Teresita Bellido
Sourced from institutional research profiles (UAMS TRI or ARA).
Musculoskeletal Health and Disease Research - UAMS Creativity Hub Leadership
Also affiliated: University of Arkansas Medical Center (1998–2023); Central Arkansas Veterans Healthcare System (2000–2026); Richard L. Roudebush VA Medical Center (1993–2024); John L. McClellan Memorial Veterans Hospital (2021–2026); Chongqing Municipal Government (2019); Indiana University Indianapolis (1994–2026); Indiana University School of Medicine (1993–2026); Indiana University – Purdue University Indianapolis (1994–2019); Universidad Nacional del Sur (1987–2009); Indiana University (1994–2016)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Teresita Bellido's research focuses on bone biology, particularly the mechanisms of osteoblast and osteocyte apoptosis and their impact on bone formation and strength. Her work has investigated how various factors, including mechanical stimulation, hormonal signaling, and pharmacological agents, influence bone health. Bellido has studied the role of estrogen and androgen receptors in non-genotropic signaling and the effects of glucocorticoids on bone cells. Her research has also explored the contribution of oxidative stress to skeletal involution, especially in the context of aging and loss of sex steroids.
Bellido has secured significant federal funding for her research endeavors. She has served as PI on six NIH grants, totaling $805,856, including funding for research on glucocorticoid-induced atrophy in bone and muscle, PTH receptor signaling, and the contribution of osteocytes to the musculoskeletal effects of multiple myeloma. She also received NSF funding for a workshop on musculoskeletal biology.
With an h-index of 75 and over 284 publications, Bellido has a substantial scholarly record. Her recent work includes investigations into the reduction of Sost/Sclerostin expression by osteocytes due to mechanical stimulation in vivo and chronic parathyroid hormone elevation in mice. She leads a research group at the University of Arkansas for Medical Sciences and has a notable network of collaborators within the institution.
Metrics
- h-index: 76
- Publications: 264
- Citations: 23,381
Positions
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Chair and Professor 2020–presentUniversity of Arkansas for Medical Sciences Physiology and Cell Biology ORCID
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Musculoskeletal Health and Disease Research - UAMS Creativity Hub Leadership publications 1994–2026University of Arkansas for Medical Sciences Institutional directory
Selected Publications
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Loss of PTH 1 receptor signaling in periodontal cells drives cementum dysfunction and molar ankylosis in mice (2026)
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Region- and Compartment-Specific Elevation of Bone Mass in Mice Following Tsc1 Deletion in 8-kb Dmp1-Cre-Expressing Cells (2026)
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Upregulation of Parathyroid Hormone Receptor 1 (PTH1R) in Non-Mechanostimulated Osteocytes Under High-Glucose Conditions Promotes a Macrophage Pro-Inflammatory and Osteoclastogenic Phenotype via IL-6 Secretion (2026)
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Osteocytes Produces RANKL Via Wnt-TGFβ Signaling Axis for Osteoclastogenesis (2025)
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Caveolin‐1 Regulates Parathyroid Hormone (PTH)‐Related Protein (PTHrP) Actions on PTH Receptor Type 1 in Bone Cells (2025)
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The development of a collagen-nanoscale hydroxyapatite three-dimensional (3D) in vitro culture system for reproducing osteocyte differentiation and tissue mineralization (2025)
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A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma (2024)
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Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective <i>via</i> Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss (2024)
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Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease (2024)
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Sclerostin antibody corrects periodontal disease in type 2 diabetic mice (2024)
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PTH receptor signalling, osteocytes and bone disease induced by diabetes mellitus (2024)
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Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice (2024)
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Proceedings of the 2023 Santa Fe Bone Symposium: Progress and Controversies in the Management of Patients with Skeletal Diseases (2023)
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OR29-04 Vitamin D Signaling Prevents Glucocorticoid-Induced Musculoskeletal Tissue Loss And Cardiac Dysfunction By Targeting The Atrogene Pathway (2023)
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THU346 Repairing Skeletal Deterioration In Diabetes With Bone Anabolic Therapies (2023)
ARA Academy 2018 ARA Scholar
Dr. Bellido is an internationally recognized leader in bone research. She holds major grants from the NIH and Veterans Administration and has served as president of the American Society for Bone and Mineral Research (2020). Her research focuses on signal transduction in bone and muscle, with emphasis on osteocyte biology in health and disease and hormonal action mechanisms in the musculoskeletal system.
Policy Impact
Holds major NIH and VA grants; former president of the American Society for Bone and Mineral Research, bringing national leadership and federal funding to UAMS.
Growth Areas
['Population Health Innovations & Clinical Research']
Federal Grants 7 $805,856 total
BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB)
Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- PPARG regulates osteocyte function during aging NIH/Nat. Inst. on Aging via University of Toledo
- ASBMR Three Year Pre-Meeting Symposia NIH
- CYTOKINE SIGNAL TRANSDUCTION IN OSTEOBLASTIC CELLS NIH
- Cytokine Signal Transduction in Osteoblastic Cells NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
- Osteocyte control of bone formation via Sost NIH
- 2022 Musculoskeletal Biology Workshop National Science Foundation
- Bisphosphonate binding to connexin43-expressing cells NIH
- 2023 Orthopedic Research Society Musculoskeletal Biology Workshop National Science Foundation
- Eighteenth Forum on Osteoporosis and Metabolic Bone Diseases for Fellows in Training NIH
Collaboration Network
Top Collaborators
- Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
- Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
- Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength
- Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis
- Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss
Showing 5 of 24 shared publications
- Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
- Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength
- Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis
- Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines
- Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss
Showing 5 of 23 shared publications
- Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
- Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Transcriptional Activation of the p21 Gene by Interleukin-6 Type Cytokines
Showing 5 of 13 shared publications
- Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines
- Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
- Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts
- Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
- Transient Versus Sustained Phosphorylation and Nuclear Accumulation of ERKs Underlie Anti-Versus Pro-apoptotic Effects of Estrogens
Showing 5 of 12 shared publications
- Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
- Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
- Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength
- Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines
- Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss
Showing 5 of 12 shared publications
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Reversal of the diabetic bone signature with anabolic therapies in mice
- Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice
Showing 5 of 12 shared publications
- Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
- Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength
- Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis
- Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
- Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts
Showing 5 of 11 shared publications
- Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
- Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis via Distinct Molecular Mechanisms Downstream of Extracellular Signal-regulated Kinase Activation
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
Showing 5 of 10 shared publications
- Reversal of the diabetic bone signature with anabolic therapies in mice
- Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response
- Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
- Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice
- Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective <i>via</i> Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss
Showing 5 of 10 shared publications
- The osteocyte as a signaling cell
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Wnt/β-catenin Signaling Controls Maxillofacial Hyperostosis
Showing 5 of 7 shared publications
- Reversal of the diabetic bone signature with anabolic therapies in mice
- PTH receptor signalling, osteocytes and bone disease induced by diabetes mellitus
- Sclerostin antibody corrects periodontal disease in type 2 diabetic mice
- Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice
- Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice
Showing 5 of 7 shared publications
- Reversal of the diabetic bone signature with anabolic therapies in mice
- Sclerostin antibody corrects periodontal disease in type 2 diabetic mice
- Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective <i>via</i> Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss
- Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice
- Loss of PTH 1 receptor signaling in periodontal cells drives cementum dysfunction and molar ankylosis in mice
Showing 5 of 7 shared publications
- Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Nongenotropic, Anti-Apoptotic Signaling of 1α,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes
- Induction of Osteoblast Differentiation by Selective Activation of Kinase-Mediated Actions of the Estrogen Receptor
Showing 5 of 6 shared publications
- Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Nongenotropic, Anti-Apoptotic Signaling of 1α,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes
- Kinase-mediated transcription, activators of nongenotropic estrogen–like signaling (ANGELS), and osteoporosis: A different perspective on the HRT dilemma
Showing 5 of 6 shared publications
- Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
- Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines
- Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss
- Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
- Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs
Showing 5 of 6 shared publications
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