Samuel Mwatha

Researcher

University of Arkansas at Fayetteville

grad_student

3 pubs

Research Areas

Protein Structure and Dynamics Drug Transport and Resistance Mechanisms Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks

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OverviewAI-generated summary

Samuel Mwatha's research focuses on the molecular mechanisms underlying multidrug resistance in proteins, specifically P-glycoprotein and multidrug resistance-associated protein 1 (MRP1). His work utilizes molecular dynamics and free energy perturbation simulations to investigate how lipid-protein interactions and nucleotide binding influence the function of these transport proteins. Recent publications explore the atomic-level characterization of lipid interactions with bovine MRP1 and provide insights into how lipids and nucleotides modulate the P-glycoprotein transport cycle. Mwatha has co-authored publications with Mortaza Derakhshani-Molayousefi and Ahmed Shubbar at the University of Arkansas at Fayetteville.

Metrics

  • Publications: 3

Selected Publications

  • BPS2025 - Exploring lipid-protein interactions and nucleotide binding in multidrug resistance protein 1: Insights from molecular dynamics and free energy perturbation simulations (2025) DOI
  • Molecular dynamics simulations for atomic-level characterization of lipid interactions with the bovine multidrug resistance-associated protein 1 (bMRP1) (2024) DOI

Collaborators

Researchers in the database who share publications

Mortaza Derakhshani-Molayousefi University of Arkansas at Fayetteville 2 shared publications Ahmed Shubbar University of Arkansas at Fayetteville 2 shared publications

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