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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-05
Nancy J. Rusch
High Impact
Distinguished Professor
Also affiliated: Broad Institute (2014); Université de Tours (2002); University of Vermont (2010); University of Iowa (1985–2008); Mayo Clinic (1983–1988); University of Nevada, Reno (1987); The University of Texas MD Anderson Cancer Center (2019); University of Kansas (2014); University of Antwerp (2008); Inserm (2002); The University of Queensland (2012); Oregon Health & Science University (1989); Baylor College of Medicine (2007); Universität Innsbruck (1998); University of Washington (2012); Medical College of Wisconsin (1988–2005); Max Delbrück Center (2014); University of Arkansas Medical Center (2006–2024); Providence Portland Medical Center (1988–1989); University of Rochester Medicine (2012); The University of Kansas Cancer Center (2014); Leibniz-Forschungsinstitut für Molekulare Pharmakologie (2014); Milwaukee VA Medical Center (1996–2004); University of Kansas Medical Center (2014); Weill Cornell Medical College in Qatar (2010); University of Virginia (2012); University of Rochester (2012); The University of Texas Medical Branch at Galveston (2019); University of Cincinnati (1987); Charité - Universitätsmedizin Berlin (2014)
College of Medicine
42 h-index
196 pubs
5,115 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Nancy J. Rusch, a Distinguished Professor at the University of Arkansas for Medical Sciences' College of Medicine, investigates the physiological mechanisms underlying vascular function and dysfunction, with a particular focus on hypertension. Her research group studies the role of ion channels, such as voltage-gated potassium and calcium channels, in regulating vascular smooth muscle tone. This work has explored how altered channel expression and function contribute to the development and maintenance of high blood pressure. Her publications include investigations into the upregulation of L-type calcium channels in arteries of spontaneously hypertensive rats and the impact of high glucose on potassium channel currents in coronary arteries.
Rusch's research also examines the contribution of receptor signaling pathways, like the Angiotensin II Type 1a receptor, to vascular responses such as myogenic tone. She has published extensively on these topics, with her work cited nearly 5,000 times and an h-index of 42. She has collaborated with researchers including Abdelrahman Y. Fouda, Shengyu Mu, Amanda J. Stolarz, and Esraa Shosha, all from the University of Arkansas for Medical Sciences, on multiple shared publications. Her active lab website and leadership of a research group further indicate her ongoing contributions to the field.
Metrics
- h-index: 42
- Publications: 196
- Citations: 5,115
Positions
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Distinguished Professor publications 2005–2026University of Arkansas for Medical Sciences College of Medicine Institutional directory
Selected Publications
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Heat shock protein 72 is a druggable target during cold storage to improve graft outcome after kidney transplantation (2026)
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CD5L promotes efferocytosis and resolution of retinal ischemic injury (2026)
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Nanoencapsulated gamma-oryzanol enhances fibroblast proliferation, migration, and reduces oxidative stress in H2O2-induced cellular aging model (2025)
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Smooth muscle excitability (2025)
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HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis (2025)
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The role of efferocytosis in ischemic stroke and insights from retinopathy (2025)
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Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats (2024)
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)
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The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β‐catenin Signaling via Epigenetic Dysregulation that Enhances Sp1‐β catenin‐p300 Interactions in Hepatocellular Carcinoma (2024)
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SS-31 Attenuates Doxorubicin-induced Cardiomyoblast H9C2 Cell Senescence (2024)
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Abstract 3011: The loss of an orphan nuclear receptor NR2E3 augments Wnt/β-Catenin signaling via epigenetic dysregulation that links to the Sp1-β catenin-p300 interactions in hepatocellular carcinoma (2024)
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Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions (2024)
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The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury (2023)
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PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging (2023)
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Mitochondrial proton leak in cardiac aging (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- MicroRNA to decrease vascular CaV1.2 in hypertension NIH Co-Investigator
- AHA-Vascular TRPC3 Channels as Antihypertensive Targets American Heart Association (SouthWest Affiliate) Principal Investigator
- Beta adrenergic receptor-mediated vasodilation of cerebral collateral arteries- Resubmission- Resubmission American Heart Association Principal Investigator
- T32 Campus Match funding Account UAMS College of Medicine Principal Investigator
- Pharmacology Dept GEF Account UAMS College of Medicine Principal Investigator
- Long-term Antihypertensive Therapy by Delivery of the BK Channel Gene to VSMCs NIH Principal Investigator
- Role of mitoBK channels in rat renal cold preservation American Heart Association (SouthWest Affiliate) Principal Investigator
- Role of Cerebrovascular K+ Channels in Hypertension NIH Principal Investigator
- Vascular Calcium Channel Expression in Hypertension NIH Principal Investigator
- PSD95 scaffolding of vascular K+ channels in hypertension NIH Co-Investigator
- Expanding Translational Research in Arkansas NIH Co-Investigator
- Doxorubicin suppression of lymphatic function and therapeutic reversal NIH Principal Investigator
- REGULATION OF VENOUS MUSCLE K+ CHANNELS NIH Principal Investigator
- J. NRSA Training NIH Principal Investigator
- TROPHIC EFFECT OF SYMPATHETIC NERVES ON ARTERIAL MUSCLE NIH Principal Investigator
- Calcium Channels in Neonatal Pulmonary Hypertension NIH Principal Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Dr. Rusch Start Up Account UAMS College of Medicine Principal Investigator
- VASCULAR MUSCLE CALCIUM CURRENTS IN HYPERTENSION NIH Principal Investigator
- Connect Arkansas Research Scholars (CARS) Program University of Arkansas at Pine Bluff Principal Investigator
Collaboration Network
Top Collaborators
Sung W. Rhee
Kaiser Permanente
29 shared publications
In database
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Protein Kinase A–Phosphorylated K V 1 Channels in PSD95 Signaling Complex Contribute to the Resting Membrane Potential and Diameter of Cerebral Arteries
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- Loss of cerebrovascularShaker-type K+channels: a shared vasodilator defect of genetic and renal hypertensive rats
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
Showing 5 of 29 shared publications
Amanda J. Stolarz
University of Arkansas for Medical Sciences
17 shared publications
In database
- PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging
- Gender Differences in Cardiovascular Drugs
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
Showing 5 of 17 shared publications
Terry W. Fletcher
University of Arkansas for Medical Sciences
14 shared publications
In database
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- Serotonin uptake rates in platelets from angiotensin II-induced hypertensive mice
- High‐speed microscopy for in vivo monitoring of lymph dynamics
- Characterization of a surgical model of lymphatic insufficiency in the rat mesentery
Showing 5 of 14 shared publications
Sujay V. Kharade
University of Arkansas for Medical Sciences (US)
13 shared publications
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
- BK Channels in Rat and Human Pulmonary Smooth Muscle Cells are BKα‐β1 Functional Complexes Lacking the Oxygen‐Sensitive Stress Axis Regulated Exon Insert
- The β3 subunit: a key regulator of vascular calcium channel expression (1057.10)
- Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells
Showing 5 of 13 shared publications
Shengyu Mu
University of Arkansas for Medical Sciences
12 shared publications
In database
- Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies
- Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Showing 5 of 12 shared publications
Biny K. Joseph
University of Arkansas for Medical Sciences (US)
11 shared publications
- Loss of cerebrovascularShaker-type K+channels: a shared vasodilator defect of genetic and renal hypertensive rats
- Postsynaptic density‐95 scaffolding of Shaker‐type K+ channels in smooth muscle cells regulates the diameter of cerebral arteries
- Starring TREK-1
- 17β‐estradiol reduces Cav1.2 channel abundance and attenuates Ca2+‐dependent contractions in coronary arteries
- β1 adrenergic receptor‐initiated dilation in rat cerebral arteries is mediated by Shaker ‐type K V 1 channels and is attenuated in angiotensin II‐induced hypertension
Showing 5 of 11 shared publications
Asif R. Pathan
University of Arkansas for Medical Sciences (US)
10 shared publications
- Inositol 1,4,5-Trisphosphate (IP3) Receptor Up-regulation in Hypertension Is Associated with Sensitization of Ca2+ Release and Vascular Smooth Muscle Contractility
- Postsynaptic density‐95 scaffolding of Shaker‐type K+ channels in smooth muscle cells regulates the diameter of cerebral arteries
- Two-Pore Domain K + Channels
- Stretch‐activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries (1067.8)
- Doxorubicin Inhibition of Lymphatic Function is Mediated by Ryanodine Receptors and Prevented by Dantrolene
Showing 5 of 10 shared publications
Keshari Thakali
University of Arkansas for Medical Sciences
10 shared publications
In database
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
- Postsynaptic density‐95 scaffolding of Shaker‐type K+ channels in smooth muscle cells regulates the diameter of cerebral arteries
- 17β‐estradiol reduces Cav1.2 channel abundance and attenuates Ca2+‐dependent contractions in coronary arteries
- Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells
Showing 5 of 10 shared publications
Ekaterina I. Galanzha
University of Arkansas for Medical Sciences
7 shared publications
In database
- Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- High‐speed microscopy for in vivo monitoring of lymph dynamics
- Characterization of a surgical model of lymphatic insufficiency in the rat mesentery
- Doxorubicin Inhibition of Lymphatic Function is Mediated by Ryanodine Receptors and Prevented by Dantrolene
Showing 5 of 7 shared publications
Neil D. Detweiler
Goshen College (US)
7 shared publications
- Furegrelate, a Thromboxane Synthase Inhibitor, Blunts the Development of Pulmonary Arterial Hypertension in Neonatal Piglets
- BK Channels in Rat and Human Pulmonary Smooth Muscle Cells are BKα‐β1 Functional Complexes Lacking the Oxygen‐Sensitive Stress Axis Regulated Exon Insert
- Properties of the high‐conductance Ca 2+ ‐activated K + (BK) channel in pulmonary arterial smooth muscle cells (847.3)
- Targeting the high‐conductance Ca2+‐activated K+ (BK) channel as vasodilator therapy for pulmonary hypertension
- Detecting thromboxane signaling abnormalities in experimental models of pulmonary arterial hypertension
Showing 5 of 7 shared publications
Abdelrahman Y. Fouda
Cairo University
7 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- The role of efferocytosis in ischemic stroke and insights from retinopathy
Showing 5 of 7 shared publications
Joseph R. Stimers
University of Arkansas for Medical Sciences (US)
6 shared publications
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
- Overexpression of the Large-Conductance, Ca2+-Activated K+ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes
- Doxorubicin Inhibition of Lymphatic Function is Mediated by Ryanodine Receptors and Prevented by Dantrolene
- Doxorubicin inhibits lymphatic function in vitro and in vivo (655.1)
- L‐type Ca2+ channels are expressed but not activated by KCl in rat small mesenteric veins
Showing 5 of 6 shared publications
Vladimir P. Zharov
University of Arkansas for Medical Sciences
6 shared publications
In database
- Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- High‐speed microscopy for in vivo monitoring of lymph dynamics
- Characterization of a surgical model of lymphatic insufficiency in the rat mesentery
- Doxorubicin Inhibition of Lymphatic Function is Mediated by Ryanodine Receptors and Prevented by Dantrolene
Showing 5 of 6 shared publications
Swapnil K. Sonkusare
University of Arkansas for Medical Sciences (US)
6 shared publications
- Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implications
- The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice
- Intracellular Ca2+Silences L-Type Ca2+Channels in Mesenteric Veins
- L‐type Ca2+ channels are expressed but not activated by KCl in rat small mesenteric veins
- Vascular α 1C and β3 subunits of L‐type calcium channels are coordinately upregulated in the mesenteric arteries of hypertensive C57BL6 mice
Showing 5 of 6 shared publications
Mustafa Sarimollaoglu
University of Arkansas for Medical Sciences
6 shared publications
In database
- Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo
- Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
- KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
- High‐speed microscopy for in vivo monitoring of lymph dynamics
- Characterization of a surgical model of lymphatic insufficiency in the rat mesentery
Showing 5 of 6 shared publications
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