Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
M
Matthew Brownd
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
Researcher
Also affiliated: John Brown University (2018–2019)
Faculty Researcher
1 h-index
11 pubs
12 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Matthew Brownd's research focuses on understanding the molecular mechanisms of biological transporters, particularly ATP-binding cassette (ABC) transporters. He investigates their conformational cycles and the role of lipid bilayers and nucleotide binding in their function. His work utilizes computational methods, including molecular dynamics simulations and free-energy perturbation calculations, to explore protein binding affinities and conformational dynamics.
Recent publications from Brownd's group have examined the conformational cycle of a protease-containing ABC transporter in lipid nanodiscs, revealing insights into cargo-protein coupling. Other studies have investigated the dynamics of ABC exporters like PCAT1 and P-glycoprotein, as well as the binding activity within HCN channel subfamilies and the conformational dynamics of intrinsically disordered localization sequences. His collaborators at the University of Arkansas at Fayetteville include Adithya Polasa, Mahmoud Moradi, Mortaza Derakhshani-Molayousefi, and Ahmed Shubbar.
Metrics
- h-index: 1
- Publications: 11
- Citations: 12
Selected Publications
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Deciphering Chemomechanical Couplings in Proteins Using Molecular Dynamics and Enhanced Sampling Techniques (2026)Journal of the Arkansas Academy of Science OpenAlex
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An Investigation of the Conformational Dynamics of ABC Exporter PCAT1 using Microsecond-Level MD Simulations (2026)
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Characterizing the Conformational Dynamics of an Intrinsically Disordered Localization Sequence (2026)
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Predicting Binding Affinities for the Binding Domain of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Isoforms Using Free-Energy Perturbation (2026)
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BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations (2025)
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Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling (2024)
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Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling (2024)
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Comparison of cyclic AMP binding activity within HCN channel subfamily using atomistic molecular dynamics simulations of isolated cyclic nucleotide binding domains (2023)
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Using molecular dynamics simulations to characterize the structural/conformational effect of amino acid substitutions at the second position of the intrinsically disordered mitochondrial localization peptide (MLP) (2022)
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Investigation of Cyclic AMP Binding Interactions with Isolated Cyclic Nucleotide Binding Domain of HCN1 Channel using Atomistic Molecular Dynamics Simulations at Microsecond Timescale (2021)
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Novel F13,F15 Gramicidin Subunits Predicted to Cross Bilayer Membranes and form Ion Channels (2019)
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Gramicidin Subunits that Cross Membranes and form Ion Channels (2018)
Collaboration Network
Top Collaborators
Mahmoud Moradi
University of Arkansas at Fayetteville
9 shared publications
In database
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
- Investigation of Cyclic AMP Binding Interactions with Isolated Cyclic Nucleotide Binding Domain of HCN1 Channel using Atomistic Molecular Dynamics Simulations at Microsecond Timescale
- Using molecular dynamics simulations to characterize the structural/conformational effect of amino acid substitutions at the second position of the intrinsically disordered mitochondrial localization peptide (MLP)
- Comparison of cyclic AMP binding activity within HCN channel subfamily using atomistic molecular dynamics simulations of isolated cyclic nucleotide binding domains
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
Showing 5 of 9 shared publications
Adithya Polasa
University of Arkansas at Fayetteville
3 shared publications
In database
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
- Investigation of Cyclic AMP Binding Interactions with Isolated Cyclic Nucleotide Binding Domain of HCN1 Channel using Atomistic Molecular Dynamics Simulations at Microsecond Timescale
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
Hassane S. Mchaourab
Vanderbilt University (US)
2 shared publications
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
Ruojing Zhang
Vanderbilt University (US)
2 shared publications
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
Kevin L. Jagessar
Vanderbilt University (US)
2 shared publications
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
Richard A. Stein
Vanderbilt University (US)
2 shared publications
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
Erkan Karakaş
Vanderbilt University (US)
2 shared publications
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
- Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling
Samuel Mwatha
University of Arkansas at Fayetteville
1 shared publication
In database
- BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations
Ahmed Shubbar
University of Arkansas at Fayetteville
1 shared publication
In database
- BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations
Mortaza Derakhshani-Molayousefi
University of Arkansas at Fayetteville
1 shared publication
In database
- BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations
Stephanie Sauve
University of Arkansas at Fayetteville
1 shared publication
In database
- Predicting Binding Affinities for the Binding Domain of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Isoforms Using Free-Energy Perturbation
Hope Woods
University of Arkansas at Fayetteville
1 shared publication
In database
- Predicting Binding Affinities for the Binding Domain of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Isoforms Using Free-Energy Perturbation
Parth Chaturvedi
University of Arkansas at Fayetteville
1 shared publication
In database
- Characterizing the Conformational Dynamics of an Intrinsically Disordered Localization Sequence
Ashkan Fakharzadeh
University of Illinois Urbana-Champaign (US)
1 shared publication
- Characterizing the Conformational Dynamics of an Intrinsically Disordered Localization Sequence
Ehsaneh Khodadadi
University of Arkansas at Fayetteville
1 shared publication
In database
- An Investigation of the Conformational Dynamics of ABC Exporter PCAT1 using Microsecond-Level MD Simulations
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