBSTRUCTION AND ACUTE RENAL FAILURE
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