R L Jilka
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Also affiliated: United States Department of Veterans Affairs (1985–1989); Eli Lilly (United States) (1992); Kansas State University (1972); Washington University in St. Louis (1975–1983); University of Arkansas Medical Center (1998–2013); Veterans Health Administration (1989); Central Arkansas Veterans Healthcare System (2001–2013); Richard L. Roudebush VA Medical Center (1992–1994); University of Kansas Medical Center (1982–1990); Kansas City VA Medical Center (1982–1989); Indiana University Indianapolis (1994); Indiana University School of Medicine (1993); Saint Louis University (1975); Indiana University (1992)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
R L Jilka's research has focused on the cellular and molecular mechanisms of bone remodeling, particularly in relation to osteoporosis and the effects of hormones and cytokines. Studies have investigated the roles of osteoblasts, osteoclasts, and bone marrow-derived stromal cells in bone metabolism. Specific areas of investigation include the impact of glucocorticoids on osteoblastogenesis and apoptosis, and the influence of parathyroid hormone on osteocyte sclerostin expression in mice. The research also explores the mechanisms by which sex steroids, such as 17 beta-estradiol and androgens, exert their effects on bone, including inhibition of interleukin-6 production and regulation of osteoclastogenesis through androgen receptors.
Further work has examined the role of cytokines like interleukin-6 and interleukin-11 in osteoclast development and bone remodeling. Investigations have included the use of animal models, specifically mice, to study these processes. The research has contributed to understanding the pathophysiology of osteoporosis and potential therapeutic targets. The researcher's work is supported by a significant publication record, with 42 publications and over 9,800 citations, reflecting an h-index of 27.
Metrics
- h-index: 27
- Publications: 42
- Citations: 9,841
Selected Publications
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The Relevance of Mouse Models for Investigating Age-Related Bone Loss in Humans (2013)
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Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis (2005)
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Inhibin Suppresses and Activin Stimulates Osteoblastogenesis and Osteoclastogenesis in Murine Bone Marrow Cultures (2002)
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Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors (2001)
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Cytokines, bone remodeling, and estrogen deficiency: a 1998 update (1998)
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Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. (1998)
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Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption. (1998)
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INCREASED MARROW ADIPOGENESIS IN THE MURINE MODEL OF DEFECTIVE OSTEOBLASTOGENESIS 109 (1997)
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Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. (1996)
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Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6. (1995)
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Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. (1995)
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Interleukin-11: a new cytokine critical for osteoclast development. (1994)
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