Biography and Research Information
OverviewAI-generated summary
Samuel Mwatha's research investigates the molecular mechanisms underlying multidrug resistance in biological systems. His work utilizes molecular dynamics and free energy perturbation simulations to explore how lipids and nucleotides interact with and modulate the function of transport proteins, specifically multidrug resistance protein 1 (P-gp) and multidrug resistance-associated protein 1 (MRP1). Mwatha has published three papers on these topics, with recent work in 2025 focusing on lipid-protein interactions and nucleotide binding in P-glycoprotein. He has collaborated with researchers at the University of Arkansas at Fayetteville, including Mortaza Derakhshani-Molayousefi and Ahmed Shubbar, on shared publications.
Metrics
- Publications: 3
Selected Publications
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BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations (2025)
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Molecular dynamics simulations for atomic-level characterization of lipid interactions with the bovine multidrug resistance-associated protein 1 (bMRP1) (2024)
Collaboration Network
Top Collaborators
Mahmoud Moradi
University of Arkansas at Fayetteville
3 shared publications
In database
- Molecular dynamics simulations for atomic-level characterization of lipid interactions with the bovine multidrug resistance-associated protein 1 (bMRP1)
- BPS2025 - Molecular dynamics insights into lipid and nucleotide modulation of P-glycoprotein transport cycle
- BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations
Ahmed Shubbar
University of Arkansas at Fayetteville
2 shared publications
In database
- BPS2025 - Molecular dynamics insights into lipid and nucleotide modulation of P-glycoprotein transport cycle
- BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations
Mortaza Derakhshani-Molayousefi
University of Arkansas at Fayetteville
2 shared publications
In database
- BPS2025 - Molecular dynamics insights into lipid and nucleotide modulation of P-glycoprotein transport cycle
- BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations
Matthew Brownd
1 shared publication
- BPS2025 - Molecular dynamics insights into lipid and nucleotide modulation of P-glycoprotein transport cycle
Mathew Brownd
University of Arkansas at Fayetteville
1 shared publication
In database
- BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations
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